Search Results - "Solski, Patricia A"

ROCK-Generated Contractility Regulates Breast Epithelial Cell Differentiation in Response to the Physical Properties of a Three-Dimensional Collagen Matrix by Wozniak, Michele A., Desai, Radhika, Solski, Patricia A., Der, Channing J., Keely, Patricia J.

“…Breast epithelial cells differentiate into tubules when cultured in floating three-dimensional (3D) collagen gels, but not when the cells are cultured in the…”
Get full text

Citron Kinase, a RhoA Effector, Enhances HIV‐1 Virion Production by Modulating Exocytosis by Loomis, Rebecca J., Holmes, Derek A., Elms, Andrew, Solski, Patricia A., Der, Channing J., Su, Lishan

“…RhoGTPases play important roles in the regulation of protein transport and membrane recycling. Little is known, however, about how RhoGTPases affect HIV‐1…”
Get full text

Requirement For C-terminal Sequences in Regulation of Ect2 Guanine Nucleotide Exchange Specificity and Transformation by Solski, Patricia A., Wilder, Rhonda S., Rossman, Kent L., Sondek, John, Cox, Adrienne D., Campbell, Sharon L., Der, Channing J.

“…Ect2 was identified originally as a transforming protein and a member of the Dbl family of Rho guanine nucleotide exchange factors (GEFs). Like all Dbl family…”
Get full text

Cellular functions of TC10, a rho family GTPase : regulation of morphology, signal transduction and cell growth by MURPHY, G. A, SOLSKI, P. A, JILLIAN, S. A, PEREZ DE LA OSSA, P, D'EUSTACHIO, P, DER, C. J, RUSH, M. G

“…The small Ras-related GTPase, TC10, has been classified on the basis of sequence homology to be a member of the Rho family. This family, which includes the…”
Get full text

Modulation of HIV-1 Replication by a Novel RhoA Effector Activity by Wang, Liping, Zhang, Hangchun, Solski, Patricia A, Hart, Matthew J, Der, Channing J, Su, Lishan

“…The RhoA GTPase is involved in regulating actin cytoskeletal organization, gene expression, cell proliferation, and survival. We report here that p115-RhoGEF,…”
Get full text

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation by Khosravi-Far, Roya, Solski, Patricia A., Clark, Geoffrey J., Kinch, Michael S., Der, Channing J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration by Cook, Danielle R, Solski, Patricia A, Bultman, Scott J, Kauselmann, Gunther, Schoor, Michael, Kuehn, Ralf, Friedman, Lori S, Cowley, Dale O, Van Dyke, Terry, Yeh, Jen Jen, Johnson, Leisa, Der, Channing J

“…Ect2 is a member of the human Dbl family of guanine nucleotide exchange factors (RhoGEFs) that serve as activators of Rho family small GTPases. Although Ect2…”
Get full text

The Mitogen-activated Protein Kinase Phosphatases PAC1, MKP-1, and MKP-2 Have Unique Substrate Specificities and Reduced Activity in Vivo toward the ERK2 sevenmaker Mutation by Chu, Y, Solski, P A, Khosravi-Far, R, Der, C J, Kelly, K

“…Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to carry out unique functions…”
Get full text

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation by Khosravi-Far, Roya, White, Michael A., Westwick, John K., Solski, Patricia A., Chrzanowska-Wodnicka, Magdalena, Van Aelst, Linda, Wigler, Michael H., Der, Channing J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A Non-farnesylated Ha-Ras Protein Can Be Palmitoylated and Trigger Potent Differentiation and Transformation by Booden, M A, Baker, T L, Solski, P A, Der, C J, Punke, S G, Buss, J E

“…Ha-Ras undergoes post-translational modifications (including attachment of farnesyl and palmitate) that culminate in localization of the protein to the plasma…”
Get full text

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal by Buss, Janice E., Solski, Patricia A., Schaeffer, James P., MacDonald, Marsha J., Der, Channing J.

“…The 21-kD proteins encoded by ras oncogenes (p21Ras) are modified covalently by a palmitate attached to a cysteine residue near the carboxyl terminus. Changing…”
Get full text

RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification by SOLSKI, Patricia A, HELMS, Whitney, KEELY, Patricia J, LISHAN SU, DER, Channing J

“…Recent studies showed that specific isoprenoid modification may be critical for RhoB subcellular location and function. Therefore, we determined whether the…”
Get full text

Critical role of Rho in cell transformation by oncogenic Ras by Prendergast, G C, Khosravi-Far, R, Solski, P A, Kurzawa, H, Lebowitz, P F, Der, C J

“…We demonstrate that Rho, a regulator of cytoskeletal actin, is necessary for Ras transformation. A dominant inhibitory Rho gene (RhoBN19) specifically…”
Get more information

P21ras is Modified by a Farnesyl Isoprenoid by Casey, Patrick J., Solski, Patricia A., Der, Channing J., Buss, Janice E.

“…Association of oncogenic ras proteins with cellular membranes appears to be a crucial step in transformation. ras is synthesized as a cytosolic precursor,…”
Get full text

Oncogenic Neu/ErbB-2 increases Ets, AP-1, and NF- Kappa B-dependent gene expression, and inhibiting Ets activation blocks Neu-mediated cellular transformation by Galang, C K, Garcia-Ramirez, J J, Solski, P A, Westwick, J K, Der, C J, Neznanov, N N, Oshima, R G, Hauser, CA

“…Overexpression of Neu (ErbB-2/HER2) is found in similar to 20% of breast tumors. Activation of Neu by a point mutation (Neu sub(T)) causes constitutive…”
Get full text

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras by Khosravi-Far, R, Chrzanowska-Wodnicka, M, Solski, P A, Eva, A, Burridge, K, Der, C J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Novel determinants of H-Ras plasma membrane localization and transformation by Willumsen, B M, Cox, A D, Solski, P A, Der, C J, Buss, J E

“…Although it is well-established that modification of Ras by farnesol is a critical step for its membrane association and transforming activity, the…”
Get more information

Farnesol Modification of Kirsten-Ras Exon 4B Protein is Essential for Transformation by Jackson, Janis H., Cochrane, Charles G., Bourne, Jeffrey R., Solski, Patricia A., Buss, Janice E., Der, Channing J.

“…Oncogenic forms of ras proteins are synthesized in the cytosol and must become membrane associated to cause malignant transformation. Palmitic acid and an…”
Get full text

Modulation of HIV-1 Replication by a Novel RhoA Effector Activity1 by Wang, Liping, Zhang, Hangchun, Solski, Patricia A., Hart, Matthew J., Der, Channing J., Su, Lishan

“…The RhoA GTPase is involved in regulating actin cytoskeletal organization, gene expression, cell proliferation, and survival. We report here that p115-RhoGEF,…”
Get full text

Analyses of transforming activity of Rho family activators by Solski, P A, Abe, K, Der, C J

Get more information