Search Results - "Solinís, M.A."

Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles by Apaolaza, P.S, del Pozo-Rodríguez, A, Solinís, M.A, Rodríguez, J.M, Friedrich, U, Torrecilla, J, Weber, B.H.F, Rodríguez-Gascón, A

“…Abstract X-linked juvenile retinoschisis (XLRS) is a retinal degenerative disorder caused by mutations in the RS1 gene encoding a protein termed retinoschisin…”
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Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy by del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Most studies in gene therapy are focused on developing more efficient non-viral vectors, ignoring their stability, even though physically and chemically stable…”
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Solid lipid nanoparticle-based vectors intended for the treatment of X-linked juvenile retinoschisis by gene therapy: In vivo approaches in Rs1h-deficient mouse model by Apaolaza, P.S., del Pozo-Rodríguez, A., Torrecilla, J., Rodríguez-Gascón, A., Rodríguez, J.M., Friedrich, U., Weber, B.H.F., Solinís, M.A.

“…X-linked juvenile retinoschisis (XLRS), which results from mutations in the gene RS1 that encodes the protein retinoschisin, is a retinal degenerative disease…”
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Biodistribution of Nanostructured Lipid Carriers (NLCs) after intravenous administration to rats: Influence of technological factors by Beloqui, A., Solinís, M.A., Delgado, A., Évora, C., del Pozo-Rodríguez, A., Rodríguez-Gascón, A.

“…Nanostructured Lipid Carriers (NLCs) differing on particle size, surface charge, and surfactant content were radiolabeled with 99mTc and intravenously…”
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A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors by del Pozo-Rodríguez, A., Pujals, S., Delgado, D., Solinís, M.A., Gascón, A.R., Giralt, E., Pedraz, J.L.

“…The aim of this work was to improve the transfection efficacy of solid lipid nanoparticle (SLN)-based non-viral vectors into ARPE-19 cells through the addition…”
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Solid lipid nanoparticles for retinal gene therapy: Transfection and intracellular trafficking in RPE cells by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Retinal pigment epithelial (RPE) cells are usually employed to study DNA systems for diseases related to problems in the retina. Solid lipid nanoparticles…”
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Solid lipid nanoparticles: Formulation factors affecting cell transfection capacity by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Since solid lipid nanoparticles (SLNs) were introduced as non-viral transfection systems, very few reports of their use for gene delivery have been published…”
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Determination of ceftazidime and cefepime in plasma and dialysate-ultrafiltrate from patients undergoing continuous veno-venous hemodiafiltration by HPLC by Isla, A., Arzuaga, A., Maynar, J., Gascón, A.R., Solinís, M.A., Corral, E., Pedraz, J.L.

“…We have developed and validated a new, rapid and reproducible HPLC method for the determination of cefepime and ceftazidime in plasma and…”
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Bioequivalence of 2 oral ciprofloxacin tablets formulations by Cuadrado, A., Gascón, A.R., Solinís, M.A., Ramírez, E., Hernández, R.M., Knie, U., Pedraz, J.L.

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Hiccups in Parkinson’s disease: an analysis of cases reported in the European pharmacovigilance database and a review of the literature by Lertxundi, U., Marquínez, A.C, Domingo-Echaburu, S., Solinís, M.Á, Calvo, B., Del Pozo-Rodríguez, A., García, M., Aguirre, C., Isla, A.

“…Background Some reports have suggested an association between dopamine agonists and hiccups, involuntary contractions that merit full clinical attention…”
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Novel extended-release formulation of lovastatin by one-step melt granulation: In vitro and in vivo evaluation by Ochoa, L., Igartua, M., Hernández, R.M., Gascón, A.R., Solinis, M.A., Pedraz, J.L.

“…The novel extended-release formulation of lovastatin developed exhibits zero-order release in vitro and provides extended plasma levels of lovastatin and its…”
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Comparative bioavailability of two immediate-release tablets of lisinopril/hydrochlorothiazide in healthy volunteers by GASCON, A. R, CUADRADO, A, SOLINIS, M. A, HERNANDEZ, R. M, RAMIREZ, E, DALMAU, R, PEDRAZ, J. L

“…Two formulations of lisinopril/hydrochlorothiazide (20 mg/12.5 mg) were evaluated for bioequivalence after single dosing in healthy volunteers. The study was…”
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Release of ketoprofen enantiomers from HPMC K100M matrices—diffusion studies by Solinı́s, M.A., de la Cruz, Y., Hernández, R.M., Gascón, A.R., Calvo, B., Pedraz, J.L.

“…Sustained release formulations of ketoprofen elaborated with HPMC K100M were studied to test the hypothesis that chiral excipients can stereoselectively affect…”
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Release of salbutamol sulfate enantiomers from hydroxypropylmethylcellulose matrices by Solinı́s, M.A, Lugará, S, Calvo, B, Hernández, R.M, Gascón, A.R, Pedraz, J.L

“…The in vitro dissolution profiles of nine sustained-release formulations of (±)-salbutamol were determined. The formulations contained chiral pharmaceutical…”
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