Search Results - "Som, Tina"

Cabozantinib is well tolerated in acute myeloid leukemia and effectively inhibits the resistance‐conferring FLT3/tyrosine kinase domain/F691 mutation by Fathi, Amir T., Blonquist, Traci M., Hernandez, Daniela, Amrein, Philip C., Ballen, Karen K., McMasters, Malgorzata, Avigan, David E., Joyce, Robin, Logan, Emma K., Hobbs, Gabriela, Brunner, Andrew M., Joseph, Christelle, Perry, Ashley M., Burke, Meghan, Behnan, Tanya, Foster, Julia, Bergeron, Meghan K., Moran, Jenna A., Ramos, Aura Y., Som, Tina T., Rae, Jessica, Fishman, Kaitlyn M., McGregor, Kristin L., Connolly, Christine, Neuberg, Donna S., Levis, Mark J.

“…BACKGROUND Cabozantinib, a tyrosine kinase inhibitor of FMS‐like tyrosine kinase 3 (FLT3), MET, AXL, vascular endothelial growth factor receptor, and KIT, is…”
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A phase 1 study of the antibody‐drug conjugate brentuximab vedotin with re‐induction chemotherapy in patients with CD30‐expressing relapsed/refractory acute myeloid leukemia by Narayan, Rupa, Blonquist, Traci M., Emadi, Ashkan, Hasserjian, Robert P., Burke, Meghan, Lescinskas, Christopher, Neuberg, Donna S., Brunner, Andrew M., Hobbs, Gabriela, Hock, Hanno, McAfee, Steven L., Chen, Yi‐Bin, Attar, Eyal, Graubert, Timothy A., Bertoli, Christina, Moran, Jenna A., Bergeron, Meghan K., Foster, Julia E., Ramos, Aura Y., Som, Tina T., Vartanian, Megan K., Story, Jennifer L., McGregor, Kristin, Macrae, Molly, Behnan, Tanya, Wey, Margaret C., Rae, Jessica, Preffer, Frederic I., Lesho, Patricia, Duong, Vu H., Mann, Mason L., Ballen, Karen K., Connolly, Christine, Amrein, Philip C., Fathi, Amir T.

“…Background Outcomes for patients with relapsed/refractory acute myeloid leukemia (R/R AML) remain poor. Novel therapies specifically targeting AML are of high…”
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Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia by Fathi, Amir T, Wander, Seth A, Blonquist, Traci M, Brunner, Andrew M, Amrein, Philip C, Supko, Jeffrey, Hermance, Nicole M, Manning, Amity L, Sadrzadeh, Hossein, Ballen, Karen K, Attar, Eyal C, Graubert, Timothy A, Hobbs, Gabriela, Joseph, Christelle, Perry, Ashley M, Burke, Meghan, Silver, Regina, Foster, Julia, Bergeron, Meghan, Ramos, Aura Y, Som, Tina T, Fishman, Kaitlyn M, McGregor, Kristin L, Connolly, Christine, Neuberg, Donna S, Chen, Yi-Bin

“…Aberrant expression of aurora kinase A is implicated in the genesis of various neoplasms, including acute myeloid leukemia. Alisertib, an aurora A kinase…”
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Targeted FGFR inhibition results in a durable remission in an FGFR1-driven myeloid neoplasm with eosinophilia by Kasbekar, Monica, Nardi, Valentina, Dal Cin, Paola, Brunner, Andrew M., Burke, Meghan, Chen, Yi-Bin, Connolly, Christine, Fathi, Amir T., Foster, Julia, Macrae, Molly, McAfee, Steven L., McGregor, Kristin, Narayan, Rupa, Ramos, Aura Y., Som, Tina T., Vartanian, Meghan, Friedman, Robb S., Benhadji, Karim A., Hobbs, Gabriela S.

“…•A novel PCM1-FGFR1 gene rearrangement was identified in a patient with a myeloid neoplasm with eosinophilia.•Futibatinib, an oral selective small molecule…”
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Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial by Brunner, Andrew M, Blonquist, Traci M, DeAngelo, Daniel J, McMasters, Malgorzata, Fell, Geoffrey, Hermance, Nicole M, Winer, Eric S, Lindsley, R Coleman, Hobbs, Gabriela S, Amrein, Philip C, Hock, Hanno R, Steensma, David P, Garcia, Jacqueline S, Luskin, Marlise R, Stone, Richard M, Ballen, Karen K, Rosenblatt, Jacalyn, Avigan, David, Nahas, Myrna R, Mendez, Lourdes M, McAfee, Steven L, Moran, Jenna A, Bergeron, Meghan, Foster, Julia, Bertoli, Christina, Manning, Amity L, McGregor, Kristin L, Fishman, Kaitlyn M, Kuo, Frank C, Baltay, Michele T, Macrae, Molly, Burke, Meghan, Behnan, Tanya, Wey, Margaret C, Som, Tina T, Ramos, Aura Y, Rae, Jessica, Lombardi Story, Jennifer, Nelson, Nicole, Logan, Emma, Connolly, Christine, Neuberg, Donna S, Chen, Yi-Bin, Graubert, Timothy A, Fathi, Amir T

“…Increased aurora A kinase (AAK) expression occurs in acute myeloid leukaemia; AAK inhibition is a promising therapeutic target in this disease. We therefore…”
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A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies by How, Joan, Ren, Siyang, Lombardi‐Story, Jennifer, Bergeron, Meghan, Foster, Julia, Amrein, Phillip C., Brunner, Andrew M., Fathi, Amir T., Hock, Hanno, Khachatryan, Anna, Kikuchi, Hiroto, Ng, Mei Rosa, Moran, Jenna, Narayan, Rupa, Neuberg, Donna, Ramos, Aura, Som, Tina, Vartanian, Meghan, Chen, Yi‐Bin, Duda, Dan G., Hobbs, Gabriela S.

“…We conducted a single‐center, open‐label, dose escalation, and expansion phase I trial of the antiangiogenic multikinase inhibitor regorafenib in patients with…”
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Phase I Study of Ixazomib with Conventional Chemotherapy in the Treatment of Acute Myeloid Leukemia in Older Adults by Amrein, Philip C., Attar, Eyal C., Fell, Geoffrey G, Blonquist, Traci M., Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno R., McAfee, Steven, Narayan, Rupa, Moran, Jenna A., Bergeron, Meghan, Foster, Julia E., Bertoli, Christina, McGregor, Kristin, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Neuberg, Donna S., Fathi, Amir T.

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Results of a Phase II Study of PD-1 Inhibition in Advanced Myeloproliferative Neoplasms by Hobbs, Gabriela S., Cimen Bozkus, Cansu, Wadleigh, Martha, Sandy, Lonette, Doughtery, Mikaela, Johnson, Kathryn, Sanchez, Gillian, Foster, Julia E., Macrae, Molly, Som, Tina T., Bar-Natan, Michal, Stone, Richard M., Moshier, Erin, Iancu-Rubin, Camelia, Mascarenhas, John

“…Background: Myelofibrosis (MF) is a hematopoietic stem cell neoplasm characterized by abnormal JAK-STAT signaling, increased inflammation, and evolution to…”
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Ixazomib in addition to chemotherapy for the treatment of acute lymphoblastic leukemia in older adults by Amrein, Philip, Ballen, Karen, Stevenson, Kristen, Brunner, Andrew, Hobbs, Gabriela, Hock, Hanno, McAfee, Steven, Moran, Jenna, Bergeron, Meghan, Foster, Julia, Bertoli, Christina, McGreggor, Kristin, Macrea, Molly, Burke, Meghan, Behnam, Tanya, Som, Tina, Ramos, Aura, Vartanian, Megan, Lombardi Story, Jennifer, Connolly, Christine, Blonquist, Traci, Neuberg, Donna, Fathi, Amir

“…We sought to assess the safety of adding ixazomib, an oral proteasome inhibitor, to a multi-agent treatment regimen for older adults with acute lymphoblastic…”
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Phase I Study of Ixazomib Added to Chemotherapy in the Treatment of Acute Lymphoblastic Leukemia in Older Adults by Amrein, Philip C., Ballen, Karen K., Stevenson, Kristen E., Blonquist, Traci M., Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno R., McAfee, Steven L., Moran, Jenna A., Bergeron, Meghan, Foster, Julia E., Bertoli, Christina, McGregor, Kristin, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Connolly, Christine, Graubert, Timothy A., Neuberg, Donna S., Fathi, Amir T.

“…Introduction: While progress has been made in the treatment of childhood leukemia, the outlook for patients >60 years of age with acute lymphoblastic leukemia…”
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Phase I Study of Ixazomib with Conventional Chemotherapy in the Treatment of Acute Myeloid Leukemia in Older Adults by Amrein, Philip C., Attar, Eyal C., Fell, Geoffrey, Blonquist, Traci M., Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno R., McAfee, Steven L., Narayan, Rupa, Moran, Jenna A., Bergeron, Meghan, Foster, Julia E., Bertoli, Christina, McGregor, Kristin, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Neuberg, Donna S., Fathi, Amir T.

“…Introduction: Outcomes for acute myeloid leukemia (AML) among older patients has remained largely unchanged for decades. Long-term survival for patients aged…”
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A Phase 1 Trial of Regorafenib in Advanced Myeloid Malignancies by How, Chi-Joan, Ren, Siyang, Lombardi Story, Jennifer, Bergeron, Meghan, Foster, Julia E., Amrein, Philip C., Brunner, Andrew M., Fathi, Amir T., Hock, Hanno R., Moran, Jenna A., Narayan, Rupa, Neuberg, Donna S., Ramos, Aura Y., Som, Tina T., Vartanian, Megan, Chen, Yi-Bin, Hobbs, Gabriela S.

“…Angiogenesis is increasingly known to play a role in pathogenesis of hematologic malignancies, including myeloid neoplasms. Regorafenib is a multikinase…”
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Targeted FGFR Inhibition Results in Hematologic and Cytogenetic Remission in a Myeloid Neoplasm Driven By a Novel PCM1-FGFR1 Fusion: Data from an Expanded Access Program by Kasbekar, Monica, Nardi, Valentina, Dal Cin, Paola, Brunner, Andrew M., Chen, Yi-Bin, Connolly, Christine, Fathi, Amir T., Foster, Julia, Macrae, Molly, McAfee, Steven L, McGregor, Kristin, Narayan, Rupa, Ramos, Aura Y., Som, Tina T., Vartanian, Megan, Friedman, Robb S, Benhadji, Karim, Hobbs, Gabriela S.

“…Introduction In 2008, the World Health Organization defined a new classification of myeloid and lymphoid neoplasms with eosinophilia that result from gene…”
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PD-1 inhibition in advanced myeloproliferative neoplasms by Hobbs, Gabriela, Cimen Bozkus, Cansu, Moshier, Erin, Dougherty, Mikaela, Bar-Natan, Michal, Sandy, Lonette, Johnson, Kathryn, Foster, Julia Elise, Som, Tina, Macrae, Molly, Marble, Hetal, Salama, Mohamed, El Jamal, Siraj M., Zubizarreta, Nicole, Wadleigh, Martha, Stone, Richard, Bhardwaj, Nina, Iancu-Rubin, Camelia, Mascarenhas, John

“…Myelofibrosis (MF) is a clonal stem cell neoplasm characterized by abnormal JAK-STAT signaling, chronic inflammation, cytopenias, and risk of transformation to…”
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Phase I Study of Ixazomib in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults by Amrein, Philip C., Ballen, Karen K., Blonquist, Traci M., Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno, McAfee, Steven L, Moran, Jenna A., Bergeron, Meghan, Foster, Julia, Bertoli, Christina, McGregor, Kristin, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Connolly, Christine, Neuberg, Donna S, Fathi, Amir T.

“…Introduction: While progress has been made in the treatment of childhood leukemia, the outlook for patients >60 years of age with acute lymphoblastic leukemia…”
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Phase I Study of Ixazomib in Addition to Chemotherapy for the Treatment of Acute Myeloid Leukemia in Older Adults by Amrein, Philip C., Attar, Eyal C., Blonquist, Traci M., Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno, McAfee, Steven, Moran, Jenna A., Bergeron, Meghan, Foster, Julia, Bertoli, Christina, McGregor, Kristin, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Neuberg, Donna S, Fathi, Amir T.

“…Introduction: Treatment of acute myeloid leukemia (AML) has remained largely unchanged for several decades despite the emergence of new agents. Long-term…”
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Phase I Study of the Antibody-Drug Conjugate Brentuximab Vedotin Combined with Re-Induction Chemotherapy in Patients with CD30-Expressing Relapsed/Refractory Acute Myeloid Leukemia by Fathi, Amir T., Blonquist, Traci M., Emadi, Ashkan, Brunner, Andrew M., Hobbs, Gabriela S., Hock, Hanno, McAfee, Steven L, Hasserjian, Robert P., Preffer, Frederic I., Moran, Jenna A., Bergeron, Meghan, Foster, Julia, Bertoli, Christina, McGregor, Kristin, Fishman, Kaitlyn, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Lombardi Story, Jennifer, Lesho, Patricia, Duong, Vu H., Mann, Mason, Lescinskas, Christopher, Connolly, Christine, Neuberg, Donna S, Ballen, Karen K., Amrein, Philip C.

“…Background: Brentuximab vedotin (BV) is an antibody-drug conjugate (ADC) consisting of an antibody specific for human CD30, an anti-microtubule agent…”
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Phase II Clinical Trial of Alisertib, an Aurora a Kinase Inhibitor, in Combination with Induction Chemotherapy in High-Risk, Untreated Patients with Acute Myeloid Leukemia by Brunner, Andrew M., Blonquist, Traci M., DeAngelo, Daniel J., McMasters, Malgorzata, Winer, Eric S., Hobbs, Gabriela S., Amrein, Philip C., Hock, Hanno, Steensma, David P., Garcia, Jacqueline S., Luskin, Marlise R., Stone, Richard M., Ballen, Karen K., Rosenblatt, Jacalyn, Avigan, David E., McAfee, Steven L, Moran, Jenna A., Bergeron, Meghan, Foster, Julia, Bertoli, Christina, McGregor, Kristin, Fishman, Kaitlyn, Macrae, Molly, Burke, Meghan, Behnan, Tanya T., Som, Tina T., Ramos, Aura Y., Vartanian, Megan K., Nelson, Nicole, Logan, Emma, Lombardi Story, Jennifer, Connolly, Christine, Neuberg, Donna S, Chen, Yi-Bin, Graubert, Timothy A., Fathi, Amir T.

“…▪ Background: Aurora kinases play essential roles in regulating cell division, and increased expression has been noted in myelodysplastic syndromes (MDS) and…”
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A Phase I Study of the Multi-Targeted Tyrosine Kinase Inhibitor Cabozantinib in Patients with Acute Myeloid Leukemia by Fathi, Amir T., Blonquist, Traci M., Levis, Mark J., Hernandez, Daniela, Ballen, Karen K., Avigan, David E., Joyce, Robin, McMasters, Malgorzata, Logan, Emma, Hobbs, Gabriela S., Brunner, Andrew M., Connolly, Christine, Perry, Ashley M., Joseph, Christelle, Som, Tina T., Ramos, Aura Y., Neuberg, Donna S., Amrein, Philip C.

“…Cabozantinib is a multi-targeted tyrosine kinase inhibitor (TKI) of FLT3, MET, AXL, VEGFR, and KIT, all of which are implicated in the pathogenesis of acute…”
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