Search Results - "Somers, Gregory W"

Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis by Chia, William, Somers, W. Gregory, Wang, Hongyan

“…Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors,…”
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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon by Wang, Hongyan, Ouyang, Yingshi, Somers, W Gregory, Chia, William, Lu, Bingwei

“…Self-renewal and differentiation are cardinal features of stem cells. Asymmetric cell division provides one fundamental mechanism by which stem cell…”
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Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts by Wang, Hongyan, Somers, Gregory W, Bashirullah, Arash, Heberlein, Ulrike, Yu, Fengwei, Chia, William

“…The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic…”
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dRTEL1 is essential for the maintenance of Drosophila male germline stem cells by Yang, Ying, Kong, Ruiyan, Goh, Feng Guang, Somers, W Gregory, Hime, Gary R, Li, Zhouhua, Cai, Yu

“…Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in…”
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Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts by Zhang, Fan, Huang, Zhen-Xing, Bao, Hongcun, Cong, Fei, Wang, Huashan, Chai, Phing Chian, Xi, Yongmei, Ge, Wanzhong, Somers, W Gregory, Yang, Ying, Cai, Yu, Yang, Xiaohang

“…The mechanism for the basal targeting of the Miranda (Mira) complex during the asymmetric division of Drosophila neuroblasts (NBs) is yet to be fully…”
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Micro-RNA mediated regulation of proliferation, self-renewal and differentiation of mammalian stem cells by Hime, Gary R., Somers, W. Gregory

“…Metazoan growth and development is maintained by populations of undifferentiated cells, commonly known as stem cells. Stem cells possess several characteristic…”
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A RhoGEF and Rho Family GTPase-Activating Protein Complex Links the Contractile Ring to Cortical Microtubules at the Onset of Cytokinesis by Somers, W.Gregory, Saint, Robert

“…The mechanism that positions the cytokinetic contractile ring is unknown, but derives from the spindle midzone. We show that an interaction between the Rho GTP…”
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Mechanisms of asymmetric progenitor divisions in the Drosophila central nervous system by Sousa-Nunes, Rita, Somers, W Gregory

“…The Drosophila central nervous system develops from polarised asymmetric divisions of precursor cells, called neuroblasts. Decades of research on neuroblasts…”
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Animal cell division: a fellowship of the double ring? by Saint, Robert, Somers, W Gregory

“…Despite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has…”
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Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis by La Marca, John E, Diepstraten, Sarah T, Hodge, Amy L, Wang, Hongyan, Hart, Adam H, Richardson, Helena E, Somers, W Gregory

“…One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the testis, have been…”
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Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice by Russo, Adrian M., Lawther, Adam J., Prior, Benjamin M., Isbel, Luke, Somers, W. Gregory, Lesku, John A., Richdale, Amanda L., Dissanayake, Cheryl, Kent, Stephen, Lowry, Christopher A., Hale, Matthew W.

“…[Display omitted] •BALB/c mice display decreased social behaviour and increased anxiety.•TPH2 activity in BALB/c mice is decreased within the rostral and…”
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Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis by Dominado, Nicole, La Marca, John E., Siddall, Nicole A., Heaney, James, Tran, Mai, Cai, Yu, Yu, Fengwei, Wang, Hongyan, Somers, W. Gregory, Quinn, Leonie M., Hime, Gary R.

“…The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth…”
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Recycling Polarity by Somers, W. Gregory, Chia, William

“…Three current papers in Cell and in this issue of Developmental Cell highlight the role of the exocyst in recycling of membrane proteins from endosomes to the…”
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Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions by Sousa-Nunes, Rita, Somers, W. Gregory

“…Drosophila neuroblasts display remarkable asymmetry throughout mitosis. The most prominent asymmetry is the size difference between daughter cells at…”
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The Pebble GTP Exchange Factor and the Control of Cytokinesis by O'Keefe, Louise, Somers, W. Gregory, Harley, Alyssa, Saint, Robert

“…Several G proteins of the Rho family have been shown to be required for cytokinesis. The activity of these proteins is regulated by GTP exchange factors…”
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Advances in Cytokinesis Research. The Pebble GTP Exchange Factor and the Control of Cytokinesis by O'Keefe, Louise, Somers, W. Gregory, Harley, Alyssa, Saint, Robert

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Phosphotyrosyl phosphatase activator facilitates Miranda localization through dephosphorylation in dividing neuroblasts by Zhang, Fan, Huang, Zhen-Xing, Bao, Hongcun, Cong, Fei, Wang, Huashan, Chai, Phing Chian, Xi, Yongmei, Ge, Wanzhong, Somers, W. Gregory, Yang, Ying, Cai, Yu, Yang, Xiaohang

“…The mechanism for the basal targeting of the Miranda (Mira) complex during the asymmetric division of Drosophila neuroblasts (NBs) is yet to be fully…”
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A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions by Slack, Cathy, Somers, W Gregory, Sousa-Nunes, Rita, Chia, William, Overton, Paul M

“…The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development. In…”
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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating pon by HONGYAN WANG, YINGSHI OUYANG, SOMERS, W. Gregory, CHIA, William, BINGWEI LU

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