Search Results - "Solowska, Joanna"

Hereditary spastic paraplegia SPG4: what is known and not known about the disease by Solowska, Joanna M, Baas, Peter W

“…Mutations in more than 70 distinct loci and more than 50 mutated gene products have been identified in patients with hereditary spastic paraplegias, a diverse…”
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Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin by Solowska, Joanna M, Rao, Anand N, Baas, Peter W

“…The gene, which produces two isoforms (M1 and M87) of the microtubule-severing protein spastin, is the chief gene mutated in hereditary spastic paraplegia…”
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The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches by Yu, Wenqian, Qiang, Liang, Solowska, Joanna M, Karabay, Arzu, Korulu, Sirin, Baas, Peter W

“…Neurons express two different microtubule-severing proteins, namely P60-katanin and spastin. Here, we performed studies on cultured neurons to ascertain…”
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Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules by Qiang, Liang, Yu, Wenqian, Liu, Mei, Solowska, Joanna M, Baas, Peter W

“…The formation of interstitial axonal branches involves the severing of microtubules at sites where new branches form. Here we wished to ascertain whether basic…”
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Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics by Solowska, Joanna M, D'Rozario, Mitchell, Jean, Daphney C, Davidson, Michael W, Marenda, Daniel R, Baas, Peter W

“…Mutations to the SPG4 gene encoding the microtubule-severing protein spastin are the most common cause of hereditary spastic paraplegia. Haploinsufficiency,…”
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Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia by Solowska, Joanna M, Morfini, Gerardo, Falnikar, Aditi, Himes, B. Timothy, Brady, Scott T, Huang, Dongyang, Baas, Peter W

“…Spastin and P60-katanin are two distinct microtubule-severing proteins. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most…”
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Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia by Solowska, Joanna M., Garbern, James Y., Baas, Peter W.

“…The spectrum of mutations (missense, non-sense and splice-site) associated with hereditary spastic paraplegia 4 (HSP-SPG4) (SPG4:OMIM#182601) has suggested…”
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Axonal Growth Is Sensitive to the Levels of Katanin, a Protein That Severs Microtubules by Karabay, Arzu, Yu, Wenqian, Solowska, Joanna M, Baird, Douglas H, Baas, Peter W

“…Katanin is a heterodimeric enzyme that severs microtubules from the centrosome so that they can move into the axon. Katanin is broadly distributed in the…”
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Regulation of Microtubule Severing by Katanin Subunits during Neuronal Development by Yu, Wenqian, Solowska, Joanna M, Qiang, Liang, Karabay, Arzu, Baird, Douglas, Baas, Peter W

“…Katanin, the microtubule-severing protein, consists of a subunit termed P60 that breaks the lattice of the microtubule and another subunit termed P80, the…”
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Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation by Dráberová, Eduarda, Vinopal, Stanislav, Morfini, Gerardo, Liu, Pei S, Sládková, Vladimíra, Sulimenko, Tetyana, Burns, Matthew R, Solowska, Joanna, Kulandaivel, Kandan, de Chadarévian, Jean-Pierre, Legido, Agustin, Mörk, Sverre J, Janáček, Jiří, Baas, Peter W, Dráber, Pavel, Katsetos, Christos D

“…We studied the expression and distribution of the microtubule-severing enzyme spastin in 3 human glioblastoma cell lines (U87MG, U138MG, and T98G) and in…”
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Collapsin-1/Semaphorin-III/D Is Regulated Developmentally in Purkinje Cells and Collapses Pontocerebellar Mossy Fiber Neuronal Growth Cones by Rabacchi, Sylvia A, Solowska, Joanna M, Kruk, Barbara, Luo, Yuling, Raper, Jonathan A, Baird, Douglas H

“…Most axons in the CNS innervate specific subregions or layers of their target regions and form contacts with specific types of target neurons, but the…”
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Pontocerebellar Axon Guidance: Neuropilin-1- and Semaphorin 3A-Sensitivity Gradients across Basilar Pontine Nuclei and Semaphorin 3A Variation across Cerebellum by Solowska, Joanna M., Mazurek, Agnieszka, Weinberger, Lauren, Baird, Douglas H.

“…To assess the role of semaphorin 3A (Sema3A) and its receptor component neuropilin-1 (Npn-1) in pontocerebellar axon guidance, we compared the distributions of…”
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Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development by Buster, Daniel W, Baird, Douglas H, Yu, Wenqian, Solowska, Joanna M, Chauvière, Muriel, Mazurek, Agnieszka, Kress, Michel, Baas, Peter W

“…Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules. We have obtained rodent sequences of…”
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Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats by Himes, B. Timothy, Liu, Yi, Solowska, Joanna M., Snyder, Evan Y., Fischer, Itzhak, Tessler, Alan

“…To test the idea that genetically engineered cells can rescue axotomized neurons, we transplanted fibroblasts and immortalized neural stem cells (NSCs)…”
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Expression of Normal and Mutant Avian Integrin Subunits in Rodent Cells by Solowska, Joanna, Guan, Jun-Lin, Marcantonio, Eugene E., Trevithick, Jane E., Buck, Clayton A., Hynes, Richard O.

“…We describe the expression of the β 1 subunit of avian integrin in rodent cells with the purpose of examining the structure-function relationships of various…”
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Expression of the mitotic kinesin Kif15 in postmitotic neurons: Implications for neuronal migration and development by Buster, Daniel W, Baird, Douglas H, Yu, Wenqian, Solowska, Joanna M

“…Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules. We have obtained rodent sequences of…”
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Cytoplasmic and transmembrane domains of integrin β1 and β3 subunits are functionally interchangeable by SOLOWSKA, J, EDELMAN, J. M, ALBELDA, S. M, BUCK, C. A

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Cytoplasmic and Transmembrane Domains of Integrin β 1 and β 3 Subunits Are Functionally Interchangeable by Solowska, Joanna, Edelman, Jonathan M., Albelda, Steven M., Buck, Clayton A.

“…Integrin β subunits combine with specific sets of α subunits to form functional adhesion receptors. The structure and binding properties of integrins suggest…”
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Immunohistochemical and molecular analysis of beta 1 and beta 3 integrins by Buck, C, Albelda, S, Damjanovich, L, Edelman, J, Shih, D T, Solowska, J

“…The expression and function of integrin subunits was examined by immunohistochemical staining of normal and malignant tissues and by producing specific changes…”
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