Search Results - "Somps, Christopher J."

Performance of biomarkers NF-L, NSE, Tau and GFAP in blood and cerebrospinal fluid in rat for the detection of nervous system injury by Vlasakova, Katerina, Tsuchiya, Takayuki, Garfinkel, Ivy N, Ruth, Michael P, Tyszkiewicz, Cheryl, Detwiler, Theodore J, Somps, Christopher J, Di Cesare Mannelli, Lorenzo, Glaab, Warren E

“…Target organ toxicity is often a reason for attritions in nonclinical and clinical drug development. Leveraging emerging safety biomarkers in nonclinical…”
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Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy by Huehnchen, Petra, Schinke, Christian, Bangemann, Nikola, Dordevic, Adam D, Kern, Johannes, Maierhof, Smilla K, Hew, Lois, Nolte, Luca, Körtvelyessy, Peter, Göpfert, Jens C, Ruprecht, Klemens, Somps, Christopher J, Blohmer, Jens-Uwe, Sehouli, Jalid, Endres, Matthias, Boehmerle, Wolfgang

“…BACKGROUNDPaclitaxel chemotherapy frequently induces dose-limiting sensory axonal polyneuropathy. Given that sensory symptoms are challenging to assess…”
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Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species by Fader, Kelly A., Pardo, Ingrid D., Kovi, Ramesh C., Somps, Christopher J., Wang, Helen Hong, Vaidya, Vishal S., Ramaiah, Shashi K., Sirivelu, Madhu P.

“…Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by…”
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The Role of Hypoxia in 2-Butoxyethanol–Induced Hemangiosarcoma by Laifenfeld, Daphna, Gilchrist, Annalyn, Drubin, David, Jorge, Milena, Eddy, Sean F., Frushour, Brian P., Ladd, Bill, Obert, Leslie A., Gosink, Mark M., Cook, Jon C., Criswell, Kay, Somps, Christopher J., Koza-Taylor, Petra, Elliston, Keith O., Lawton, Michael P.

“…To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach…”
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An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models by Harney, Julie, Bajaj, Piyush, Finley, James E., Kopec, Anna K., Koza-Taylor, Petra H., Boucher, Germaine G., Lanz, Thomas A., Doshna, Colleen M., Somps, Christopher J., Adkins, Karissa, Houle, Christopher

“…Alveolar type II (ATII) epithelial cells contain lamellar bodies (LBs) which synthesize and store lung surfactants. In animals, the inhibition or knockout of…”
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No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss by Walters, Karen M., Boucher, Magalie, Boucher, Germaine G., Opsahl, Alan C., Mouton, Peter R., Liu, Chang-Ning, Ritenour, Casey R., Kawabe, Thomas T., Pryski, Hayley N., Somps, Christopher J.

“…The potential for neurogenesis in the cranial (superior) cervical ganglia (SCG) of the sympathetic nervous system was evaluated. Eleven consecutive daily doses…”
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Ocular Toxicity Assessment From Systemically Administered Xenobiotics: Considerations in Drug Development by Brock, William J., Somps, Christopher J., Torti, Vince, Render, James A., Jamison, Jeffrey, Rivera, Maria I.

“…The eye is a unique sensory structure, which must be evaluated for toxicity to determine the safety of drugs, industrial chemicals, and consumer products…”
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Changes in neurotransmitter uptake in the spinal cord following peripheral nerve injury by Somps, C J, Boyajian, C L, Luttges, M W

“…Changes in neurotransmitter systems of the spinal cord were studied in response to peripheral nerve injury. The uptake and compartmentalization of radiolabeled…”
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