Search Results - "Solis, Norma V."
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Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence
Published in PLoS pathogens (01-01-2022)“…Candida albicans is a major opportunistic pathogen of humans. It can grow as morphologically distinct yeast, pseudohyphae and hyphae, and the ability to switch…”
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Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity
Published in Frontiers in immunology (22-10-2020)“…The fungus colonizes the oral mucosal surface of 30-70% of healthy individuals. Due to local or systemic immunosuppression, this commensal fungus is able to…”
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Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection
Published in The Journal of infectious diseases (01-11-2019)“…Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis…”
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Activation and alliance of regulatory pathways in C. albicans during mammalian infection
Published in PLoS biology (01-02-2015)“…Gene expression dynamics have provided foundational insight into almost all biological processes. Here, we analyze expression of environmentally responsive…”
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Candida albicans Oropharyngeal Infection Is an Exception to Iron-Based Nutritional Immunity
Published in mBio (25-04-2023)“…Candida albicans is a commensal of the human gastrointestinal tract and a common cause of human fungal disease, including mucosal infections, such as…”
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IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
Published in Nature communications (22-09-2022)“…During infection the host relies on pattern-recognition receptors to sense invading fungal pathogens to launch immune defense mechanisms. While fungal…”
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Functional Dichotomy for a Hyphal Repressor in Candida albicans
Published in mBio (25-04-2023)“…Nrg1 is a repressor of hypha formation and hypha-associated gene expression in the fungal pathogen Candida albicans. It has been well studied in the genetic…”
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EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection
Published in Proceedings of the National Academy of Sciences - PNAS (28-08-2012)“…The fungus Candida albicans is the major cause of oropharyngeal candidiasis (OPC). A key feature of this disease is fungal invasion of oral epithelial cells, a…”
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Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality
Published in PLoS genetics (21-01-2020)“…Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way…”
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Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans
Published in Nature communications (09-05-2024)“…Patients with decreased levels of CD18 (β2 integrins) suffer from life-threatening bacterial and fungal infections. CD11b, the α subunit of integrin CR3…”
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EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
Published in Cell reports (Cambridge) (09-07-2019)“…During oropharyngeal candidiasis (OPC), Candida albicans proliferates and invades the superficial oral epithelium. Ephrin type-A receptor 2 (EphA2) functions…”
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Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors
Published in PLoS pathogens (20-01-2021)“…During oropharyngeal candidiasis (OPC), Candida albicans invades and damages oral epithelial cells, which respond by producing proinflammatory mediators that…”
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Host cell invasion and virulence mediated by Candida albicans Ssa1
Published in PLoS pathogens (01-11-2010)“…Candida albicans Ssa1 and Ssa2 are members of the HSP70 family of heat shock proteins that are expressed on the cell surface and function as receptors for…”
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Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype
Published in PLoS genetics (15-05-2019)“…When the fungus Candida albicans proliferates in the oropharyngeal cavity during experimental oropharyngeal candidiasis (OPC), it undergoes large-scale genome…”
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Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection
Published in PLoS pathogens (23-08-2023)“…Fungal invasion of the oral epithelium is central to the pathogenesis of oropharyngeal candidiasis (OPC). Candida albicans invades the oral epithelium by…”
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The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis
Published in mBio (21-03-2017)“…Oropharyngeal candidiasis (OPC), caused predominantly by , is a prevalent infection in patients with advanced AIDS, defects in Th17 immunity, and head and neck…”
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Hgc1 Independence of Biofilm Hyphae in Candida albicans
Published in mBio (25-04-2023)“…Biofilm and hypha formation are central to virulence of the fungal pathogen Candida albicans. The G1 cyclin gene is required for hypha formation under diverse…”
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Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes
Published in PLoS pathogens (30-07-2024)“…Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of…”
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Role of Arf GTPases in fungal morphogenesis and virulence
Published in PLoS pathogens (01-02-2017)“…Virulence of the human fungal pathogen Candida albicans depends on the switch from budding to filamentous growth, which requires sustained membrane traffic and…”
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Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes
Published in PLoS genetics (11-06-2020)“…Iron is an essential nutrient required as a cofactor for many biological processes. As a fungal commensal-pathogen of humans, Candida albicans encounters a…”
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