Search Results - "Soma Kobayashi"

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression by Casanova-Acebes, María, Menéndez-Gutiérrez, María Piedad, Porcuna, Jesús, Álvarez-Errico, Damiana, Lavin, Yonit, García, Ana, Kobayashi, Soma, Le Berichel, Jessica, Núñez, Vanessa, Were, Felipe, Jiménez-Carretero, Daniel, Sánchez-Cabo, Fátima, Merad, Miriam, Ricote, Mercedes

“…Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly…”
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Computational immunohistochemical mapping adds immune context to histological phenotypes in mouse models of colitis by Kobayashi, Soma, Sullivan, Christopher, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

“…Inflammatory bowel disease (IBD) is characterized by chronic, dysregulated inflammation in the gastrointestinal tract. The heterogeneity of IBD is reflected…”
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Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis by Soma Kobayashi, Jason Shieh, Ainara Ruiz de Sabando, Julie Kim, Yang Liu, Sui Y Zee, Prateek Prasanna, Agnieszka B Bialkowska, Joel H Saltz, Vincent W Yang

“…Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract. While therapies exist, response can be limited within the…”
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Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis by Kobayashi, Soma, Shieh, Jason, Ruiz de Sabando, Ainara, Kim, Julie, Liu, Yang, Zee, Sui Y, Prasanna, Prateek, Bialkowska, Agnieszka B, Saltz, Joel H, Yang, Vincent W

“…Inflammatory bowel disease (IBD) is a chronic immune-mediated disease of the gastrointestinal tract. While therapies exist, response can be limited within the…”
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KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model by Shieh, Jason, Chu, Timothy H, Liu, Yang, Kim, Julie, Ruiz de Sabando, Ainara, Kobayashi, Soma, Zee, Sui Y, Sheridan, Brian S, Bialkowska, Agnieszka B, Yang, Vincent W

“…Inflammatory bowel disease (IBD) is a chronic illness characterized by dysregulated immune cascades in the intestines, in which the Th17 immune response plays…”
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Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses by Lavin, Yonit, Kobayashi, Soma, Leader, Andrew, Amir, El-ad David, Elefant, Naama, Bigenwald, Camille, Remark, Romain, Sweeney, Robert, Becker, Christian D., Levine, Jacob H., Meinhof, Klaus, Chow, Andrew, Kim-Shulze, Seunghee, Wolf, Andrea, Medaglia, Chiara, Li, Hanjie, Rytlewski, Julie A., Emerson, Ryan O., Solovyov, Alexander, Greenbaum, Benjamin D., Sanders, Catherine, Vignali, Marissa, Beasley, Mary Beth, Flores, Raja, Gnjatic, Sacha, Pe’er, Dana, Rahman, Adeeb, Amit, Ido, Merad, Miriam

“…To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the…”
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Computational Approach to Define Histological Phenotypes Across Colitis Mouse Models by Kobayashi, Soma

“…Colitis mouse models have played an integral role in advancing our knowledge of human Inflammatory Bowel Disease. Colitis mouse models develop specific…”
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State of machine and deep learning in histopathological applications in digestive diseases by Kobayashi, Soma, Saltz, Joel H, Yang, Vincent W

“…Machine learning (ML)- and deep learning (DL)-based imaging modalities have exhibited the capacity to handle extremely high dimensional data for a number of…”
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Mo1644: A DEEP LEARNING-BASED APPROACH TO IDENTIFY PATHOLOGIES IN MOUSE MODELS OF COLITIS by Kobayashi, Soma, Shieh, Jason, Sabando, Ainara Ruiz de, Prasanna, Prateek, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

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Tu1991 COMPUTATIONAL MAPPING OF IMMUNOHISTOCHEMICAL MARKER POSITIVITY TO H&E-DETECTED HISTOLOGICAL ABNORMALITIES ACROSS MOUSE MODELS OF COLITIS by Kobayashi, Soma, Sullivan, Chris, De Sabando, Ainara Ruiz, Zee, Sui Y., Prasanna, Prateek, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

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Fr619 DEEP LEARNING CLASSIFIER TO DETECT INFLAMED AND NON-INFLAMED AREAS WITHIN WHOLE MOUSE COLONS by Kobayashi, Soma, Shieh, Jason, de Sabando, Ainara Ruiz, Bialkowska, Agnieszka B., Saltz, Joel H., Yang, Vincent W.

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Mo1352: IL-17A AND THE MICROBIOTA ARE ESSENTIAL FOR THE INITATION OF ACUTE INFLAMMATION IN MICE WITH INTESTINE-SECIFIC DELETION OF KRÜPPEL-LIKE FACTOR 5 by Shieh, Jason, Kobayashi, Soma, Liu, Yang, Chu, Timothy H., Kim, Julie M., Sabando, Ainara Ruiz De, Sheridan, Brian S., Bialkowska, Agnieszka B., Yang, Vincent W.

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Su1151 DEEP LEARNING FOR HISTOLOGICAL ANALYSIS OF TUMOR-LYMPHOCYTE INTERACTIONS IN PANCREATIC DUCTAL ADENOCARCINOMA by Kobayashi, Soma, Le, Han, Chrastecka, Lucie, Gupta, Rajarsi, Hou, Le, Abousamra, Shahira, Fassler, Danielle, Shroyer, Kenneth R., Samaras, Dimitris, Moffitt, Richard A., Saltz, Joel H.

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Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression by Fassler, Danielle J, Torre-Healy, Luke A, Gupta, Rajarsi, Hamilton, Alina M, Kobayashi, Soma, Van Alsten, Sarah C, Zhang, Yuwei, Kurc, Tahsin, Moffitt, Richard A, Troester, Melissa A, Hoadley, Katherine A, Saltz, Joel

“…Tumor-infiltrating lymphocytes (TILs) have been established as a robust prognostic biomarker in breast cancer, with emerging utility in predicting treatment…”
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Abstract A27: Deep learning for analysis of tumor-lymphocyte interactions in pancreatic ductal adenocarcinoma by Kobayashi, Soma, Le, Han, Chrastecka, Lucie, Gupta, Rajarsi, Hou, Le, Abousamra, Shahira, Fassler, Danielle, Shroyer, Kenneth R., Samaras, Dimitris, Kurc, Tahsin, Moffitt, Richard A., Saltz, Joel H.

“…Abstract The interaction of tumor, stroma, and immune cells in pancreatic ductal adenocarcinoma (PDAC) is complex and difficult to quantify in patient samples…”
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High‐dimensional single cell mapping of cerium distribution in the lung immune microenvironment of an active smoker by Rahman, Adeeb H., Lavin, Yonit, Kobayashi, Soma, Leader, Andrew, Merad, Miriam

“…Background Mass cytometry leverages inductively coupled mass spectrometry to perform high dimensional single cell analyses using antibodies tagged with rare…”
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Abstract B065: Biomarker approach to define tumor subtype in pancreatic ductal adenocarcinoma by Ho, Carson, Horowitz, Michael, Oblein, Lyanne, Sarkar, Shayan, Kobayashi, Soma, Bai, Karen, Marchenko, Natalia, Escobar-Hoyos, Luisa, Shroyer, Kenneth

“…Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors with a predicted five-year survival rate in 2023 of 12%. Building…”
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AI and Pathology: Steering Treatment and Predicting Outcomes by Gupta, Rajarsi, Kaczmarzyk, Jakub, Kobayashi, Soma, Kurc, Tahsin, Saltz, Joel

“…The combination of data analysis methods, increasing computing capacity, and improved sensors enable quantitative granular, multi-scale, cell-based analyses…”
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