Search Results - "Somjing, Roongjang"

Synthesis and conformation of a novel bridged nucleic acid having a trans-fused 3,5,8-trioxabicyclo[5.3.0]decane structure by Obika, Satoshi, Osaki, Tomohisa, Sekiguchi, Mitsuaki, Somjing, Roongjang, Harada, Yasuki, Imanishi, Takeshi

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Synthesis of Novel 2′-Deoxy Type Trans-3′,4′-Bridged Nucleic Acid by Osaki, Tomohisa, Obika, Satoshi, Harada, Yasuki, Mitsuoka, Yasunori, Sugaya, Kensaku, Sekiguchi, Mitsuaki, Roongjang, Somjing, Imanishi, Takeshi

“…We newly designed and synthesized a 2 ′-deoxy type trans-3′,4′-bridged nucleic acid (trans-3′,4′-BNA) analogues bearing a 4,7-dioxabicyclo[4.3.0]nonane…”
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Pharmacokinetics and pharmacodynamics of meropenem in children with severe infection by Kongthavonsakul, Kritsana, Lucksiri, Aroonrut, Eakanunkul, Suntara, Roongjang, Somjing, Issaranggoon na Ayuthaya, Satja, Oberdorfer, Peninnah

“…Highlights • Meropenem given as intravenous bolus doses of 20 mg/kg/dose every 8 h appeared to be inadequate for the PK/PD target for organisms with an MIC of…”
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Antisense activity of 2′,4′-BNA targeted to bcl-xL gene in HepG2 cell by Roongjang, Somjing, Takahashi, Kurena, Park, Myunji, Obika, Satoshi, Imanishi, Takeshi

“…Introduction of the 2′,4′-BNA monomer into oligonucleotides significantly enhanced binding affinity toward ssRNA and resistance to nuclease degradation. Here,…”
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Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy- trans-3′,4′-bridged nucleic acids by Osaki, Tomohisa, Obika, Satoshi, Harada, Yasuki, Mitsuoka, Yasunori, Sugaya, Kensaku, Sekiguchi, Mitsuaki, Roongjang, Somjing, Imanishi, Takeshi

“…Two novel trans-3′,4′-bridged nucleic acid ( trans-3′,4′-BNA) monomers, one with a 3,5,8-trioxabicyclo[5.3.0]decane structure and the other with a…”
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Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands by Obika, Satoshi, Sekiguchi, Mitsuaki, Somjing, Roongjang, Imanishi, Takeshi

“…Bridge to the right angle: A methylene bridge between the C3′ and N5′ atoms restricts the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate within…”
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Synthesis and Properties of Trans-3‘,4‘-Bridged Nucleic Acids Having Typical S-type Sugar Conformation by Sekiguchi, Mitsuaki, Obika, Satoshi, Harada, Yasuki, Osaki, Tomohisa, Somjing, Roongjang, Mitsuoka, Yasunori, Shibata, Nao, Masaki, Miyuki, Imanishi, Takeshi

“…The synthesis of nucleoside analogues with a conformationally restricted sugar moiety is of great interest. The present research describes the synthesis of BNA…”
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Inhibition of bcl-xL expression by antisense oligonucleotides containing various bridged nucleic acids (BNAs) by Roongjang, Somjing, Takahashi, Kurena, Obika, Satoshi, Imanishi, Takeshi

“…Recently, we described the antisense activity of 2',4'-BNA oligonucleotides in living cells.(1) Here, we examine the antisense effect of 2',4'-BNA, 2',4'-(COC)…”
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SYNTHESIS AND PROPERTIES OF A NOVEL BRIDGED NUCLEIC ACID ANALOGUE, 5′-AMINO-3′,5′-BNA by Sekiguchi, Mitsuaki, Obika, Satoshi, Somjing, Roongjang, Imanishi, Takeshi

“…An oligonucleotide P3′⇉N5′ phosphoramidate (5′-amino-DNA) attracts much attention because of its potential for application to DNA sequencing; however, its…”
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Antisense activity of 2',4'-BNA targeted to bcl-xL gene in HepG2 cell by Roongjang, Somjing, Takahashi, Kurena, Park, Myunji, Obika, Satoshi, Imanishi, Takeshi

“…Introduction of the 2',4'-BNA monomer into oligonucleotides significantly enhanced binding affinity toward ssRNA and resistance to nuclease degradation. Here,…”
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Inhibition of bcl-xLexpression by antisense oligonucleotides containing various bridged nucleic acids (BNAs) by Roongjang, Somjing, Takahashi, Kurena, Obika, Satoshi, Imanishi, Takeshi

“…Recently, we described the antisense activity of 2’,4’-BNA oligonucleotides in living cells.1 Here, we examine the antisense effect of 2’,4’-BNA, 2’,4’-COC and…”
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Adjustment of the γ Dihedral Angle of an Oligonucleotide P3′→N5′ Phosphoramidate Enhances Its Binding Affinity towards Complementary Strands by Obika, Satoshi, Sekiguchi, Mitsuaki, Somjing, Roongjang, Imanishi, Takeshi

“…Brückenschlag zum richtigen Winkel: Eine Methylenbrücke zwischen C3′ und N5′ legt den Diederwinkel γ in einem Oligonucleotid‐P3′→N5′‐phosphoramidat auf die…”
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