Search Results - "Solomon, Lauren A"

Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism by MacLean Scott, Emily, Solomon, Lauren A, Davidson, Courtney, Storie, Jessica, Palikhe, Nami Shrestha, Cameron, Lisa

“…CRTh2 (encoded by PTGDR2) is a G-protein coupled receptor expressed by Th2 cells as well as eosinophils, basophils and innate lymphoid cells (ILC)2s…”
Get full text

PU.1 Regulates Ig Light Chain Transcription and Rearrangement in Pre-B Cells during B Cell Development by Batista, Carolina R, Li, Stephen K H, Xu, Li S, Solomon, Lauren A, DeKoter, Rodney P

“…B cell development and Ig rearrangement are governed by cell type- and developmental stage-specific transcription factors. PU.1 and Spi-B are…”
Get full text

Comparative efficacy of glucocorticoid receptor agonists on Th2 cell function and attenuation by progesterone by Luchak, Alexander, Solomon, Lauren A, Kanagalingam, Tharsan, Vijeyakumaran, Meerah, Rowe, Brian H, Cameron, Lisa

“…Abstract Background Corticosteroids (CS)s suppress cytokine production and induce apoptosis of inflammatory cells. Prednisone and dexamethasone are oral CSs…”
Get full text

Genome-wide comparison of PU.1 and Spi-B binding sites in a mouse B lymphoma cell line by Solomon, Lauren A, Li, Stephen K H, Piskorz, Jan, Xu, Li S, DeKoter, Rodney P

“…Spi-B and PU.1 are highly related members of the E26-transformation-specific (ETS) family of transcription factors that have similar, but not identical, roles…”
Get full text

Identification of a negative regulatory role for spi-C in the murine B cell lineage by Li, Stephen K H, Solomon, Lauren A, Fulkerson, Patricia C, DeKoter, Rodney P

“…Spi-C is an E26 transformation-specific family transcription factor that is highly related to PU.1 and Spi-B. Spi-C is expressed in developing B cells, but its…”
Get full text

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span by Watson, L. Ashley, Solomon, Lauren A, Li, Jennifer Ruizhe, Jiang, Yan, Edwards, Matthew, Shin-ya, Kazuo, Beier, Frank, Berube, Nathalie G

Get full text

Loss of ATRX in chondrocytes has minimal effects on skeletal development by Solomon, Lauren A, Li, Jennifer R, Bérubé, Nathalie G, Beier, Frank

“…Mutations in the human ATRX gene cause developmental defects, including skeletal deformities and dwarfism. ATRX encodes a chromatin remodeling protein, however…”
Get full text

Loss of ATRX does not confer susceptibility to osteoarthritis by Solomon, Lauren A, Russell, Bailey A, Makar, David, Bérubé, Nathalie G, Beier, Frank

“…The chromatin remodelling protein ATRX is associated with the rare genetic disorder ATR-X syndrome. This syndrome includes developmental delay, cognitive…”
Get full text

Transcriptional regulators of chondrocyte hypertrophy by Solomon, Lauren A., Bérubé, Nathalie G., Beier, Frank

“…Coordinated transition from proliferation to terminal differentiation and hypertrophy of growth plate chondrocytes is required for normal growth of…”
Get full text

A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation by Rhee, Jess, Solomon, Lauren A., DeKoter, Rodney P.

“…Differentiation of myeloid progenitor cells into macrophages is accompanied by increased PU.1 concentration and increasing cell cycle length, culminating in…”
Get full text

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span by Watson, L Ashley, Solomon, Lauren A, Li, Jennifer Ruizhe, Jiang, Yan, Edwards, Matthew, Shin-ya, Kazuo, Beier, Frank, Bérubé, Nathalie G

“…Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. We show that the Atrx-null embryonic mouse brain…”
Get full text

Lenalidomide modulates gene expression in human ABC-DLBCL cells by regulating IKAROS interaction with an intronic control region of SPIB by Solomon, Lauren A., Batista, Carolina R., DeKoter, Rodney P.

“…•Lenalidomide's mechanism of action in activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is not understood.•SPIB is transcriptionally downregulated by…”
Get full text

Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism by Solomon, Lauren A., Podder, Shreya, He, Jessica, Jackson-Chornenki, Nicholas L., Gibson, Kristen, Ziliotto, Rachel G., Rhee, Jess, DeKoter, Rodney P.

“…During macrophage development, myeloid progenitor cells undergo terminal differentiation coordinated with reduced cell cycle progression. Differentiation of…”
Get full text

The effect of maternal protein restriction during perinatal life on the inflammatory response in pediatric rats by Veldhuizen, Ruud A W, Baer, Brandon, McCaig, Lynda A, Solomon, Lauren A, Cameron, Lisa, Hardy, Daniel B

“…Fetal growth restriction can affect health outcomes in postnatal life. This study tested the hypothesis that the response to an inflammatory pulmonary insult…”
Get more information

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly by Solomon, Lauren A, Russell, Bailey A, Watson, L Ashley, Beier, Frank, Bérubé, Nathalie G

“…ATR-X syndrome is a rare genetic disorder caused by mutations in the ATRX gene. Affected individuals are cognitively impaired and display a variety of…”
Get full text

PU.1 opposes IL-7-dependent proliferation of developing B cells with involvement of the direct target gene bruton tyrosine kinase by Christie, Darah A, Xu, Li S, Turkistany, Shereen A, Solomon, Lauren A, Li, Stephen K H, Yim, Edmund, Welch, Ian, Bell, Gillian I, Hess, David A, DeKoter, Rodney P

“…Deletion of genes encoding the E26 transformation-specific transcription factors PU.1 and Spi-B in B cells (CD19-CreΔPB mice) leads to impaired B cell…”
Get full text

Nfkb1 Activation by the E26 Transformation-Specific Transcription Factors PU.1 and Spi-B Promotes Toll-Like Receptor-Mediated Splenic B Cell Proliferation by Li, Stephen K. H., Abbas, Ali K., Solomon, Lauren A., Groux, Gaëlle M. N., DeKoter, Rodney P.

“…Generation of antibodies against T-independent and T-dependent antigens requires Toll-like receptor (TLR) engagement on B cells for efficient responses…”
Get full text

Abstract 2098: Genome-wide comparison of PU.1 and Spi-B binding sites in a mouse B lymphoma cell line by Solomon, Lauren A., Li, Stephen K.h., Piskorz, Jan, Xu, Li S., DeKoter, Rodney P.

“…Abstract Background. The E26-transformation-specific (ETS) transcription factor Spi-B is required for the survival of Activated B Cell-type Diffuse Large B…”
Get full text

The Chromatin Remodeling Protein ATRX in Development and Maintenance of Mouse Skeletal Tissues by Solomon, Lauren A

“…Alpha-thalassemia X-linked mental retardation (ATR-X) syndrome is a rare genetic disorder associated with severe developmental delay, mental retardation and…”
Get full text