Search Results - "Solis, Willy A"

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates by Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

“…Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen et al. show that the local chemical…”
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Role of the aromatic hydrocarbon receptor and [ Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis by Nebert, Daniel W, Roe, Amy L, Dieter, Matthew Z, Solis, Willy A, Yang, Yi, Dalton, Timothy P

“…The chronology and history of characterizing the aromatic hydrocarbon [ Ah] battery is reviewed. This battery represents the Ah receptor (AHR)-mediated control…”
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Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid by Ahn, Shin Hye, Vaughn, Brett A, Solis, Willy A, Lupher, Mark L, Hallam, Trevor J, Boros, Eszter

“…Antibody–drug conjugates (ADCs) are a class of targeted therapeutics consisting of a monoclonal antibody coupled to a cytotoxic payload. Various bioconjugation…”
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Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001 by Abrahams, Cristina L, Li, Xiaofan, Embry, Millicent, Yu, Abigail, Krimm, Stellanie, Krueger, Sarah, Greenland, Nancy Y, Wen, Kwun Wah, Jones, Chris, DeAlmeida, Venita, Solis, Willy A, Matheny, Shannon, Kline, Toni, Yam, Alice Y, Stafford, Ryan, Wiita, Arun P, Hallam, Trevor, Lupher, Mark, Molina, Arturo

“…STRO-001 is a site-specific, predominantly single-species, fully human, aglycosylated anti-CD74 antibody-drug conjugate incorporating a non-cleavable…”
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Site-Specific 89 Zr- and 111 In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide-Alkyne Cycloaddition with a Non-natural Amino Acid by Ahn, Shin Hye, Vaughn, Brett A, Solis, Willy A, Lupher, Jr, Mark L, Hallam, Trevor J, Boros, Eszter

“…Antibody-drug conjugates (ADCs) are a class of targeted therapeutics consisting of a monoclonal antibody coupled to a cytotoxic payload. Various bioconjugation…”
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Characterization of the MTF-1 transcription factor from zebrafish and trout cells by Dalton, Timothy P, Solis, Willy A, Nebert, Daniel W, Carvan III, Michael J

“…The metal response element (MRE)-binding transcription factor-1, MTF-1, is a zinc-responsive protein that controls transcription of metallothionein (MT) genes…”
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Glutamate–cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress by Solis, Willy A., Dalton, Timothy P., Dieter, Matthew Z., Freshwater, Sarah, Harrer, Judy M., He, Lei, Shertzer, Howard G., Nebert, Daniel W.

“…Glutamate–cysteine ligase is a heterodimer comprising a modifier (GCLM) and a catalytic (GCLC) subunit. In mouse Hepa-1c1c7 hepatoma cell cultures, we found…”
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Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins by Carvan, 3rd, MJ, Ponomareva, LV, Solis, WA, Matlib, RS, Puga, A, Nebert, DW

“…: Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of…”
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Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements by Dieter, Matthew Z, Freshwater, Sarah L, Solis, Willy A, Nebert, Daniel W, Dalton, Timothy P

“…To investigate a possible role of phosphorylation in the signal transduction pathways responsible for transcriptional regulation of drug-metabolizing enzymes,…”
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Use of Reporter Genes and Vertebrate DNA Motifs in Transgenic Zebrafish as Sentinels for Assessing Aquatic Pollution by Nebert, Daniel W., Stuart, Gary W., Solis, Willy A., Carvan, Michael J.

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Retrovirally Expressed Metal Response Element-Binding Transcription Factor-1 Normalizes Metallothionein-1 Gene Expression and Protects Cells against Zinc, but Not Cadmium, Toxicity by Solis, Willy A., Childs, Nicole L., Weedon, Michael N., He, Lei, Nebert, Daniel W., Dalton, Timothy P.

“…Metal response element (MRE) transcription factor-1 (MTF1), a member of the Cys2-His2 class of zinc-finger transcription factors, is best known for its robust…”
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Abstract 4502: Nonclinical characterization and tolerability of a surrogate anti-mesothelin-MMAE antibody-drug conjugate by Gupta, Nidhi, Solis, Willy A., Fuji, Reina N., Oldendorp, Amy, Pacheco, Glenn, Luis, Elizabeth, Chuh, Josefa, French, Dorothy M., Drake, Elizabeth, Dennis, Mark S., Kozak, Katherine R., Ross, Sarajane, Tibbitts, Jay, Spencer, Susan D., Scales, Suzie J.

“…Mesothelin (MSLN) is a cell surface glycoprotein widely expressed in several cancers with normal expression limited to the serosal mesothelia, features of an…”
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Activation of Transcription Factors in Zebrafish Cell Cultures by Environmental Pollutants by Carvan, Michael J., Solis, Willy A., Gedamu, Lashitew, Nebert, Daniel W.

“…Many classes of environmental pollutants are found at significant levels in the aquatic environment. We are designing a fish model as an inexpensive and…”
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Erratum to “Tyrphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements”: [Biochem. Pharmacol. 61 (2001) 215–225] by Dieter, Matthew Z, Freshwater, Sarah L, Solis, Willy A, Nebert, Daniel W, Dalton, Timothy P

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Tryphostin AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements11Abbreviations: EPRE, electrophile response element; AHRE, aromatic hydrocarbon response element; MRE, metal response element; Nqo1 and NQO1, mouse NAD(P)H:quinone oxidoreductase [also called NMO1, quinone reductase, DT-diaphorase] gene and mRNA; Cyp1a1 and CYP1A1, mouse cytochrome P450 1A1 gene and mRNA; Mt1 and MT1, mouse metallothionein-1 g by Dieter, Matthew Z, Freshwater, Sarah L, Solis, Willy A, Nebert, Daniel W, Dalton, Timothy P

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Mechanisms of glutamate-cysteine ligase modifier (Gclm) and metallothioenin-1 (Mt1) regulation by oxidative stress by Solis, Willy A

“…The first part of this dissertation focuses on the cellular antioxidant glutathione (GSH). In GSH de novo GSH synthesis, the first and rate-limiting step is…”
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Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress by SOLIS, Willy A, DALTON, Timothy P, DIETER, Matthew Z, FRESHWATER, Sarah, HARRER, Judy M, LEI HE, SHERTZER, Howard G, NEBERT, Daniel W

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Mechanisms of glutamate -cysteine ligase modifier (Gclm) and metallothionein-1 (Mt1) regulation by oxidative stress by Solis, Willy A

“…The first part of this dissertation focuses on the cellular antioxidant glutathione (GSH). In GSH de novo GSH synthesis, the first and rate-limiting step is…”
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