Search Results - "Soma, Kaori"
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Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification
Published in Scientific reports (18-11-2022)“…Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tissue-nonspecific…”
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Comparison of chest compression quality in walking versus straddling cardiopulmonary resuscitation during stretcher transportation: A prospective randomised crossover study using manikins
Published in PloS one (21-05-2019)“…The optimal strategy to ensure chest compression quality for patients being transported on a stretcher has not been established yet. We hypothesised that…”
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Abundant expression of KCNE1 in the left ventricle of the miniature pig
Published in Heart and vessels (01-05-2011)“…Delayed rectifier potassium currents such as I Kr and I Ks play an important role in the repolarization phase of the action potential in cardiac myocytes…”
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In Vitro and In Vivo Pharmacological Profiles of DS‐1211, a Novel Potent, Selective, and Orally Bioavailable Tissue‐Nonspecific Alkaline Phosphatase Inhibitor
Published in Journal of bone and mineral research (01-10-2022)“…ABSTRACT Inhibition of tissue‐nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate…”
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5
Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure
Published in Bioorganic & medicinal chemistry letters (01-03-2022)“…[Display omitted] Motilin is a 22-amino-acid gastrointestinal (GI) hormone and is involved in the regulation of GI motility through binding to GPR38, the…”
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