New approaches in correcting disorders of higher integrative brain functions in the pharmacotherapy of arterial hypertension with propranolol

In experiments on rats it is found that propranolol in a dose of 2 mg/kg has a negative effect on higher integrative functions of the brain. Nootropics--pyracetam (200 mg/kg), AKF-94 (20 mg/kg), PIR-87-6-O (50 mg/kg) and actoprotector bemityl (40 mg/kg)--normalized orientative-trying behavior, memor...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 61; no. 5; p. 10
Main Authors:	Petrov, V I, Solomin, M Iu, Gorbunov, S G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1998
Subjects:	Animals Antihypertensive Agents - therapeutic use Behavior, Animal - drug effects Brain - drug effects Conditioning, Classical - drug effects Drug Evaluation, Preclinical Drug Therapy, Combination Higher Nervous Activity - drug effects Hypertension - drug therapy Male Nootropic Agents - therapeutic use Propranolol - therapeutic use Rats
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Summary:	In experiments on rats it is found that propranolol in a dose of 2 mg/kg has a negative effect on higher integrative functions of the brain. Nootropics--pyracetam (200 mg/kg), AKF-94 (20 mg/kg), PIR-87-6-O (50 mg/kg) and actoprotector bemityl (40 mg/kg)--normalized orientative-trying behavior, memory, and emotionality of the animals. A possible mechanism of the drug action and prospects of their clinical application are discussed.
ISSN:	0869-2092