Search Results - "Solus, Joseph"

Role of inflammation and oxidative stress in atrial fibrillation by Li, Jie, MD, Solus, Joseph, PhD, Chen, Qingxia, PhD, Rho, Young Hee, MD, PhD, Milne, Ginger, PhD, Stein, C. Michael, MD, Darbar, Dawood, MD

“…Background Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice. Increasing evidence indicates that inflammation and oxidative…”
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ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants by O’Neill, Matthew J., Yang, Tao, Laudeman, Julie, Calandranis, Maria E., Harvey, M. Lorena, Solus, Joseph F., Roden, Dan M., Glazer, Andrew M.

“…Interpreting the clinical significance of putative splice-altering variants outside canonical splice sites remains difficult without time-intensive…”
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The electrophysiologic effects of KCNQ1 extend beyond expression of IKs: evidence from genetic and pharmacologic block by Wada, Yuko, Wang, Lili, Hall, Lynn D, Yang, Tao, Short, Laura L, Solus, Joseph F, Glazer, Andrew M, Roden, Dan M

“…While variants in KCNQ1 are the commonest cause of the congenital long QT syndrome, we and others find only a small IKs in cardiomyocytes from human-induced…”
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Brief Report: The Ability of the 2013 American College of Cardiology/American Heart Association Cardiovascular Risk Score to Identify Rheumatoid Arthritis Patients With High Coronary Artery Calcification Scores by Kawai, Vivian K., Chung, Cecilia P., Solus, Joseph F., Oeser, Annette, Raggi, Paolo, Stein, C. Michael

“…Objective Patients with rheumatoid arthritis (RA) have increased risk of atherosclerotic cardiovascular disease that is underestimated by the Framingham Risk…”
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The ability of the 2013 American College of Cardiology/American Heart Association cardiovascular risk score to identify rheumatoid arthritis patients with high coronary artery calcification scores by Kawai, Vivian K, Chung, Cecilia P, Solus, Joseph F, Oeser, Annette, Raggi, Paolo, Stein, C Michael

“…Patients with rheumatoid arthritis (RA) have increased risk of atherosclerotic cardiovascular disease that is underestimated by the Framingham Risk Score…”
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Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls by Ormseth, Michelle J, Solus, Joseph F, Sheng, Quanhu, Ye, Fei, Wu, Qiong, Guo, Yan, Oeser, Annette M, Allen, Ryan M, Vickers, Kasey C, Stein, C Michael

“…MicroRNA (miRNA) are short noncoding RNA that regulate genes and are both biomarkers and mediators of disease. We used small RNA (sRNA) sequencing and machine…”
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Dominant negative effects of SCN5A missense variants by O’Neill, Matthew J., Muhammad, Ayesha, Li, Bian, Wada, Yuko, Hall, Lynn, Solus, Joseph F., Short, Laura, Roden, Dan M., Glazer, Andrew M.

“…Up to 30% of patients with Brugada syndrome (BrS) carry loss-of-function (LoF) variants in the cardiac sodium channel gene SCN5A encoding for the protein…”
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Utility of Select Plasma MicroRNA for Disease and Cardiovascular Risk Assessment in Patients with Rheumatoid Arthritis by Ormseth, Michelle J, Solus, Joseph F, Vickers, Kasey C, Oeser, Annette M, Raggi, Paolo, Stein, C Michael

“…MicroRNA (miRNA) are small noncoding RNA that posttranscriptionally regulate gene expression and serve as potential mediators and markers of disease. Recently,…”
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Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis by Chung, Cecilia P, Oeser, Annette, Solus, Joseph F, Avalos, Ingrid, Gebretsadik, Tebeb, Shintani, Ayumi, Raggi, Paolo, Sokka, Tuulikki, Pincus, Theodore, Stein, C. Michael

“…Abstract Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. The metabolic syndrome, a cluster of cardiovascular risk factors, identifies…”
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Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease by Kropski, Jonathan A, Pritchett, Jason M, Zoz, Donald F, Crossno, Peter F, Markin, Cheryl, Garnett, Errine T, Degryse, Amber L, Mitchell, Daphne B, Polosukhin, Vasiliy V, Rickman, Otis B, Choi, Leena, Cheng, Dong-Sheng, McConaha, Melinda E, Jones, Brittany R, Gleaves, Linda A, McMahon, Frank B, Worrell, John A, Solus, Joseph F, Ware, Lorraine B, Lee, Jae Woo, Massion, Pierre P, Zaynagetdinov, Rinat, White, Eric S, Kurtis, Jonathan D, Johnson, Joyce E, Groshong, Steve D, Lancaster, Lisa H, Young, Lisa R, Steele, Mark P, Phillips Iii, John A, Cogan, Joy D, Loyd, James E, Lawson, William E, Blackwell, Timothy S

“…Asymptomatic relatives of patients with familial interstitial pneumonia (FIP), the inherited form of idiopathic interstitial pneumonia, carry increased risk…”
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Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis by Ormseth, Michelle J., Solus, Joseph F., Sheng, Quanhu, Chen, Sheau-Chiann, Ye, Fei, Wu, Qiong, Oeser, Annette M., Allen, Ryan, Raggi, Paolo, Vickers, Kasey C., Stein, C. Michael

“…Objective MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading…”
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Utility of a novel inflammatory marker, GlycA, for assessment of rheumatoid arthritis disease activity and coronary atherosclerosis by Ormseth, Michelle J, Chung, Cecilia P, Oeser, Annette M, Connelly, Margery A, Sokka, Tuulikki, Raggi, Paolo, Solus, Joseph F, Otvos, James D, Stein, C Michael

“…GlycA is a novel inflammatory biomarker measured using nuclear magnetic resonance (NMR). Its NMR signal primarily represents glycosylated acute phase proteins…”
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Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant by O’Neill, Matthew J., Chen, Suet Nee, Rumping, Lynne, Johnson, Renee, van Slegtenhorst, Marjon, Glazer, Andrew M., Yang, Tao, Solus, Joseph F., Laudeman, Julie, Mitchell, Devyn W., Vanags, Loren R., Kroncke, Brett M., Anderson, Katherine, Gao, Shanshan, Verdonschot, Job A.J., Brunner, Han, Hellebrekers, Debby, Taylor, Matthew R.G., Roden, Dan M., Wessels, Marja W., Lekanne Dit Deprez, Ronald H., Fatkin, Diane, Mestroni, Luisa, Shoemaker, M. Benjamin

“…Truncating variants in filamin C (FLNC) can cause arrhythmogenic cardiomyopathy (ACM) through haploinsufficiency. Noncanonical splice-altering variants may…”
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MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome by Rogers, Angela J, Solus, Joseph F, Hunninghake, Gary M, Baron, Rebecca M, Meyer, Nuala J, Janz, David R, Schwartz, David A, May, Addison K, Lawson, William E, Blackwell, Timothy S, Ware, Lorraine B

“…Patients with interstitial abnormalities have been found to be at increased risk of ARDS (3). [...]we hypothesized that MUC5B risk allele carriers over age 50…”
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A variant in the osteoprotegerin gene is associated with coronary atherosclerosis in patients with rheumatoid arthritis: results from a candidate gene study by Chung, Cecilia P, Solus, Joseph F, Oeser, Annette, Li, Chun, Raggi, Paolo, Smith, Jeffrey R, Stein, C Michael

“…Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis, but there is limited information about the genetic contribution to atherosclerosis in…”
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Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis by Solus, Joseph F., Chung, Cecilia P., Oeser, Annette, Li, Chun, Rho, Young Hee, Bradley, Kevin M., Kawai, Vivian K., Smith, Jeffrey R., Stein, C. Michael

“…Elevated concentrations of inflammatory mediators are characteristic of autoimmune disease accompanied by chronic or recurrent inflammation. We examined the…”
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Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis by Ormseth, Michelle J, Solus, Joseph F, Oeser, Annette M, Bian, Aihua, Gebretsadik, Tebeb, Shintani, Ayumi, Raggi, Paolo, Stein, C Michael

“…Telomeres protect against chromosomal end damage and shorten with each cell division; their length may be a marker of cardiovascular and overall biological…”
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Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High‐Density Lipoprotein–Enriched Serum in Rheumatoid Arthritis by Ormseth, Michelle J., Yancey, Patricia G., Solus, Joseph F., Bridges, S. Louis, Curtis, Jeffrey R., Linton, MacRae F., Fazio, Sergio, Davies, Sean S., Roberts, L. Jackson, Vickers, Kasey C., Kon, Valentina, Michael Stein, C., Bingham, Clifton O., Cofield, Stacey S., Furie, Richard, Gregersen, Peter K., Genovese, Mark C., Robinson, William H., Levesque, Marc C., Moreland, Larry W., Nigrovic, Peter A., Shadick, Nancy A., O'Dell, James R., Thiele, Geoffrey M., St.Clair, E. William, Striebich, Christopher C.

“…Objective Patients with rheumatoid arthritis (RA) have an increased risk of coronary heart disease (CHD). Some RA therapies may modify this risk, but the…”
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Effect of Omega-Three Polyunsaturated Fatty Acids on Inflammation, Oxidative Stress, and Recurrence of Atrial Fibrillation by Darghosian, Leon, MD, Free, Marcia, RN, Li, Jie, MD, Gebretsadik, Tebeb, MPH, Bian, Aihua, MPH, Shintani, Ayumi, PhD, MPH, McBride, Brian F., PharmD, Solus, Joseph, PhD, Milne, Ginger, PhD, Crossley, George H., MD, Thompson, David, MD, Vidaillet, Humberto, MD, Okafor, Henry, MD, Darbar, Dawood, MD, Murray, Katherine T., MD, Stein, C. Michael, MBChB

“…The efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in preventing recurrence of atrial fibrillation (AF) is controversial and their effects on…”
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Inflammation and Hypertension in Rheumatoid Arthritis by MANAVATHONGCHAI, Siriporn, AIHUA BIAN, YOUNG HEE RHO, OESER, Annette, SOLUS, Joseph F, GEBRETSADIK, Tebeb, SHINTANI, Ayumi, MICHAEL STEIN, C

“…Hypertension (HTN), a common modifiable cardiovascular risk factor, is more common in patients with rheumatoid arthritis (RA), but the underlying mechanisms…”
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