Search Results - "Sommer, Pascal"

FBN2 Silencing Recapitulates Hypoxic Conditions and Induces Elastic Fiber Impairment in Human Dermal Fibroblasts by Boizot, Jérémy, Minville-Walz, Mélaine, Reinhardt, Dieter Peter, Bouschbacher, Marielle, Sommer, Pascal, Sigaudo-Roussel, Dominique, Debret, Romain

“…Most chronic wounds are characterized by varying degrees of hypoxia and low partial pressures of O that may favor the development of the wound and/or delay…”
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In vitro epidermis model mimicking IGF‐1–specific age‐related decline by Mainzer, Carine, Remoué, Noëlle, Molinari, Jennifer, Rousselle, Patricia, Barricchello, Carla, Lago, Juliana C., Sommer, Pascal, Sigaudo‐Roussel, Dominique, Debret, Romain

“…Ageing is a complex multifaceted process affecting skin functionality and structure. Several 3D organotypic skin culture models have reproduced ageing by…”
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Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 by Fhayli, Wassim, Boëté, Quentin, Kihal, Nadjib, Cenizo, Valérie, Sommer, Pascal, Boyle, Walter A, Jacob, Marie-Paule, Faury, Gilles

“…Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells…”
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The Pro-regions of Lysyl Oxidase and Lysyl Oxidase-like 1 Are Required for Deposition onto Elastic Fibers by Thomassin, Laetitia, Werneck, Claudio C., Broekelmann, Thomas J., Gleyzal, Claudine, Hornstra, Ian K., Mecham, Robert P., Sommer, Pascal

“…These studies were undertaken to determine how lysyl oxidase (LOX) and lysyl oxidase like-1 (LOXL) enzymes are targeted to their substrates in the…”
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Biosynthetic support based on dendritic poly(L-lysine) improves human skin fibroblasts attachment by Lorion, Chloé, Faye, Clément, Maret, Barbara, Trimaille, Thomas, Régnier, Thomas, Sommer, Pascal, Debret, Romain

“…Poly(L-lysine) (PLL) dendrigrafts (DGLs) are arborescent biosynthetic polymers of regular and controlled structures. They have specific properties such as…”
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The Propeptide Domain of Lysyl Oxidase Induces Phenotypic Reversion of Ras-transformed Cells by Palamakumbura, Amitha H., Jeay, Sébastien, Guo, Ying, Pischon, Nicole, Sommer, Pascal, Sonenshein, Gail E., Trackman, Philip C.

“…Lysyl oxidase is an extracellular enzyme critical for the normal biosynthesis of collagens and elastin. In addition, lysyl oxidase reverts ras-mediated…”
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Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta by Behmoaras, Jacques, Slove, Séverin, Seve, Sophie, Vranckx, Roger, Sommer, Pascal, Jacob, Marie-Paule

“…The extracellular matrix (ECM) plays an important role in vascular tissue structure, maintenance, and function. Lysyl oxidases catalyze a key step in the…”
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LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression by Cenizo, Valérie, André, Valérie, Reymermier, Corinne, Sommer, Pascal, Damour, Odile, Perrier, Eric

“…:  The lysyl oxidases lysyl oxidase (LOX) and lysyl oxidase‐like (LOXL) are responsible for elastin cross‐linking. It was shown recently that LOXL is essential…”
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The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model by BOUEZ, Charbel, REYNAUD, Caroline, NOBLESSE, Emmanuelle, THEPOT, Amélie, GLEYZAL, Claudine, KANITAKIS, Jean, PERRIER, Eric, DAMOUR, Odile, SOMMER, Pascal

“…Lysyl oxidase initiates the enzymatic stage of collagen and elastin cross-linking. Among five isoforms comprising the lysyl oxidase family, LOX is the better…”
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Lysyl Oxidase silencing impairs keratinocyte differentiation in a reconstructed-epidermis model by Le Provost, Gabrielle S., Debret, Romain, Cenizo, Valérie, Aimond, Géraldine, Pez, Floriane, Kaniewski, Bastien, André, Valérie, Sommer, Pascal

“…Please cite this paper as: Lysyl Oxidase silencing impairs keratinocyte differentiation in a reconstructed‐epidermis model. Experimental Dermatology 2010; 19:…”
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Down-regulation of Lysyl Oxidase-induced Tumorigenic Transformation in NRK-49F Cells Characterized by Constitutive Activation of Ras Proto-oncogene by Giampuzzi, M, Botti, G, Cilli, M, Gusmano, R, Borel, A, Sommer, P, Di Donato, A

“…Several investigations have suggested a putative tumor suppressor role for lysyl oxidase because it is down-regulated in many human and oncogene-induced…”
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Autocrine Growth Factor Regulation of Lysyl Oxidase Expression in Transformed Fibroblasts by Palamakumbura, Amitha H., Sommer, Pascal, Trackman, Philip C.

“…Lysyl oxidase catalyzes oxidative deamination of peptidyl-lysine and hydroxylysine residues in collagens and lysine residues in elastin to form peptidyl…”
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Path creation, global production networks and regional development: A comparative international analysis of the offshore wind sector by MacKinnon, Danny, Dawley, Stuart, Steen, Markus, Menzel, Max-Peter, Karlsen, Asbjørn, Sommer, Pascal, Hansen, Gard Hopsdal, Normann, Håkon Endresen

“…•Paper highlights the role of wider extra-regional factors in regional path creation.•Develops an analytical framework based on the interplay between four…”
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Expression analysis of recombinant lysyl oxidase (LOX) in myofibroblastlike cells by Seve, Sophie, Decitre, Marie, Gleyzal, Claudine, Farjanel, Jean, Sergeant, Alain, Ricard-Blum, Sylvie, Sommer, Pascal

“…Lysyl oxidase (LOX), originally known as the enzyme required for initiation of covalent cross-linking in collagens and elastin, is now known to be a member of…”
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Effect of ageing on tactile transduction processes by Decorps, Johanna, Saumet, Jean Louis, Sommer, Pascal, Sigaudo-Roussel, Dominique, Fromy, Berengere

“…Graphical abstract…”
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Lysyl Oxidase-like Protein from Bovine Aorta by Borel, Agnes, Eichenberger, Denise, Farjanel, Jean, Kessler, Efrat, Gleyzal, Claudine, Hulmes, David J.S., Sommer, Pascal, Font, Bernard

“…Recently several cDNAs have been described encoding lysyl oxidase-like proteins. Their deduced amino acid sequences are characterized by a strong similarity in…”
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The HIF-1―Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth by PEZ, Floriane, DAYAN, Frédéric, REYNAUD, Caroline, DURIVAULT, Jérome, KANIEWSKI, Bastien, AIMOND, Géraldine, LE PROVOST, Gabrielle S, DEUX, Blandine, CLEZARDIN, Philippe, SOMMER, Pascal, POUYSSEGU, Jacques

“…Adaptation to hypoxia is a driving force for tumor progression that leads to therapy resistance and poor clinical outcome. Hypoxic responses are mainly…”
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Genotype-Correlated Expression of Lysyl Oxidase-Like 1 in Ocular Tissues of Patients with Pseudoexfoliation Syndrome/Glaucoma and Normal Patients by Schlötzer-Schrehardt, Ursula, Pasutto, Francesca, Sommer, Pascal, Hornstra, Ian, Kruse, Friedrich E, Naumann, Gottfried O.H, Reis, André, Zenkel, Matthias

“…Pseudoexfoliation (PEX) syndrome is a generalized disease of the extracellular matrix and the most common identifiable cause of open-angle glaucoma. Two single…”
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Methylation of LOXL1 Promoter by DNMT3A in Aged Human Skin Fibroblasts by Moulin, Léa, Cenizo, Valérie, Antu, Alengo Nyamay, André, Valérie, Pain, Sabine, Sommer, Pascal, Debret, Romain

“…Lysyl oxidase-like 1 (LOXL1) is an amino-oxidase involved in maturation of elastic fibers. Its downregulation has been associated with elastic fibers repair…”
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Development of a Field Mapper for the Determination of the Multipole Components of the Curved HESR Dipole Magnets by Hetzel, Jan Henry, Boker, Jurgen, Bechstedt, Ulf, Quilitzsch, Steffen, Engin, Ilhan, Ehrlich, Christian, Bationo, Bryan, Tripathi, Parth, Soltner, Helmut, Keller, Philip, Sommer, Pascal

“…The high-energy storage ring (HESR) will comprise various normal-conducting magnets, in particular 44 dipole magnets each with a length of 4.2 m and a…”
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