Search Results - "Somers, W S"

Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1 by Somers, W S, Tang, J, Shaw, G D, Camphausen, R T

“…P-, E- and L-selectin constitute a family of cell adhesion receptors that mediate the initial tethering and rolling of leukocytes on inflamed endothelium as a…”
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Crystal Structure of the Wild-type von Willebrand Factor A1-Glycoprotein Ibα Complex Reveals Conformation Differences with a Complex Bearing von Willebrand Disease Mutations by Dumas, John J., Kumar, Ravindra, McDonagh, Thomas, Sullivan, Francis, Stahl, Mark L., Somers, William S., Mosyak, Lidia

“…The adhesion of platelets to the subendothelium of blood vessels at sites of vascular injury under high shear conditions is mediated by a direct interaction…”
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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses by Somers, William S, Stamper, Carin C, Zhang, Yan, Tobin, James F, Erbe, David V, Ikemizu, Shinji, Davis, Simon J, Stahl, Mark L, Seehra, Jasbir, Mosyak, Lidia

“…Optimal immune responses require both an antigen-specific and a co-stimulatory signal. The shared ligands B7-1 and B7-2 on antigen-presenting cells deliver the…”
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The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography by Mosyak, Lidia, Zhang, Yan, Glasfeld, Elizabeth, Haney, Steve, Stahl, Mark, Seehra, Jasbir, Somers, William S.

“…In Escherichia coli, FtsZ, a homologue of eukaryotic tubulins, and ZipA, a membrane‐anchored protein that binds to FtsZ, are two essential components of the…”
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Crystal structure of the met repressor-operator complex at 2.8 angstrom resolution reveals DNA recognition by beta -strands by Somers, W S, Phillips, SEV

“…The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair…”
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Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites by Parris, Kevin D, Lin, Laura, Tam, Amy, Mathew, Rebecca, Hixon, Jeffrey, Stahl, Mark, Fritz, Christian C, Seehra, Jasbir, Somers, William S

“…Background: Holo-(acyl carrier protein) synthase (AcpS), a member of the phosphopantetheinyl transferase superfamily, plays a crucial role in the functional…”
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Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin‐12 by Yoon, Christina, Johnston, Steven C., Tang, Jin, Stahl, Mark, Tobin, James F., Somers, William S.

“…Human interleukin‐12 (IL‐12, p70) is an early pro‐inflammatory cytokine, comprising two disulfide‐linked subunits, p35 and p40. We solved the crystal…”
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Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose by Somoza, John R, Menon, Saurabh, Schmidt, Holly, Joseph-McCarthy, Diane, Dessen, Andréa, Stahl, Mark L, Somers, William S, Sullivan, Francis X

“…Background: GDP-mannose 4,6 dehydratase (GMD) catalyzes the conversion of GDP-(d)-mannose to GDP-4-keto, 6-deoxy-( d)-mannose. This is the first and regulatory…”
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Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase by Olland, Andrea M, Underwood, Kathryn W, Czerwinski, Robert M, Lo, Mei-Chu, Aulabaugh, Ann, Bard, Joel, Stahl, Mark L, Somers, William S, Sullivan, Francis X, Chopra, Rajiv

“…The nadD gene, encoding the enzyme nicotinic acid mononucleotide (NaMN) adenylyltransferase (AT), is essential for the synthesis of NAD and subsequent…”
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GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site by Somers, William S, Stahl, Mark L, Sullivan, Francis X

“…Background: In all species examined, GDP-fucose is synthesized from GDP-mannose in a three-step reaction catalyzed by two enzymes, GDP-mannose 4,6 dehydratase…”
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Crystal structure of the met repressor-operator complex at 2.8 Å resolution reveals DNA recognition by β-strands by SOMERS, W. S, PHILLIPS, S. E. V

“…The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair…”
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Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism by Dessen, A, Tang, J, Schmidt, H, Stahl, M, Clark, J D, Seehra, J, Somers, W S

“…Cytosolic phospholipase A2 initiates the biosynthesis of prostaglandins, leukotrienes, and platelet-activating factor (PAF), mediators of the pathophysiology…”
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Cooperative tandem binding of met repressor of Escherichia coli by Phillips, Simon E. V, Manfield, Iain, Parsons, Isobel, Davidson, Barrie E, Rafferty, John B, Somers, William S, Margarita, Danielle, Cohen, Georges N, Saint-Girons, Isabelle, Stockley, Peter G

“…We present biochemical and genetic data to support the hypothesis that the Escherichia coli met repressor, MetJ, binds to synthetic and natural operator…”
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The Met repressor-operator complex: DNA recognition by beta-strands by Somers, W S, Rafferty, J B, Phillips, K, Strathdee, S, He, Y Y, McNally, T, Manfield, I, Navratil, O, Old, I G, Saint-Girons, I

“…The crystal structure of the E. coli met repressor in complex with a synthetic 19-base pair oligonucleotide reveals two dimeric repressor molecules bound to…”
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Crystallization of and preliminary X-ray data for the mouse major urinary protein and rat alpha-2u globulin by Böcskei, Z, Findlay, J B, North, A C, Phillips, S E, Somers, W S, Wright, C E, Lionetti, C, Tirindelli, R, Cavaggioni, A

“…Crystals of the mouse major urinary protein (MUP) and rat alpha-2u globulin (AMG) have been grown from solutions of polyethylene glycol 3350 and CdCl2,…”
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Understanding the Selectivity of Genistein for Human Estrogen Receptor-β Using X-Ray Crystallography and Computational Methods by Manas, Eric S., Xu, Zhang B., Unwalla, Rayomand J., Somers, William S.

“…We present X-ray crystallographic and molecular modeling studies of estrogen receptors-α and -β complexed with the estrogen receptor-β-selective phytoestrogen…”
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Crystal Structure of the GpIbα-Thrombin Complex Essential for Platelet Aggregation by Dumas, John J., Kumar, Ravindra, Seehra, Jasbir, Somers, William S., Mosyak, Lidia

“…Direct interaction between platelet receptor glycoprotein Ibα (GpIbα) and thrombin is required for platelet aggregation and activation at sites of vascular…”
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Structure-Based Design of Estrogen Receptor-β Selective Ligands by Manas, Eric S, Unwalla, Rayomand J, Xu, Zhang B, Malamas, Michael S, Miller, Chris P, Harris, Heather A, Hsiao, Chulai, Akopian, Tatos, Hum, Wah-Tung, Malakian, Karl, Wolfrom, Scott, Bapat, Ashok, Bhat, Ramesh A, Stahl, Mark L, Somers, William S, Alvarez, Juan C

“…We present the structure-based optimization of a series of estrogen receptor-β (ERβ) selective ligands. X-ray cocrystal structures of these ligands complexed…”
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Crystal structure of human cytosolic phospholipase A[d2] reveals a novel topology and catalytic mechanism by Dessen, Andrea, Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.

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Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ) by Xu, Zhang-Bao, Chaudhary, Divya, Olland, Stephane, Wolfrom, Scott, Czerwinski, Robert, Malakian, Karl, Lin, Laura, Stahl, Mark L., Joseph-McCarthy, Diane, Benander, Christina, Fitz, Lori, Greco, Rita, Somers, William S., Mosyak, Lidia

“…A member of the novel protein kinase C (PKC) subfamily, PKCθ, is an essential component of the T cell synapse and is required for optimal T cell activation and…”
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