Search Results - "Somerman, MJ"

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia by Foster, BL, Nagatomo, KJ, Tso, HW, Tran, AB, Nociti, FH, Narisawa, S, Yadav, MC, McKee, MD, Millán, JL, Somerman, MJ

“…Tissue‐nonspecific alkaline phosphatase (TNAP) is expressed in mineralizing tissues and functions to reduce pyrophosphate (PPi), a potent inhibitor of…”
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Osteopontin regulates dentin and alveolar bone development and mineralization by Foster, B.L., Ao, M., Salmon, C.R., Chavez, M.B., Kolli, T.N., Tran, A.B., Chu, E.Y., Kantovitz, K.R., Yadav, M., Narisawa, S., Millán, J.L., Nociti, F.H., Somerman, M.J.

“…The periodontal complex is essential for tooth attachment and function and includes the mineralized tissues, cementum and alveolar bone, separated by the…”
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The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development by Nagasaki, K., Chavez, M.B., Nagasaki, A., Taylor, J.M., Tan, M.H., Ma, M., Ralston, E., Thew, M.E., Kim, D.-G., Somerman, M.J., Foster, B.L.

“…Bone sialoprotein (gene: Ibsp; protein: BSP) is a multifunctional extracellular matrix protein present in bone, cementum, and dentin. Accumulating evidence…”
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Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations by Foster, B.L., Ramnitz, M.S., Gafni, R.I., Burke, A.B., Boyce, A.M., Lee, J.S., Wright, J.T., Akintoye, S.O., Somerman, M.J., Collins, M.T.

“…Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number…”
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Hypercementosis Associated with ENPP1 Mutations and GACI by Thumbigere-Math, V., Alqadi, A., Chalmers, N.I., Chavez, M.B., Chu, E.Y., Collins, M.T., Ferreira, C.R., FitzGerald, K., Gafni, R.I., Gahl, W.A., Hsu, K.S., Ramnitz, M.S., Somerman, M.J., Ziegler, S.G., Foster, B.L.

“…Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi). Three regulators that…”
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Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering by Osathanon, Thanaphum, Giachelli, Cecilia M, Somerman, Martha J

“…Abstract Alkaline phosphatase (ALP) promotes bone formation by degrading inorganic pyrophosphate (PPi ), an inhibitor of hydroxyapatite formation, and…”
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Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice by Nagasaki, A., Nagasaki, K., Kear, B.D., Tadesse, W.D., Thumbigere-Math, V., Millán, J.L., Foster, B.L., Somerman, M.J.

“…Factors regulating the ratio of pyrophosphate (PPi) to phosphate (Pi) modulate biomineralization. Tissue-nonspecific alkaline phosphatase (TNAP) is a key…”
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Reduced Orthodontic Tooth Movement in Enpp1 Mutant Mice with Hypercementosis by Wolf, M., Ao, M., Chavez, M.B., Kolli, T.N., Thumbigere-Math, V., Becker, K., Chu, E.Y., Jäger, A., Somerman, M.J., Foster, B.L.

“…Previous studies revealed that cementum formation is tightly regulated by inorganic pyrophosphate (PPi), a mineralization inhibitor. Local PPi concentrations…”
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Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia by Foster, B.L., Kuss, P., Yadav, M.C., Kolli, T.N., Narisawa, S., Lukashova, L., Cory, E., Sah, R.L., Somerman, M.J., Millán, J.L.

“…Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes defective skeletal and dental mineralization…”
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Ablation of Pyrophosphate Regulators Promotes Periodontal Regeneration by Nagasaki, A., Nagasaki, K., Chu, E.Y., Kear, B.D., Tadesse, W.D., Ferebee, S.E., Li, L., Foster, B.L., Somerman, M.J.

“…Biomineralization is regulated by inorganic pyrophosphate (PPi), a potent physiological inhibitor of hydroxyapatite crystal growth. Progressive ankylosis…”
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Wnt signaling inhibits cementoblast differentiation and promotes proliferation by Nemoto, Eiji, Koshikawa, Yohei, Kanaya, Sousuke, Tsuchiya, Masahiro, Tamura, Masato, Somerman, Martha J, Shimauchi, Hidetoshi

“…Abstract Cementoblasts, tooth root lining cells, are responsible for laying down cementum on the root surface, a process that is indispensable for establishing…”
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Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering by Osathanon, Thanaphum, Linnes, Michael L, Rajachar, Rupak M, Ratner, Buddy D, Somerman, Martha J, Giachelli, Cecilia M

“…Abstract The fibrotic response of the body to synthetic polymers limits their success in tissue engineering and other applications. Though porous polymers have…”
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Genetic evidence for the vital function of osterix in cementogenesis by Cao, Zhengguo, Zhang, Hua, Zhou, Xin, Han, Xianglong, Ren, Yinshi, Gao, Tian, Xiao, Yin, de Crombrugghe, Benoit, Somerman, Martha J, Feng, Jian Q

“…To date, attempts to regenerate a complete tooth, including the critical periodontal tissues associated with the tooth root, have not been successful…”
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Deficiency in Acellular Cementum and Periodontal Attachment in Bsp Null Mice by Foster, B.L., Soenjaya, Y., Nociti, F.H., Holm, E., Zerfas, P.M., Wimer, H.F., Holdsworth, D.W., Aubin, J.E., Hunter, G.K., Goldberg, H.A., Somerman, M.J.

“…Bone sialoprotein (BSP) is an extracellular matrix protein found in mineralized tissues of the skeleton and dentition. BSP is multifunctional, affecting cell…”
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Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model by Chu, E.Y., Tamasas, B., Fong, H., Foster, B.L., LaCourse, M.R., Tran, A.B., Martin, J.F., Schutte, B.C., Somerman, M.J., Cox, T.C.

“…Clefting of the lip, with or without palatal involvement (CLP), is associated with a higher incidence of developmental tooth abnormalities, including…”
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Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein by Foster, B.L, Ao, M, Willoughby, C, Soenjaya, Y, Holm, E, Lukashova, L, Tran, A.B, Wimer, H.F, Zerfas, P.M, Nociti, F.H, Kantovitz, K.R, Quan, B.D, Sone, E.D, Goldberg, H.A, Somerman, M.J

“…Abstract Bone sialoprotein (BSP) is a multifunctional extracellular matrix protein found in mineralized tissues, including bone, cartilage, tooth root cementum…”
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Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization by McKee, M.D., Yadav, M.C., Foster, B.L., Somerman, M.J., Farquharson, C., Millán, J.L.

“…Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline…”
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Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia by Foster, B.L., Sheen, C.R., Hatch, N.E., Liu, J., Cory, E., Narisawa, S., Kiffer-Moreira, T., Sah, R.L., Whyte, M.P., Somerman, M.J., Millán, J.L.

“…Mutations in ALPL result in hypophosphatasia (HPP), a disease causing defective skeletal mineralization. ALPL encodes tissue nonspecific alkaline phosphatase…”
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Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice by Soenjaya, Y., Foster, B.L., Nociti, F.H., Ao, M., Holdsworth, D.W., Hunter, G.K., Somerman, M.J., Goldberg, H.A.

“…Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding, cell attachment, and hydroxyapatite-nucleating properties. BSP expression in…”
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Fibromodulin and Biglycan Modulate Periodontium through TGFβ/BMP Signaling by Wang, L., Foster, B.L., Kram, V., Nociti, F.H., Zerfas, P.M., Tran, A.B., Young, M.F., Somerman, M.J.

“…A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative…”
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