Search Results - "Solst, Shane R"

The mechanism of cell death induced by silver nanoparticles is distinct from silver cations by Rohde, Monica M, Snyder, Christina M, Sloop, John, Solst, Shane R, Donati, George L, Spitz, Douglas R, Furdui, Cristina M, Singh, Ravi

“…Precisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver…”
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Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism by Rodman, Samuel N., Spence, Jacquelyn M., Ronnfeldt, Tyler J., Zhu, Yueming, Solst, Shane R., O'Neill, Rebecca A., Allen, Bryan G., Guan, Xiangming, Spitz, Douglas R., Fath, Melissa A.

“…The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation…”
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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis by Tompkins, Sean C., Sheldon, Ryan D., Rauckhorst, Adam J., Noterman, Maria F., Solst, Shane R., Buchanan, Jane L., Mapuskar, Kranti A., Pewa, Alvin D., Gray, Lawrence R., Oonthonpan, Lalita, Sharma, Arpit, Scerbo, Diego A., Dupuy, Adam J., Spitz, Douglas R., Taylor, Eric B.

“…Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the liver Mitochondrial…”
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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth by Johnson, Spenser S, Liu, Dijie, Ewald, Jordan T, Robles-Planells, Claudia, Pulliam, Casey, Christensen, Keegan A, Bayanbold, Khaliunaa, Wels, Brian R, Solst, Shane R, O'Dorisio, M Sue, Menda, Yusuf, Spitz, Douglas R, Fath, Melissa A

“…Thioredoxin Reductase (TrxR) functions to recycle thioredoxin (Trx) during hydroperoxide metabolism mediated by peroxiredoxins and is currently being targeted…”
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Additive Effects of Cu-ATSM and Radiation on Survival of Diffuse Intrinsic Pontine Glioma Cells by King, Sarah A., Solst, Shane R., Graham, Claire H., Fiore, Lianna Z., Rheem, Rana, Tomanek-Chalkley, Ann, Fath, Melissa A., Caster, Joseph M., Spitz, Douglas R., Howard, Michelle E.

“…Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive and treatment-resistant childhood primary brainstem tumors with a median survival of less than…”
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Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper by Falls-Hubert, Kelly C., Butler, Aimee L., Gui, Kai, Anderson, Michael, Li, Mengshi, Stolwijk, Jeffrey M., Rodman, Samuel N., Solst, Shane R., Tomanek-Chalkley, Ann, Searby, Charles C., Sheffield, Val C., Sandfort, Vanessa, Schmidt, Hartmut, McCormick, Michael L., Wels, Brian R., Allen, Bryan G., Buettner, Garry R., Schultz, Michael K., Spitz, Douglas R.

“…Therapies for lung cancer patients initially elicit desirable responses, but the presence of hypoxia and drug resistant cells within tumors ultimately lead to…”
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Rapid Peroxide Removal Limits the Radiosensitization of Diffuse Intrinsic Pontine Glioma (DIPG) Cells by Pharmacologic Ascorbate by Solst, Shane R., Mapuskar, Kranti A., Graham, Claire H., King, Sarah A., Rheem, Rana, Current, Kyle, Allen, Bryan G., Caster, Joseph M., Spitz, Douglas R., Howard, Michelle E.

“…Diffuse intrinsic pontine gliomas (DIPG) are an aggressive type of pediatric brain tumor with a very high mortality rate. Surgery has a limited role given the…”
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D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress by Sciegienka, Sebastian J., Solst, Shane R., Falls, Kelly C., Schoenfeld, Joshua D., Klinger, Adrienne R., Ross, Natalie L., Rodman, Samuel N., Spitz, Douglas R., Fath, Melissa A.

“…D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests…”
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How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies by Piccirillo, Sarah, McCune, Abbigail H, Dedert, Samuel R, Kempf, Cassandra G, Jimenez, Brian, Solst, Shane R, Tiede-Lewis, LeAnn M, Honigberg, Saul M

“…Under conditions in which budding yeast form colonies and then undergo meiosis/sporulation, the resulting colonies are organized such that a sharply defined…”
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D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H 2 O 2 -mediated oxidative stress by Sciegienka, Sebastian J, Solst, Shane R, Falls, Kelly C, Schoenfeld, Joshua D, Klinger, Adrienne R, Ross, Natalie L, Rodman, Samuel N, Spitz, Douglas R, Fath, Melissa A

“…D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests…”
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Abstract 3527: Inhibition of mitochondrial pyruvate transport selectively sensitizes cancer cells to metabolic oxidative stress by Solst, Shane R., Rodman, Samuel N., Fath, Melissa A., Taylor, Eric B., Spitz, Douglas R.

“…Abstract To determine if mitochondrial pyruvate transport could represent a therapeutic target for sensitizing cancer cells to oxidative stress, lung and…”
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Inhibition of Mitochondrial Pyruvate Transport Selectively Sensitizes Cancer Cells to Metabolic Oxidative Stress by Solst, Shane R, Rodman, Samuel N, Fath, Melissa A, Taylor, Eric B, Spitz, Douglas R

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141 - Inhibition of Mitochondrial Pyruvate Transport Selectively Sensitizes Cancer Cells to Metabolic Oxidative Stress by Solst, Shane R, Rodman, Samuel N, Fath, Melissa A, Taylor, Eric B, Spitz, Douglas R

“…To determine if mitochondrial pyruvate transport could represent a therapeutic target for sensitizing cancer cells to oxidative stress, lung and breast cancer…”
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How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies by Piccirillo, Sarah, McCune, Abbigail H, Dedert, Samuel R, Kempf, Cassandra G, Jimenez, Brian, Solst, Shane R, Tiede-Lewis, LeAnn M, Honigberg, Saul M

“…How do boundaries between cells of different types form? Such boundaries are critical for metazoan development, but even in microorganisms, boundaries between…”
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How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies by Piccirillo, Sarah, McCune, Abbigail H, Dedert, Samuel R, Kempf, Cassandra G, Jimenez, Brian, Solst, Shane R, Tiede-Lewis, LeAnn M, Honigberg, Saul M

“…How do boundaries between cells of different types form? Such boundaries are critical for metazoan development, but even in microorganisms, boundaries between…”
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