Search Results - "Son, Ilhong"

Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Heo, Jinju, Son, Ilhong

“…α-Synuclein (αSyn) is an important player in Parkinson's disease (PD) pathogenesis. The aggregation of αSyn is mainly formed in the cytoplasm, whereas some…”
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An early endosome regulator, Rab5b, is an LRRK2 kinase substrate by Yun, Hye Jin, Kim, Hyejung, Ga, Inhwa, Oh, Hakjin, Ho, Dong Hwan, Kim, Jiyoung, Seo, Hyemyung, Son, Ilhong, Seol, Wongi

“…Leucine-rich repeat kinase 2 (LRRK2) has been identified as a causative gene for Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, both of…”
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Expression of transduced nucleolin promotes the clearance of accumulated α-synuclein in rodent cells and animal model by Ho, Dong Hwan, Nam, Daleum, Jeong, Soyeon, Seo, Mi Kyoung, Park, Sung Woo, Seol, Wongi, Son, Ilhong

“…Alpha-synuclein (αSyn) is a major component of Lewy bodies, which are a known pathogenic marker of Parkinson's disease (PD). The dysfunction of protein…”
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Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Seo, Mi Kyoung, Park, Sung Woo, Son, Ilhong

“…Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic…”
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LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss by Ho, Dong-Hwan, Nam, Daleum, Seo, Mikyoung, Park, Sung-Woo, Seol, Wongi, Son, Ilhong

“…Evidence suggests that crosstalk occurs between microglial leucine-rich repeat kinase 2 (LRRK2)-a regulator of neuroinflammation-and neuron-released…”
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Therapeutic Effect of Padina arborescens Extract on a Cell System Model for Parkinson's Disease by Ho, Dong Hwan, Kim, Hyejung, Nam, Daleum, Seo, Mi Kyoung, Park, Sung Woo, Kim, Dong-Kyu, Son, Ilhong

“…Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein are involved in the pathogenesis of Parkinson's disease. The activity of LRRK2 in microglial cells is…”
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G2385R and I2020T Mutations Increase LRRK2 GTPase Activity by Seo, Hyemyung, Son, Ilhong, Joe, Eun-hye, Jang, Jihoon, Ho, Dong Hwan, Seol, Wongi

“…The LRRK2 mutation is a major causal mutation in familial Parkinson’s disease. Although LRRK2 contains functional GTPase and kinase domains and their…”
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G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses by Ho, Dong Hwan, Lee, Heajin, Son, Ilhong, Seol, Wongi

“…Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson's disease (PD). LRRK2 has kinase and GTPase activities, and mediates several…”
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Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease by Ho, Dong Hwan, Seo, Hyemyung, Seol, Wongi, Lee, Sung Ik, Jeong, Soyeon, Jang, Jihoon, Son, Ilhong

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease. Oxidative stress is the most critical risk factor for neurodegenerative diseases,…”
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Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis by Kim, Hyejung, Son, Ilhong, Seol, Wongi

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease (PD) in an autosomal dominant manner. Pathogenic mutations of LRRK2 such as…”
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Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson's disease by Nam, Daleum, Kim, Ami, Han, Sun Jung, Lee, Sung-Ik, Park, Sung-Hye, Seol, Wongi, Son, Ilhong, Ho, Dong Hwan

“…Research on Parkinson's disease (PD) has been focused on the development of PD diagnostic tools as much as the development of PD therapeutics. Several genetic…”
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KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis by Kook, Myung Geun, Choi, Soon Won, Seo, Yoojin, Kim, Dong Woung, Song, Bong Keun, Son, Ilhong, Kim, Sungchul, Kang, Kyung-Sun

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main…”
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Mecasin treatment in patients with amyotrophic lateral sclerosis: study protocol for a randomized controlled trial by Kim, Sungha, Kim, Jae Kyoun, Son, Mi Ju, Kim, Dongwoung, Song, Bongkeun, Son, Ilhong, Kang, Hyung Won, Lee, Jongdeok, Kim, Sungchul

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes paralysis of limb, swallowing, and breathing muscles. Riluzole, the Food…”
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Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis by Kim, Hyejung, Son, Ilhong, Seol, Wongi

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease (PD) in an autosomal dominant manner. Pathogenic mutations of LRRK2 such as…”
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Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity by Jang, Jihoon, Oh, Hakjin, Nam, Daleum, Seol, Wongi, Seo, Mi Kyoung, Park, Sung Woo, Kim, Hyung Gun, Seo, Hyemyung, Son, Ilhong, Ho, Dong Hwan

“…Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson's disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis,…”
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26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats by Yang, Muhack, Lee, Seongjin, Wang, Tingting, Cha, Eunhye, Jang, Jongwon, Kim, Dongwoung, Song, Bong-Keun, Son, Ilhong, Kim, Joonyup, Kang, Hyung Won, Kim, Sungchul

“…KCHO-1(Mecasin), also called Gamijakyakgamchobuja-tang originally, is a combination of some traditional herbal medicines in East Asia. This medicine has been…”
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Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression by Ho, Dong Hwan, Kim, Hyejung, Kim, Jisun, Sim, Hyuna, Ahn, Hyunjun, Kim, Janghwan, Seo, Hyemyung, Chung, Kwang Chul, Park, Bum-Joon, Son, Ilhong, Seol, Wongi

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Characterization of Parkinson's disease-related pathogenic TMEM230 mutants by Nam, Daleum, Kim, Hyejung, Choi, Dong-Joo, Bae, Yun-Hee, Lee, Byoung Dae, Son, Ilhong, Seol, Wongi

“…Parkinson's disease (PD) is the second most common neurodegenerative disease. Although most PD cases are sporadic, 5-10% of them are hereditary and several…”
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Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression by Ho, Dong Hwan, Kim, Hyejung, Kim, Jisun, Sim, Hyuna, Ahn, Hyunjun, Kim, Janghwan, Seo, Hyemyung, Chung, Kwang Chul, Park, Bum-Joon, Son, Ilhong, Seol, Wongi

“…Background Leucine-rich repeat kinase 2 (LRRK2) is a gene in which a mutation causes Parkinson's disease (PD), and p53 is a prototype tumor suppressor. In…”
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Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson's disease in an autosomal dominant manner by Park, Ji-Min, Ho, Dong-Hwan, Yun, Hye Jin, Kim, Hye-Jung, Lee, Chan Hong, Park, Sung Woo, Kim, Young Hoon, Son, Ilhong, Seol, Wongi

“…LRRK2 (leucine-rich repeat kinase 2) has been identified as a gene corresponding to PARK8, an autosomal-dominant gene for familial Parkinson's disease (PD)…”
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