Search Results - "Soloviev, Maxim V"

Variations in hemodynamic parameters and ECG in healthy, conscious, freely moving telemetrized beagle dogs by Soloviev, Maxim V, Hamlin, Robert L, Shellhammer, Laurie J, Barrett, Randy M, Wally, Robert A, Birchmeier, Paul A, Schaefer, Gerald J

“…Interpretation of the dynamic cardiovascular parameters on safety pharmacology studies is a challenging process; sometimes, it is difficult to separate normal…”
Get full text

Different species require different correction factors for the QT interval by Soloviev, Maxim V, Hamlin, Robert L, Barrett, Randy M, Chengelis, Christopher P, Schaefer, Gerald J

“…The ICH S7B guideline specifically requests the evaluation of the QT interval in in vivo models as an accepted risk factor for fatal tachyarrythmias. While it…”
Get full text

Blood Compatibility of a Newly Developed Trileaflet Mechanical Heart Valve by Sato, Manabu, Harasaki, Hiroaki, Wika, Kent E, Soloviev, Maxim V, Lee, Andrew S

“…An ideal heart valve prosthesis, which has both the flow dynamic properties and blood compatibility of a tissue valve prosthesis and the durability of a…”
Get full text

Different Species Require Different Correction Factors For The QT Interval by Soloviev, Maxim V., Hamlin, Robert L., Barrett, Randy M., Chengelis, Christopher P., Schaefer, Gerald J.

Get full text

The Diplomate of the Safety Pharmacology Society (DSPS) certification exam by Redfern, Will S., Soloviev, Maxim V., Authier, Simon, Board of Directors

Get full text

Tracing Hepatic Gluconeogenesis Relative to Citric Acid Cycle Activity in Vitro and in Vivo by Beylot, Michel, Soloviev, Maxim V., David, France, Landau, Bernard R., Brunengraber, Henri

“…The validity of the use of a carbon tracer for investigating liver intermediary metabolism in vivo requires that the labeling pattern of liver metabolites not…”
Get full text

Limitations of the Mass Isotopomer Distribution Analysis of Glucose to Study Gluconeogenesis by Previs, Stephen F., Fernandez, Charles A., Yang, Dawei, Soloviev, Maxim V., David, France, Brunengraber, Henri

“…Mass isotopomer distribution analysis allows studying the synthesis of polymeric biomolecules from 15N, 13C-, or 2H-labeled monomeric units in the presence of…”
Get full text

CARDIOVASCULAR AND PHARMACOKINETIC ASSESSMENT OF MORPHINE IN CONSCIOUS RADIOTELEMETRY-IMPLANTED BEAGLE DOGS by Soloviev, Maxim V., Shellhammer, Laurie J., Landis, Kasey L., Freshwater, Les, Shuey, Dana L.

Get full text

Whole Blood Platelet Aggregation in Humans and Animals: A Comparative Study by Soloviev, Maxim V., Okazaki, Yukio, Harasaki, Hiroaki

“…Background.Many animal species are used to evaluate the performance and blood compatibility of cardiovascular devices, but interspecies differences in platelet…”
Get full text

COMPARISON OF TWO MAJOR IN VIVO CARDIOVASCULAR SAFETY PHARMACOLOGY MODELS by Soloviev, Maxim V., Barrett, Randy M., Birchmeier, Paul A., Shellhammer, Laurie J., Landis, Kasey L., Wally, Robert A., Chengelis, Christopher P.

Get full text

CONCURRENT CARDIOVASCULAR AND RESPIRATORY EVALUATION IN CONSCIOUS CYNOMOLGUS MONKEYS by Soloviev, Maxim V., Derchak, Alex, Setser, John J., Steinbacher, Elizabeth A., Klemm, Jessica L., Gumpf, Dave S., Shellhammer, Laurie J., Kearney, Ken R., Wilson, Ronald E.

Get full text

NORMAL VARIATIONS IN HEMODYNAMIC PARAMETERS AND ECG IN CONSCIOUS FREELY MOVING TELEMETERIZED CYNOMOLGUS MONKEYS by Soloviev, Maxim V., Barrett, Randy M., Wally, Robert A., Shellhammer, Laurie J., Landis, Kasey L., Steinbacher, Elizabeth A., Klemm, Jessica L., Gumpf, Dave S., Setser, John J.

Get full text

Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver by Previs, S F, Fernandez, C A, Yang, D, Soloviev, M V, David, F, Brunengraber, H

“…Mass isotopomer distribution analysis allows studying the synthesis of polymeric biomolecules from 15N, 13C-, or 2H-labeled monomeric units in the presence of…”
Get full text

Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo. Comparisons in the use of [3-13C]lactate, [2-13C]acetate, and alpha-keto[3-13C]isocaproate by Beylot, M, Soloviev, M V, David, F, Landau, B R, Brunengraber, H

“…The validity of the use of a carbon tracer for investigating liver intermediary metabolism in vivo requires that the labeling pattern of liver metabolites not…”
Get full text

Contributions of liver and kidneys to glycerol production and utilization in the dog by Previs, S.F. (Case Western Reserve University, Cleveland, OH.), Martin, S.K, Hazey, J.W, Soloviev, M.V, Keating, A.P, Lucas, D, David, F, Koshy, J, Kirschenbaum, D.W, Tserng, K.Y, Brunengraber, H

“…The classical concept holds that liver and kidneys are the main sinks of glycerol released by adipose tissue. However, rates of glycerol appearance (Ra) exceed…”
Get full text

Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry by Yang, D, Beylot, M, Agarwal, K C, Soloviev, M V, Brunengraber, H

“…Phenylacetate, derived from phenylalanine, is converted in human and primate liver to phenylacetylglutamine. The latter has been used to assess the labeling…”
Get more information

R,S-1,3-butanediol acetoacetate esters, potential alternates to lipid emulsions for total parenteral nutrition by Desrochers, Sylvain, Quinze, Khadijah, Dugas, Hermann, Dubreuil, Pascal, Bomont, Catherine, David, France, Agarwal, Kamlesh C., Kumar, Alok, Soloviev, Maxim V., Powers, Lisa, Landau, Bernard R., Brunengraber, Henri

“…We present the preparation and characterization of totally and partially water-soluble forms of fat which could replace emulsions of long-chain…”
Get full text

Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver by YING ZHANG, AGARWAL, K. C, BELOT, M, SOLOVIEV, M. V, DAVID, F, REIDER, M. W, ANDERSON, V. E, KOU-YI TSERNG, BRUENGRABER, H

“…The labeling of liver extra-mitochondrial acetyl-CoA was investigated in isolated rat livers perfused with [2-(13)C]acetate, [1-(13)C]octanoate, or…”
Get full text

Assay of the enantiomers of 1,2-propanediol, 1,3-butanediol, 1,3-pentanediol, and the corresponding hydroxyacids by gas chromatography-mass spectrometry by Powers, L, Ciraolo, S T, Agarwal, K C, Kumar, A, Bomont, C, Soloviev, M V, David, F, Desrochers, S, Brunengraber, H

“…We developed gas chromatographic-mass spectrometric assays for the enantiomers of 1,2-propanediol, 1,3-butanediol, 1,3-pentanediol, and their corresponding…”
Get more information

Use of [6,6-2H2]glucose and of low-enrichment [U-13C6]-glucose for sequential or simultaneous measurements of glucose turnover by gas chromatography-mass spectrometry by Previs, S F, Ciraolo, S T, Fernandez, C A, Beylot, M, Agarwal, K C, Soloviev, M V, Brunengraber, H

“…We developed gas chromatography-mass spectrometric methods for assaying the enrichment of 99 at.% [6,6-2H2]glucose and 30 at.% [U-13C6]glucose, although both…”
Get more information