Search Results - "Somavarapu, S"

Development of Novel Octanoyl Chitosan Nanoparticles for Improved Rifampicin Pulmonary Delivery: Optimization by Factorial Design by Petkar, Kailash C., Chavhan, Sandip, Kunda, N., Saleem, I., Somavarapu, S., Taylor, Kevin M. G., Sawant, Krutika K.

“…A novel hydrophobic chitosan derivative, octanoyl chitosan (OC) with improved organic solubility was synthesized, characterized, and employed for the…”
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A new model for a drying droplet by Sazhin, S.S., Rybdylova, O., Pannala, A.S., Somavarapu, S., Zaripov, S.K.

“…•A new mathematical model for droplet drying.•Analysis of drying of a spray consisting of chitosan dissolved in water.•Validation of the model against…”
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Mono- N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery by Sayın, B., Somavarapu, S., Li, X.W., Thanou, M., Sesardic, D., Alpar, H.O., Şenel, S.

“…Mucosal application of a vaccine can effectively induce both systemic and mucosal immune responses. In general, mucosal applications of antigens result in poor…”
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Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery by Alpar, H. Oya, Somavarapu, S., Atuah, K.N., Bramwell, V.W.

“…Biodegradable polymer and particulate carriers have been shown to be of considerable potential for the delivery of peptides, proteins and DNA in animal models…”
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Intranasal vaccination against plague, tetanus and diphtheria by Alpar, H.O, Eyles, J.E, Williamson, E.D, Somavarapu, S

“…Plague is an extremely virulent and potentially lethal infection caused by the bacterium Y. pestis. The current vaccine used to immunise against plague often…”
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Adjuvant synergy: The effects of nasal coadministration of adjuvants by Moschos, SA, Bramwell, VW, Somavarapu, S, Alpar, HO

“…Modern peptide and protein subunit vaccines suffer from poor immunogenicity and require the use of adjuvants. However, none of the currently licensed adjuvants…”
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Effect of Vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles by Somavarapu, S., Pandit, S., Gradassi, G., Bandera, M., Ravichandran, E., Alpar, Oya H.

“…The nasal mucosa has many advantages as a potential site for drug and vaccine delivery. The present study has sought to exploit this route of delivery using…”
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Immunisation against plague by transcutaneous and intradermal application of subunit antigens by Eyles, J.E., Elvin, S.J., Westwood, A., LeButt, C.S., Alpar, H.O., Somavarapu, S., Williamson, E.D.

“…We have investigated immunological responses in BALB/c mice following transcutaneous (TC) delivery of fraction 1 (F1) and V subunits from Yersinia pestis in…”
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Immobilisation of vaccines onto micro-crystals for enhanced thermal stability by Murdan, S., Somavarapu, S., Ross, Alistair C., Alpar, H.O., Parker, M.C.

“…The thermal instability of many vaccines leads to the wastage of half of all supplied vaccines. In this note, we report the application of a novel technology:…”
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Adjuvant Action of Melittin Following Intranasal Immunisation with Tetanus and Diphtheria Toxoids by Bramwell, V.W., Somavarapu, S., Outschoorn, I., Alpar, H.O.

“…Melittin, a 26-amino acid peptide and the major active component of the venom of the honey bee-Apis mellifera-has recently been shown to have absorption…”
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Nanoparticle agglomerates of indomethacin: The role of poloxamers and matrix former on their dissolution and aerosolisation efficiency by Malamatari, Maria, Somavarapu, Satyanarayana, Bloxham, Mark, Buckton, Graham

“…[Display omitted] Nanoparticles (NPs) were prepared and assembled to microsized agglomerates with and without matrix formers (mannitol and l-leucine) by…”
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Oral Plasmid DNA Delivery Systems for Genetic Immunisation by Somavarapu, S., Bramwell, V.W., Alpar, H.O.

“…The use and optimisation of plasmid DNA delivery systems for the purposes of eliciting transgene specific immune responses to orally administered DNA encoded…”
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Mucosal delivery of diphtheria toxoid using polymer-coated-bioadhesive liposomes as vaccine carriers by Martin, C., Somavarapu, S., Alpar, H.O.

“…The aim of this study was to prepare stable liposomes coated or loaded with bioadhesive polymers and test their efficacy following oral, nasal (IN) or…”
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Preparation of respirable nanoparticle agglomerates of the low melting and ductile drug ibuprofen: Impact of formulation parameters by Malamatari, Maria, Somavarapu, Satyanarayana, Kachrimanis, Kyriakos, Buckton, Graham, Taylor, Kevin M.G.

“…Ductile and low melting point drugs exhibit challenging behaviour during both particle size reduction and spray drying as considerable amount of heat is…”
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Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery by Zariwala, M Gulrez, Bendre, Harshada, Markiv, Anatoliy, Farnaud, Sebastien, Renshaw, Derek, Taylor, Kevin Mg, Somavarapu, Satyanarayana

“…Encapsulation of hydrophilic drugs within liposomes can be challenging. A novel chitosan derivative, O-palmitoyl chitosan (OPC) was synthesized from chitosan…”
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Novel biodegradable poly(gamma-glutamic acid)-amphotericin B complexes show promise as improved amphotericin B formulations by Dinh, T, Zia, Q, Zubair, S, Stapleton, P, Singh, R, Owais, M, Somavarapu, S

“…Abstract Commercially available amphotericin B (AmB) formulations are limited either by cytotoxicities, lower efficacies, shelf-life related issues or high…”
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Chitosan microspheres for nasal delivery of model antigen bovine serum albumin by Somavarapu, S., He, P., Ozsoy, Y., Alpar, H. O.

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Formulation of a microparticle carrier for oral polyplex-based DNA vaccines by Howard, Kenneth A., Li, Xiong Wei, Somavarapu, Satyanarayana, Singh, Jasvinder, Green, Nicky, Atuah, Kwame N., Ozsoy, Yildiz, Seymour, Leonard W., Alpar, H.Oya

“…Oral induction of a disseminated mucosal immune response with polyplex-based DNA vaccines requires the delivery of intact polyplexes (polyelectrolyte complexes…”
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Comparative immunomodulatory properties of a chitosan-MDP adjuvant combination following intranasal or intramuscular immunisation by Moschos, Sterghios A., Bramwell, Vincent W., Somavarapu, Satyanarayna, Alpar, H. Oya

“…As the precise functions of adjuvants become clearer, opportunities are presented in their complementary use for the induction of tailored immune responses to…”
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Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A by Moschos, Sterghios A., Bramwell, Vincent W., Somavarapu, Satyanarayna, Alpar, H. Oya

“…The characterization of the immunological cascades of the innate immune system activated by pathogen associated molecular patterns (PAMP) recognized by pattern…”
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