Search Results - "Sompallae, R"

FOXM1 is a therapeutic target for high-risk multiple myeloma by Gu, C, Yang, Y, Sompallae, R, Xu, H, Tompkins, V S, Holman, C, Hose, D, Goldschmidt, H, Tricot, G, Zhan, F, Janz, S

“…The transcription factor forkhead box M1 (FOXM1) is a validated oncoprotein in solid cancers, but its role in malignant plasma cell tumors such as multiple…”
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EGFR and ERBB2 exon 20 insertion/duplication in advanced non-small cell lung cancer: genomic profiling and clinicopathologic features by Sompallae, Ramakrishna R, Dundar, Bilge, Guseva, Natalya V, Bossler, Aaron D, Ma, Deqin

“…Exon 20 (ex20) in-frame insertions or duplications (ins/dup) in epidermal growth factor receptor ( ) and its analog erb-b2 receptor tyrosine kinase 2 ( ) are…”
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The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice by Rosean, T R, Tompkins, V S, Olivier, A K, Sompallae, R, Norian, L A, Morse, H C, Waldschmidt, T J, Janz, S

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Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy by Thomas, C. P., Mansilla, M. A., Sompallae, R., Mason, S. O., Nishimura, C. J., Kimble, M. J., Campbell, C. A., Kwitek, A. E., Darbro, B. W., Stewart, Z. A., Smith, R. J. H.

“…Related living kidney donors (LKDs) are at higher risk of end‐stage renal disease (ESRD) compared with unrelated LKDs. A genetic panel was developed to screen…”
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Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints by Gruhne, B, Sompallae, R, Masucci, M G

“…Epstein–Barr virus (EBV) has been implicated in the pathogenesis of human malignancies, but its contribution to tumorigenesis is not well understood. EBV…”
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18F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib by Duncan, K, Rosean, T R, Tompkins, V S, Olivier, A, Sompallae, R, Zhan, F, Tricot, G, Acevedo, M R, Ponto, L L B, Walsh, S A, Tygrett, L T, Berger, A J, Waldschmidt, T, Morse, H C, Sunderland, J J, Janz, S

“…18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) are useful imaging modalities for evaluating tumor progression and…”
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Transgenic mouse model of IgM+ lymphoproliferative disease mimicking Waldenström macroglobulinemia by Tompkins, V S, Sompallae, R, Rosean, T R, Walsh, S, Acevedo, M, Kovalchuk, A L, Han, S-S, Jing, X, Holman, C, Rehg, J E, Herms, S, Sunderland, J S, Morse, H C, Janz, S

“…Waldenström macroglobulinemia (WM) is a low-grade incurable immunoglobulin M + (IgM + ) lymphoplasmacytic lymphoma for which a genetically engineered mouse…”
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Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria by Vijay, Rahul, Guthmiller, Jenna J., Sturtz, Alexandria J., Surette, Fionna A., Rogers, Kai J., Sompallae, Ramakrishna R., Li, Fengyin, Pope, Rosemary L., Chan, Jo-Anne, de Labastida Rivera, Fabian, Andrew, Dean, Webb, Lachlan, Maury, Wendy J., Xue, Hai-Hui, Engwerda, Christian R., McCarthy, James S., Boyle, Michelle J., Butler, Noah S.

“…Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the development of long-lived and effective humoral immunity against…”
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Targeted broad-based genetic testing by next-generation sequencing informs diagnosis and facilitates management in patients with kidney diseases by Mansilla, M Adela, Sompallae, Ramakrishna R, Nishimura, Carla J, Kwitek, Anne E, Kimble, Mycah J, Freese, Margaret E, Campbell, Colleen A, Smith, Richard J, Thomas, Christie P

“…The clinical diagnosis of genetic renal diseases may be limited by the overlapping spectrum of manifestations between diseases or by the advancement of disease…”
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Validation of Optical Genome Mapping for the Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy by Stence, Aaron A., Thomason, Jon G., Pruessner, Jonathan A., Sompallae, Ramakrishna R., Snow, Anthony N., Ma, Deqin, Moore, Steven A., Bossler, Aaron D.

“…The molecular diagnosis of facioscapulohumeral muscular dystrophy (FSHD) relies on detecting contractions of the unique D4Z4 repeat array at the chromosome…”
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Genomic Profiling of Metastatic Uveal Melanoma Shows Frequent Coexisting BAP1 or SF3B1 and GNAQ/GNA11 Mutations and Correlation With Prognosis by Isaacson, Alexandra L, Sompallae, Ramakrishna R, Guseva, Natalya V, Bellizzi, Andrew M, Bossler, Aaron D, Ma, Deqin

“…Abstract Objectives To identify therapeutic targets and correlate with clinical outcomes from mutation profiling of metastatic uveal melanoma (UM) using…”
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Molecular characterization and survival analysis of a cohort of glioblastoma, IDH-wildtype by Dundar, Bilge, Alsawas, Mouaz, Masaadeh, Amr, Conway, Kyle, Snow, Anthony N., Sompallae, Ramakrishna R., Bossler, Aaron D., Ma, Deqin, Lopes Abath Neto, Osorio

“…Glioblastoma, IDH-wild type, the most common malignant primary central nervous system tumor, represents a formidable challenge in clinical management due to…”
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Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species by Gruhne, Bettina, Sompallae, Ramakrishna, Marescotti, Diego, Kamranvar, Siamak Akbari, Gastaldello, Stefano, Masucci, Maria G

“…The Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis…”
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The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates by Hassink, Gerco C, Zhao, Bin, Sompallae, Ramakrishna, Altun, Mikael, Gastaldello, Stefano, Zinin, Nikolay V, Masucci, Maria G, Lindsten, Kristina

“…Ubiquitination regulates membrane events such as endocytosis, membrane trafficking and endoplasmic‐reticulum‐associated degradation (ERAD). Although the…”
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The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins by Coppotelli, Giuseppe, Mughal, Nouman, Callegari, Simone, Sompallae, Ramakrishna, Caja, Laia, Luijsterburg, Martijn S, Dantuma, Nico P, Moustakas, Aristidis, Masucci, Maria G

“…Viral proteins reprogram their host cells by hijacking regulatory components of protein networks. Here we describe a novel property of the Epstein-Barr virus…”
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Abstract P4-05-14: Molecular and immunohistochemical profile of invasive micropapillary breast carcinoma by Thomas, A, Askeland, RW, Guseva, NV, Sompallae, R, Ma, D

“…Abstract Background: Invasive micropapillary carcinoma (IMPC) of the breast is an uncommon disease subtype that is generally considered aggressive. A variety…”
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The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome by Zhao, Bin, Velasco, Kelly, Sompallae, Ramakrishna, Pfirrmann, Thorsten, Masucci, Maria G., Lindsten, Kristina

“…► USP4 interacts with the proteasome subunit S9/Rpn6 in GST pull-down and co-immunoprecipitation assays. ► Endogenous USP4 associates with the 26S proteasome…”
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EBV and genomic instability—A new look at the role of the virus in the pathogenesis of Burkitt's lymphoma by Gruhne, Bettina, Kamranvar, Siamak Akbari, Masucci, Maria G, Sompallae, Ramakrishna

“…Abstract Epidemiological and molecular evidence links Epstein–Barr virus (EBV) carriage to the pathogenesis of human malignancies of lymphoid and epithelial…”
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Transcription profiling of Epstein-Barr virus nuclear antigen (EBNA)-1 expressing cells suggests targeting of chromatin remodeling complexes by Sompallae, Ramakrishna, Callegari, Simone, Kamranvar, Siamak Akbari, Masucci, Maria G

“…The Epstein-Barr virus (EBV) encoded nuclear antigen (EBNA)-1 regulates virus replication and transcription, and participates in the remodeling of the cellular…”
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Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival by Guerra, Lina, Guidi, Riccardo, Slot, Ilse, Callegari, Simone, Sompallae, Ramakrishna, Pickett, Carol L, Åström, Stefan, Eisele, Frederik, Wolf, Dieter, Sjögren, Camilla, Masucci, Maria G, Frisan, Teresa

“…The DNA damage response triggered by bacterial cytolethal distending toxins (CDTs) is associated with activation of the actin-regulating protein RhoA and…”
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