Search Results - "Soloff, Adam C."

Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy by Williams, Carly Bess, Yeh, Elizabeth S, Soloff, Adam C

“…Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence demonstrates that macrophages, the most abundant leukocyte population in…”
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Targeting the ERβ/HER Oncogenic Network in KRAS Mutant Lung Cancer Modulates the Tumor Microenvironment and Is Synergistic with Sequential Immunotherapy by Almotlak, Abdulaziz A, Farooqui, Mariya, Soloff, Adam C, Siegfried, Jill M, Stabile, Laura P

“…High ERβ/HER oncogenic signaling defines lung tumors with an aggressive biology. We previously showed that combining the anti-estrogen fulvestrant with the…”
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Making cold malignant pleural effusions hot: driving novel immunotherapies by Murthy, Pranav, Ekeke, Chigozirim N., Russell, Kira L., Butler, Samuel C., Wang, Yue, Luketich, James D., Soloff, Adam C., Dhupar, Rajeev, Lotze, Michael T.

“…Malignant pleural effusions, arising from either primary mesotheliomas or secondary malignancies, heralds advanced disease and poor prognosis. Current…”
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HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer by Ramos Solis, Nicole, Cannon, Anthony, Dilday, Tinslee, Abt, Melissa, Oblak, Adrian L, Soloff, Adam C, Kaplan, Mark H, Yeh, Elizabeth S

“…Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2…”
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Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors by Zhu, Li, Narloch, Jessica L., Onkar, Sayali, Joy, Marion, Broadwater, Gloria, Luedke, Catherine, Hall, Allison, Kim, Rim, Pogue-Geile, Katherine, Sammons, Sarah, Nayyar, Naema, Chukwueke, Ugonma, Brastianos, Priscilla K., Anders, Carey K., Soloff, Adam C., Vignali, Dario A. A., Tseng, George C., Emens, Leisha A., Lucas, Peter C., Blackwell, Kimberly L., Oesterreich, Steffi, Lee, Adrian V.

“…The interplay between the immune system and tumor progression is well recognized. However, current human breast cancer immunophenotyping studies are mostly…”
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Enemy at the gates： dendritic cells and immunity to mucosal pathogens by Soloff, Adam C, Barratt-boyes, Simon M

“…Dendritic cells （DC） are diverse and specialized hematopoietic cells serving as an essential bridge between innate and adaptive immunity. DC exist in all…”
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Characteristics of Malignant Pleural Effusion Resident CD8 + T Cells from a Heterogeneous Collection of Tumors by Dhupar, Rajeev, Okusanya, Olugbenga T, Eisenberg, Seth H, Monaco, Sara E, Ruffin, Ayana T, Liu, Dongyan, Luketich, James D, Kammula, Udai S, Bruno, Tullia C, Lotze, Michael T, Soloff, Adam C

“…While T cell-based cancer immunotherapies have shown great promise, there remains a need to understand how individual metastatic tumor environments impart…”
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Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer by Bauman, Julie E, Ohr, James, Gooding, William E, Ferris, Robert L, Duvvuri, Umamaheswar, Kim, Seungwon, Johnson, Jonas T, Soloff, Adam C, Wallweber, Gerald, Winslow, John, Gaither-Davis, Autumn, Grandis, Jennifer R, Stabile, Laura P

“…Cetuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and neck squamous cell carcinoma (HNSCC) but benefits a minority. An…”
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Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization by WENTAO GAO, SOLOFF, Adam C, BARRATT-BOYES, Simon M, GAMBOTTO, Andrea, XIUHUA LU, MONTECALVO, Angela, NGUYEN, Doan C, MATSUOKA, Yumi, ROBBINS, Paul D, SWAYNE, David E, DONIS, Ruben O, KATZ, Jacqueline M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer by Dhupar, Rajeev, Jones, Katherine E, Powers, Amy A, Eisenberg, Seth H, Ding, Kai, Chen, Fangyuan, Nasarre, Cecile, Cen, Zhanpeng, Gong, Yi-Nan, LaRue, Amanda C, Yeh, Elizabeth S, Luketich, James D, Lee, Adrian V, Oesterreich, Steffi, Lotze, Michael T, Gemmill, Robert M, Soloff, Adam C

“…Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis…”
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Hematopoietic Stem Cell–Derived Cancer–Associated Fibroblasts Are Novel Contributors to the Pro-Tumorigenic Microenvironment by McDonald, Lindsay T, Russell, Dayvia L, Kelly, Ryan R, Xiong, Ying, Motamarry, Anjan, Patel, Risha K, Jones, Jeffrey A, Watson, Patricia M, Turner, David P, Watson, Dennis K, Soloff, Adam C, Findlay, Victoria J, LaRue, Amanda C

“…Abstract Targeting the tumor microenvironment is critical toward improving the effectiveness of cancer therapeutics. Cancer-associated fibroblasts (CAFs) are…”
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A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients by Lilly, Michael B., Wu, Chunli, Ke, Yu, Chen, Wen‐Pin, Soloff, Adam C., Armeson, Kent, Yokoyama, Noriko N., Li, Xiaotian, Song, Liankun, Yuan, Ying, McLaren, Christine E., Zi, Xiaolin

“…Purpose Our preclinical studies showed that lycopene enhanced the anti‐prostate cancer efficacy of docetaxel in animal models. A phase I trial (NCT0149519) was…”
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HMGB1 Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions by Soloff, Adam C, Jones, Katherine E, Powers, Amy A, Murthy, Pranav, Wang, Yue, Russell, Kira L, Byrne-Steele, Miranda, Lund, Amanda W, Yuan, Jian-Min, Monaco, Sara E, Han, Jian, Dhupar, Rajeev, Lotze, Michael T

“…Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by…”
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Massive Mobilization of Dendritic Cells During Influenza A Virus Subtype H5N1 Infection of Nonhuman Primates by Soloff, Adam C., Bissel, Stephanie J., Junecko, Beth Fallert, Giles, Brendan M., Reinhart, Todd A., Ross, Ted M., Barratt-Boyes, Simon M.

“…Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is…”
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Early myeloid dendritic cell dysregulation is predictive of disease progression in simian immunodeficiency virus infection by Wijewardana, Viskam, Soloff, Adam C, Liu, Xiangdong, Brown, Kevin N, Barratt-Boyes, Simon M

“…Myeloid dendritic cells (mDC) are lost from blood in individuals with human immunodeficiency virus (HIV) infection but the mechanism for this loss and its…”
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A peaceful death orchestrates immune balance in a chaotic environment by Soloff, Adam C., Lotze, Michael T.

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Intrapleural interleukin-2–expressing oncolytic virotherapy enhances acute antitumor effects and T-cell receptor diversity in malignant pleural disease by Ekeke, Chigozirim N., Russell, Kira L., Murthy, Pranav, Guo, Zong Sheng, Soloff, Adam C., Weber, Daniel, Pan, Wenjing, Lotze, Michael T., Dhupar, Rajeev

“…The mainstay of treatment for patients with malignant pleural disease is fluid drainage and systemic therapy. A tumor-specific oncolytic virus or…”
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Fighting Fire With Fire: Oncolytic Virotherapy for Thoracic Malignancies by Ekeke, Chigozirim N., Russell, Kira L., Joubert, Kyla, Bartlett, David L., Luketich, James D., Soloff, Adam C., Guo, Zong Sheng, Lotze, Michael T., Dhupar, Rajeev

“…Thoracic malignancies are associated with high mortality rates. Conventional therapy for many of the patients with thoracic malignancies is obviated by a high…”
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Environmental perfluorooctane sulfonate exposure drives T cell activation in bottlenose dolphins by Soloff, Adam C., Wolf, Bethany Jacobs, White, Natasha D., Muir, Derek, Courtney, Sean, Hardiman, Gary, Bossart, Gregory D., Fair, Patricia A.

“…Perfluoroalkyl acids (PFAAs) are highly stable compounds that have been associated with immunotoxicity in epidemiologic studies and experimental rodent models…”
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Experimental respiratory exposure to putative Gulf War toxins promotes persistent alveolar macrophage recruitment and pulmonary inflammation by Powers, Amy A., Jones, Katherine E., Eisenberg, Seth H., Rigatti, Lora H., Ryan, John P., Luketich, James D., Lotze, Michael T., LaRue, Amanda C., Dhupar, Rajeev, Soloff, Adam C.

“…Respiratory disorders are a prominent component of Gulf War Illness. Although much of the underlying mechanisms of Gulf War Illness remain undefined, chronic…”
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