Search Results - "Solimini, Nicole L"

Non-Oncogene Addiction and the Stress Phenotype of Cancer Cells by Solimini, Nicole L., Luo, Ji, Elledge, Stephen J.

“…Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this…”
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A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis by Kessler, Jessica D., Kahle, Kristopher T., Sun, Tingting, Meerbrey, Kristen L., Schlabach, Michael R., Schmitt, Earlene M., Skinner, Samuel O., Xu, Qikai, Li, Mamie Z., Hartman, Zachary C., Rao, Mitchell, Yu, Peng, Dominguez-Vidana, Rocio, Liang, Anthony C., Solimini, Nicole L., Bernardi, Ronald J., Yu, Bing, Hsu, Tiffany, Golding, Ido, Luo, Ji, Osborne, C. Kent, Creighton, Chad J., Hilsenbeck, Susan G., Schiff, Rachel, Shaw, Chad A., Elledge, Stephen J., Westbrook, Thomas F.

“…Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we used a…”
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Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential by Solimini, Nicole L., Xu, Qikai, Mermel, Craig H., Liang, Anthony C., Schlabach, Michael R., Luo, Ji, Burrows, Anna E., Anselmo, Anthony N., Bredemeyer, Andrea L., Li, Mamie Z., Beroukhim, Rameen, Meyerson, Matthew, Elledge, Stephen J.

“…Tumors exhibit numerous recurrent hemizygous focal deletions that contain no known tumor suppressors and are poorly understood. To investigate whether these…”
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Cancer Proliferation Gene Discovery Through Functional Genomics by Schlabach, Michael R, Luo, Ji, Solimini, Nicole L, Hu, Guang, Xu, Qikai, Li, Mamie Z, Zhao, Zhenming, Smogorzewska, Agata, Sowa, Mathew E, Ang, Xiaolu L, Westbrook, Thomas F, Liang, Anthony C, Chang, Kenneth, Hackett, Jennifer A, Harper, J. Wade, Hannon, Gregory J, Elledge, Stephen J

“…Retroviral short hairpin RNA (shRNA)-mediated genetic screens in mammalian cells are powerful tools for discovering loss-of-function phenotypes. We describe a…”
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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis by Schmelzle, Tobias, Mailleux, Arnaud A, Overholtzer, Michael, Carroll, Jason S, Solimini, Nicole L, Lightcap, Eric S, Veiby, Ole P, Brugge, Joan S

“…The formation of a lumen in three-dimensional mammary epithelial acinar structures in vitro involves selective apoptosis of centrally localized cells that lack…”
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STOP gene Phactr4 is a tumor suppressor by Solimini, Nicole L, Liang, Anthony C, Xu, Chunxiao, Pavlova, Natalya N, Xu, Qikai, Davoli, Teresa, Li, Mamie Z, Wong, Kwok-Kin, Elledge, Stephen J

“…Significance Cell proliferation control is central to tumor suppression. We previously identified hundreds of suppressors of tumorigenesis and/or proliferation…”
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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction by Luo, Ji, Solimini, Nicole L., Elledge, Stephen J.

“…Cancer is a complex collection of distinct genetic diseases united by common hallmarks. Here, we expand upon the classic hallmarks to include the stress…”
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Autoantigen discovery with a synthetic human peptidome by Solimini, Nicole L, Elledge, Stephen J, Larman, H Benjamin, Zhao, Zhenming, Laserson, Uri, Li, Mamie Z, Ciccia, Alberto, Gakidis, M Angelica Martinez, Church, George M, Kesari, Santosh, LeProust, Emily M

“…Larman et al . create a phage library containing >400,000 sequences encoding peptides that cover all open reading frames in the human genome. They then use…”
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PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis by Larman, H. Benjamin, Laserson, Uri, Querol, Luis, Verhaeghen, Katrijn, Solimini, Nicole L, Xu, George Jing, Klarenbeek, Paul L, Church, George M, Hafler, David A, Plenge, Robert M, Nigrovic, Peter A, De Jager, Philip L, Weets, Ilse, Martens, Geert A, O'Connor, Kevin C, Elledge, Stephen J

“…Abstract Autoimmune disease results from a loss of tolerance to self-antigens in genetically susceptible individuals. Completely understanding this process…”
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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2 by Worster, Devin T, Schmelzle, Tobias, Solimini, Nicole L, Lightcap, Eric S, Millard, Bjorn, Mills, Gordon B, Brugge, Joan S, Albeck, John G

“…Epithelial cells respond to growth factors including epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), and insulin. Using high-content…”
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Abstract 604: Targeting casein kinase 1 alpha (CK1 alpha) and transcriptional CDKs (CDK7/9) in human liposarcomas by Liu, Renyan, Solimini, Nicole L., Bhola, Patrick, Branigan, Timothy B., Hao, Jie, Wang, Xin, Alharthi, Roshen, Yorsz, Michael, Soni, Shaili, Hu, Cing-siang, Snir-Alkalay, Irit, Gokhale, Prafulla, Letai, Anthony, Ben-Neriah, Yinon Yinon, Demetri, George D., Shapiro, Geoffrey I.

“…Abstract Introduction: Liposarcomas (LPS) are rare mesenchymal cell malignancies of adipocytic origin that are diagnosed in more than 3500 patients in the US…”
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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction by Luo, Ji, Solimini, Nicole L., Elledge, Stephen J.

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STOP gene Phactr4 is a tumor suppressor by Solimini, Nicole L., Liang, Anthony C., Xu, Chunxiao, Pavlova, Natalya N., Xu, Qikai, Davoli, Teresa, Li, Mamie Z., Wong, Kwok-Kin, Elledge, Stephen J.

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Abstract IA28: Haploinsufficiency in cancer by Davoli, Teresa, Solimini, Nicole L., Pavlova, Natalya N., Xu, Qikai, Mengwasser, Kristen, Sack, Laura M., Liang, Anthony C., Schlabach, Michael R., Luo, Ji, Burrows, Anna E., Anselmo, Anthony N., Li, Mamie Z., Elledge, Stephen J.

“…Abstract Breast cancer is a collection of diseases with distinct clinical behaviors and underlying genetic causes. We have searched genetically for genes that…”
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Abstract IA8: Genetic approaches to cancer by Solimini, Nicole L., Bredemeyer, Andrea L., Li, Mamie Z., Beroukhim, Rameen, Meyerson, Matthew, Elledge, Stephen J., Pavlova, Natalya N., Xu, Qikai, Mermel, Craig H., Liang, Anthony C., Schlabach, Michael R., Luo, Ji, Burrows, Anna E., Anselmo, Anthony N.

“…Abstract Breast cancer is a collection of diseases with distinct clinical behaviors and underlying genetic causes. We have searched genetically for genes that…”
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Application of a synthetic human proteome to autoantigen discovery through PhIP-Seq by Larman, H. Benjamin, Zhao, Zhenming, Laserson, Uri, Li, Mamie Z., Ciccia, Alberto, Gakidis, M. Angelica Martinez, Church, George M., Kesari, Santosh, LeProust, Emily M., Solimini, Nicole L., Elledge, Stephen J.

“…In this study, we improve on current autoantigen discovery approaches by creating a synthetic representation of the complete human proteome, the T7 “peptidome”…”
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Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis by Kessler, Jessica D., Kahle, Kristopher T., Sun, Tingting, Meerbrey, Kristen L., Schlabach, Michael R., Schmitt, Earlene M., Skinner, Samuel O., Xu, Qikai, Li, Mamie Z., Hartman, Zachary C., Rao, Mitchell, Yu, Peng, Dominguez-Vidana, Rocio, Liang, Anthony C., Solimini, Nicole L., Bernardi, Ronald J., Yu, Bing, Hsu, Tiffany, Golding, Ido, Luo, Ji, Osborne, C. Kent, Creighton, Chad, Hilsenbeck, Susan G., Schiff, Rachel, Shaw, Chad A., Elledge, Stephen J., Westbrook, Thomas F.

“…Abstract Myc is an oncogenic transcription factor frequently dysregulated in human malignancies. While the transcriptional programs and other functions of Myc…”
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