Search Results - "Sommerfeld, Annika"

Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α5β1 integrin towards choleresis by Bonus, Michele, Sommerfeld, Annika, Qvartskhava, Natalia, Görg, Boris, Ludwig, Beatrice Stefanie, Kessler, Horst, Gohlke, Holger, Häussinger, Dieter

“…Functional selectivity is the ligand-specific activation of certain signal transduction pathways at a receptor and has been described for G protein-coupled…”
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Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate by Mayer, Patrick G K, Qvartskhava, Natalia, Sommerfeld, Annika, Görg, Boris, Häussinger, Dieter

“…Hydrophobic bile salts, such as glycochenodeoxycholate (GCDC) can trigger hepatocyte apoptosis, which is prevented by tauroursodesoxycholate (TUDC), but the…”
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CD95 Ligand Is a Proliferative and Antiapoptotic Signal in Quiescent Hepatic Stellate Cells by Reinehr, Roland, Sommerfeld, Annika, Häussinger, Dieter

“…Background & Aims: Despite expression of CD95 (Fas) receptor, hepatic stellate cells (HSCs) are fairly resistant toward CD95 ligand (CD95L)-induced cell death…”
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Bile Acid-induced Epidermal Growth Factor Receptor Activation in Quiescent Rat Hepatic Stellate Cells Can Trigger Both Proliferation and Apoptosis by Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

“…Bile acids have been reported to induce epidermal growth factor receptor (EGFR) activation and subsequent proliferation of activated hepatic stellate cells…”
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Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms by Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

“…Background/Aims: Ursodeoxycholic acid, which in vivo is rapidly converted into its taurine conjugate, is frequently used for the treatment of cholestatic liver…”
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Investigating cell-ECM contact changes in response to hypoosmotic stimulation of hepatocytes in vivo with DW-RICM by Mundinger, Tabea A, Sommerfeld, Annika, Reinehr, Roland, Spatz, Joachim P, Häussinger, Dieter, Boehm, Heike

“…Hepatocyte volume regulation has been shown to play an important role in cellular metabolism, proliferation, viability and especially in hepatic functions such…”
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The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver by Reinehr Roland, Sommerfeld Annika, Häussinger Dieter

“…The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and…”
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Amplification of CD95 Activation by Caspase 8-induced Endosomal Acidification in Rat Hepatocytes by Reinehr, Roland, Sommerfeld, Annika, Keitel, Verena, Grether-Beck, Susanne, Häussinger, Dieter

“…Although in rat hepatocytes CD95 is predominantly located inside the cell with almost undetectable immunostaining at the plasma membrane, the addition of…”
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Correction: Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis by Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

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TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro by Reich, Maria, Deutschmann, Kathleen, Sommerfeld, Annika, Klindt, Caroline, Kluge, Stefanie, Kubitz, Ralf, Ullmer, Christoph, Knoefel, Wolfram T, Herebian, Diran, Mayatepek, Ertan, Häussinger, Dieter, Keitel, Verena

“…Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes…”
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Free Fatty Acids Shift Insulin-induced Hepatocyte Proliferation towards CD95-dependent Apoptosis by Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

“…Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and…”
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Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver by Santosa, David, Castoldi, Mirco, Paluschinski, Martha, Sommerfeld, Annika, Häussinger, Dieter

“…microRNAs are an abundant class of small non-coding RNAs that negatively regulate gene expression. Importantly, microRNA activity has been linked to the…”
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Insulin Induces Swelling-dependent Activation of the Epidermal Growth Factor Receptor in Rat Liver by Reinehr, Roland, Sommerfeld, Annika, Häussinger, Dieter

“…The aim of the study was to analyze whether the proliferative effects of insulin in rat liver involve cross-signaling toward the epidermal growth factor…”
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α5β1‐integrins are sensors for tauroursodeoxycholic acid in hepatocytes by Gohlke, Holger, Schmitz, Birte, Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

“…Ursodeoxycholic acid, which in vivo is converted to its taurine conjugate tauroursodeoxycholic acid (TUDC), is a mainstay for the treatment of cholestatic…”
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Regulation of Plasma Membrane Localization of the Na+-Taurocholate Cotransporting Polypeptide (Ntcp) by Hyperosmolarity and Tauroursodeoxycholate by Sommerfeld, Annika, Mayer, Patrick G.K., Cantore, Miriam, Häussinger, Dieter

“…In perfused rat liver, hepatocyte shrinkage induces a Fyn-dependent retrieval of the bile salt export pump (Bsep) and multidrug resistance-associated protein 2…”
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The Src Family Kinase Fyn Mediates Hyperosmolarity-induced Mrp2 and Bsep Retrieval from Canalicular Membrane by Cantore, Miriam, Reinehr, Roland, Sommerfeld, Annika, Becker, Martin, Häussinger, Dieter

“…In perfused rat liver, hyperosmolarity induces Mrp2- (Kubitz, R., D'urso, D., Keppler, D., and Häussinger, D. (1997) Gastroenterology 113, 1438–1442) and Bsep…”
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Regulation of plasma membrane localization of the Na+-taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate by Sommerfeld, Annika, Mayer, Patrick G.K., Cantore, Miriam, Häussinger, Dieter

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Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR) by Garbers, Christoph, Kuck, Fabian, Aparicio-Siegmund, Samadhi, Konzak, Kirstin, Kessenbrock, Mareike, Sommerfeld, Annika, Häussinger, Dieter, Lang, Philipp, Brenner, Dirk, Mak, Tak Wah, Rose-John, Stefan, Essmann, Frank, Schulze-Osthoff, Klaus, Piekorz, Roland, Scheller, Jürgen

“…Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the…”
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[alpha]5[beta]1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes by Gohlke, Holger, Schmitz, Birte, Sommerfeld, Annika, Reinehr, Roland, Häussinger, Dieter

“…Ursodeoxycholic acid, which in vivo is converted to its taurine conjugate tauroursodeoxycholic acid (TUDC), is a mainstay for the treatment of cholestatic…”
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Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α 5 β 1 integrin towards choleresis by Bonus, Michele, Sommerfeld, Annika, Qvartskhava, Natalia, Görg, Boris, Ludwig, Beatrice Stefanie, Kessler, Horst, Gohlke, Holger, Häussinger, Dieter

“…Functional selectivity is the ligand-specific activation of certain signal transduction pathways at a receptor and has been described for G protein-coupled…”
Get full text