Search Results - "Solheim, Joyce C."

Cancer-associated mucins: role in immune modulation and metastasis by Bhatia, Rakesh, Gautam, Shailendra K., Cannon, Andrew, Thompson, Christopher, Hall, Bradley R., Aithal, Abhijit, Banerjee, Kasturi, Jain, Maneesh, Solheim, Joyce C., Kumar, Sushil, Batra, Surinder K.

“…Mucins (MUC) protect epithelial barriers from environmental insult to maintain homeostasis. However, their aberrant overexpression and glycosylation in various…”
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Gemcitabine Modulates HLA-I Regulation to Improve Tumor Antigen Presentation by Pancreatic Cancer Cells by Larson, Alaina C, Knoche, Shelby M, Brumfield, Gabrielle L, Doty, Kenadie R, Gephart, Benjamin D, Moore-Saufley, Promise R, Solheim, Joyce C

“…Pancreatic cancer is a lethal disease, harboring a five-year overall survival rate of only 13%. Current treatment approaches thus require modulation, with…”
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The double life of a chemotherapy drug: Immunomodulatory functions of gemcitabine in cancer by Larson, Alaina C., Doty, Kenadie R., Solheim, Joyce C.

“…Although the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune‐based…”
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The histone deacetylase inhibitor M344 as a multifaceted therapy for pancreatic cancer by Knoche, Shelby M, Brumfield, Gabrielle L, Goetz, Benjamin T, Sliker, Bailee H, Larson, Alaina C, Olson, Madeline T, Poelaert, Brittany J, Bavari, Audrey, Yan, Ying, Black, Jennifer D, Solheim, Joyce C

“…The histone deacetylase (HDAC) inhibitor vorinostat, used with gemcitabine and other therapies, has been effective in treatment of experimental models of…”
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer by Pandey, Poomy, Sliker, Bailee, Peters, Haley L, Tuli, Amit, Herskovitz, Jonathan, Smits, Kaitlin, Purohit, Abhilasha, Singh, Rakesh K, Dong, Jixin, Batra, Surinder K, Coulter, Donald W, Solheim, Joyce C

“…Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1…”
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Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival by ZHENGTANG CHEN, VARNEY, Michelle L, BACKORA, Matthew W, COWAN, Kenneth, SOLHEIM, Joyce C, TALMADGE, James E, SINGH, Rakesh K

“…Tumor production of vascular endothelial cell growth factor (VEGF)-C is associated with tumor lymphangiogenesis and lymph node metastasis. In this study, we…”
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Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain by Simone, Laura C., Georgesen, Corey J., Simone, Peter D., Wang, Xiaojian, Solheim, Joyce C.

“…► Tapasin Δ334–342, but not soluble tapasin, facilitates murine MHC class I surface expression. ► Soluble tapasin has a dominant negative effect over tapasin…”
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Mechanism for Amyloid Precursor-like Protein 2 Enhancement of Major Histocompatibility Complex Class I Molecule Degradation by Tuli, Amit, Sharma, Mahak, Capek, Haley L., Naslavsky, Naava, Caplan, Steve, Solheim, Joyce C.

“…Earlier studies have demonstrated interaction of the murine major histocompatibility complex (MHC) class I molecule Kd with amyloid precursor-like protein 2…”
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Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert by Li, Xiaoqi, Gulati, Mansi, Larson, Alaina C., Solheim, Joyce C., Jain, Maneesh, Kumar, Sushil, Batra, Surinder K.

“…Pancreatic cancer (PC) has exceptionally high mortality due to ineffective treatment strategies. Immunotherapy, which mobilizes the immune system to fight…”
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Virus evasion of MHC class I molecule presentation by Petersen, Jason L, Morris, Chantey R, Solheim, Joyce C

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Emerging trends in the immunotherapy of pancreatic cancer by Banerjee, Kasturi, Kumar, Sushil, Ross, Kathleen A., Gautam, Shailendra, Poelaert, Brittany, Nasser, Mohd Wasim, Aithal, Abhijit, Bhatia, Rakesh, Wannemuehler, Michael J., Narasimhan, Balaji, Solheim, Joyce C., Batra, Surinder K., Jain, Maneesh

“…Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in the U.S., claiming approximately 43,000 lives every year. Much like other solid…”
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Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β by Liu, Luman, Kshirsagar, Prakash, Christiansen, John, Gautam, Shailendra K., Aithal, Abhijit, Gulati, Mansi, Kumar, Sushil, Solheim, Joyce C., Batra, Surinder K., Jain, Maneesh, Wannemuehler, Michael J., Narasimhan, Balaji

“…Pancreatic cancer (PC) is one of the most lethal malignancies and represents an increasing and challenging threat, especially with an aging population. The…”
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The role of tumor heterogeneity in immune-tumor interactions by Knoche, Shelby M., Larson, Alaina C., Sliker, Bailee H., Poelaert, Brittany J., Solheim, Joyce C.

“…The development of cancer stems from genetic instability and changes in genomic sequences, and hence, the heterogeneity exhibited by tumors is integral to the…”
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Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies by Liu, Luman, Kshirsagar, Prakash G, Gautam, Shailendra K, Gulati, Mansi, Wafa, Emad I, Christiansen, John C, White, Brianna M, Mallapragada, Surya K, Wannemuehler, Michael J, Kumar, Sushil, Solheim, Joyce C, Batra, Surinder K, Salem, Aliasger K, Narasimhan, Balaji, Jain, Maneesh

“…Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and distribution of drugs within pancreatic tumors are compromised due to intrinsic…”
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Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor by Knoche, Shelby M., Larson, Alaina C., Brumfield, Gabrielle L., Cate, Steven, Hildebrand, William H., Solheim, Joyce C.

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HLA-B influences integrin beta-1 expression and pancreatic cancer cell migration by Sliker, Bailee H., Goetz, Benjamin T., Barnes, Raina, King, Hannah, Maurer, H. Carlo, Olive, Kenneth P., Solheim, Joyce C.

“…Human leukocyte antigen (HLA) class I molecules present antigenic peptides to cytotoxic T cells, causing lysis of malignant cells. Transplantation biology…”
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Contribution of CXCR3-mediated signaling in the metastatic cascade of solid malignancies by Cannon, Andrew, Thompson, Christopher M., Bhatia, Rakesh, Kandy, Rakhee R.K., Solheim, Joyce C., Batra, Surinder K., Kumar, Sushil

“…Metastasis is a significant cause of the mortality resulting from solid malignancies. The process of metastasis is complex and is regulated by numerous cancer…”
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A Charged Amino Acid Residue in the Transmembrane/Cytoplasmic Region of Tapasin Influences MHC Class I Assembly and Maturation by Petersen, Jason L, Hickman-Miller, Heather D, McIlhaney, Mary M, Vargas, Shanna E, Purcell, Anthony W, Hildebrand, William H, Solheim, Joyce C

“…Tapasin influences the quantity and quality of MHC/peptide complexes at the cell surface; however, little is understood about the structural features that…”
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Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor by Knoche, Shelby M., Larson, Alaina C., Brumfield, Gabrielle L., Cate, Steven, Hildebrand, William H., Solheim, Joyce C.

“…Pancreatic cancer is one of the deadliest neoplasms, with a dismal 5-year survival rate of only 10%. The ability of pancreatic cancer cells to evade the immune…”
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Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells by Sliker, Bailee H., Goetz, Benjamin T., Peters, Haley L., Poelaert, Brittany J., Borgstahl, Gloria E. O., Solheim, Joyce C.

“…Beta 2-microglobulin (β 2 m) is a component of the major histocompatibility complex (MHC) class I molecule, which presents tumor antigens to T lymphocytes to…”
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