Search Results - "Sommers, C L"

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules by Rodriguez-Peña, A B, Gomez-Rodriguez, J, Kortum, R L, Palmer, D C, Yu, Z, Guittard, G C, Wohlfert, E A, Silver, P B, Misplon, J A, Sommers, C L, Feigenbaum, L, Epstein, S L, Caspi, R R, Belkaid, Y, Restifo, N P, Samelson, L E, Balagopalan, L

“…Linker for activation of T cells (LAT) is critical for the propagation of T-cell signals upon T-cell receptor (TCR) activation. Previous studies demonstrated…”
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Fine Tuning of TCR Signaling by CD5 by Azzam, Hala S, DeJarnette, Jan B, Huang, Kun, Emmons, Rebecca, Park, Cheung-Seog, Sommers, Connie L, El-Khoury, Dalal, Shores, Elizabeth W, Love, Paul E

“…Current data indicate that CD5 functions as an inhibitor of TCR signal transduction. Consistent with this role, thymocyte selection in TCR transgenic/CD5(-/-)…”
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The LAT story: a tale of cooperativity, coordination, and choreography by Balagopalan, Lakshmi, Coussens, Nathan P, Sherman, Eilon, Samelson, Lawrence E, Sommers, Connie L

“…The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive…”
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Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development by Sommers, C L, Menon, R K, Grinberg, A, Zhang, W, Samelson, L E, Love, P E

“…The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction…”
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Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines by Thompson, E W, Paik, S, Brünner, N, Sommers, C L, Zugmaier, G, Clarke, R, Shima, T B, Torri, J, Donahue, S, Lippman, M E

“…Lack of estrogen receptor (ER) and presence of vimentin (VIM) associate with poor prognosis in human breast cancer. We have explored the relationships between…”
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Alterations in β-catenin phosphorylation and plakoglobin expression in human breast cancer cells by SOMMERS, C. L, GELMANN, E. P, KEMLER, R, COWIN, P, BYERS, S. W

“…Because the cell adhesion molecule epithelial cadherin (E-cadherin) is absent in many invasive carcinomas, we transfected the E-cadherin gene into…”
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Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines by SOMMERS, C. L, HECKFORD, S. E, SKERKER, J. M, WORLAND, P, TORRI, J. A, THOMPSON, E. W, BYERS, S. W, GELMANN, E. P

“…We have previously observed that breast cancer cell lines could exhibit either epithelial or fibroblastic phenotypes as reflected by their morphologies and…”
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Differential expression of extracellular matrix components in rat Sertoli cells by DAVIS, C. M, PAPADOPOULOS, V, SOMMERS, C. L, KLEINMAN, H. K, DYM, M

“…We studied expression of laminin, fibronectin, and Type IV collagen in the testis by means of immunofluorescence and immunoblot analysis and also examined gene…”
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Essential Role of LAT in T Cell Development by Zhang, Weiguo, Sommers, Connie L, Burshtyn, Deborah N, Stebbins, Christopher C, DeJarnette, Jan B, Trible, Ronald P, Grinberg, Alexander, Tsay, Henry C, Jacobs, Helena M, Kessler, Craig M, Long, Eric O, Love, Paul E, Samelson, Lawrence E

“…The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules…”
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Invasive and metastatic properties of MCF-7 cells and rasH-transfected MCF-7 cell lines by Gelmann, E P, Thompson, E W, Sommers, C L

“…In vitro invasion and in vivo metastasis assays were performed with a panel of MCF-7 cells transfected with isogenic constructs of mutated rasH genes. Both…”
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RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation by Rajagopal, K, Sommers, C L, Decker, D C, Mitchell, E O, Korthauer, U, Sperling, A I, Kozak, C A, Love, P E, Bluestone, J A

“…A novel T cell-specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma…”
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Specific Requirement for CD3ε in T Cell Development by DeJarnette, Jan B., Sommers, Connie L., Huang, Kun, Woodside, Kenneth J., Emmons, Rebecca, Katz, Kenneth, Shores, Elizabeth W., Love, Paul E.

“…T cell antigen receptor (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in association with dimers of signal transducing invariant subunits…”
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Differentiation state and invasiveness of human breast cancer cell lines by Sommers, C L, Byers, S W, Thompson, E W, Torri, J A, Gelmann, E P

“…Eighteen breast cancer cell lines were examined for expression of markers of epithelial and fibroblastic differentiation: E-cadherin, desmoplakins, ZO-1,…”
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Function of CD3 epsilon-mediated signals in T cell development by Sommers, C L, Dejarnette, J B, Huang, K, Lee, J, El-Khoury, D, Shores, E W, Love, P E

“…The T cell antigen receptor (TCR) and pre-TCR complexes are composed of multiple signal-transducing subunits (CD3 gamma, CD3 delta, CD3 epsilon, and zeta) that…”
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The role of cadherin-mediated adhesion in breast cancer by Sommers, C L

“…The cell adhesion molecule E-cadherin is expressed on the basolateral surfaces of normal mammary epithelial cells and is lost in a subset of breast cancers…”
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The effect of pH on the in vitro colony forming ability of transitional cell carcinoma cells treated with various chemotherapeutic agents: implications for in vivo therapy by Tarkington, M, Sommers, C L, Gelmann, E P, Tefft, M C, Lynch, J H

“…Extracellular pH may affect the sensitivity of cancer cells to chemotherapy agents. In an attempt to maximize the conditions for chemotherapy treatment of…”
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Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire by Shores, E W, Tran, T, Grinberg, A, Sommers, C L, Shen, H, Love, P E

“…Immature thymocytes undergo a selection process within the thymus based on their T cell antigen receptor (TCR) specificity that results either in their…”
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A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection by Sommers, C L, Rabin, R L, Grinberg, A, Tsay, H C, Farber, J, Love, P E

“…Recent data indicate that several members of the Tec family of protein tyrosine kinases function in antigen receptor signal transduction. Txk, a Tec family…”
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T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma) by Shores, E W, Ono, M, Kawabe, T, Sommers, C L, Tran, T, Lui, K, Udey, M C, Ravetch, J, Love, P E

“…The zeta family includes zeta, eta, and FcepsilonRIgamma (Fcgamma). Dimers of the zeta family proteins function as signal transducing subunits of the T cell…”
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Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength by Byers, S W, Sommers, C L, Hoxter, B, Mercurio, A M, Tozeren, A

“…Defects in the expression or function of the calcium dependent cell-cell adhesion molecule E-cadherin are common in invasive, metastatic carcinomas. In the…”
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