Search Results - "Solesio, Maria E."

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore by Neginskaya, Maria A., Solesio, Maria E., Berezhnaya, Elena V., Amodeo, Giuseppe F., Mnatsakanyan, Nelli, Jonas, Elizabeth A., Pavlov, Evgeny V.

“…Permeability transition (PT) is an increase in mitochondrial inner membrane permeability that can lead to a disruption of mitochondrial function and cell…”
Get full text

ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer's Disease by Patro, Somya, Ratna, Sujay, Yamamoto, Hianny A, Ebenezer, Andrew T, Ferguson, Dillon S, Kaur, Amanpreet, McIntyre, Brendan C, Snow, Ryan, Solesio, Maria E

“…Alzheimer's Disease (AD) is the most common neurodegenerative disorder in our society, as the population ages, its incidence is expected to increase in the…”
Get full text

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain by Fossati, Silvia, Giannoni, Patrizia, Solesio, Maria E, Cocklin, Sarah L, Cabrera, Erwin, Ghiso, Jorge, Rostagno, Agueda

“…Abstract Mitochondrial dysfunction has been recognized as an early event in Alzheimer's disease (AD) pathology, preceding and inducing neurodegeneration and…”
Get full text

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice by Liu, Zhongbo, Solesio, Maria E, Schaffler, Mitchell B, Frikha‐Benayed, Dorra, Rosen, Clifford J, Werner, Haim, Kopchick, John J, Pavlov, Evgeny V, Abramov, Andrey Y, Yakar, Shoshana

“…ABSTRACT Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRKO) mice exhibit severe skeletal impairment. The…”
Get full text

Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics by Scoma, Ernest R., Da Costa, Renata T., Leung, Ho Hang, Urquiza, Pedro, Guitart-Mampel, Mariona, Hambardikar, Vedangi, Riggs, Lindsey M., Wong, Ching-On, Solesio, Maria E.

“…Inorganic polyphosphate (polyP) is an evolutionarily conserved and ubiquitous polymer that is present in all studied organisms. PolyP consists of…”
Get full text

Mitochondrial inorganic polyphosphate (polyP): the missing link of mammalian bioenergetics by McIntyre, Brendan, Solesio, Maria

Get full text

Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore by Solesio, Maria E, Elustondo, Pia A, Zakharian, Eleonora, Pavlov, Evgeny V

“…Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological…”
Get more information

Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection by Baduini, Isabella R., Castro Vildosola, Jose E., Kavehmoghaddam, Sheida, Kiliç, Fatmanur, Nadeem, S. Aiman, Nizama, Juan J., Rowand, Marietta A., Annapureddy, Dileep, Bryan, Chris-Ann, Do, Lisa H., Hsiao, Samuel, Jonnalagadda, Sai A., Kasturi, Akhila, Mandava, Nikhila, Muppavaram, Sachin, Ramirez, Bryan, Siner, Aleece, Suoto, Christina N., Tamajal, Nasira, Scoma, Ernest R., Da Costa, Renata T., Solesio, Maria E.

“…The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent decades as the population ages, and this trend is not expected to…”
Get full text

Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration? by Borden, Emily A., Furey, Matthew, Gattone, Nicholas J., Hambardikar, Vedangi D., Liang, Xiao Hua, Scoma, Ernest R., Abou Samra, Antonella, D-Gary, LaKeshia R., Dennis, Dayshaun J., Fricker, Daniel, Garcia, Cindy, Jiang, ZeCheng, Khan, Shariq A., Kumarasamy, Dheenadhayalan, Kuppala, Hasmitha, Ringrose, Savannah, Rosenheim, Evan J., Van Exel, Kimberly, Vudhayagiri, Hemanth Sai, Zhang, Jiarui, Zhang, Zhaowen, Guitart-Mampel, Mariona, Urquiza, Pedro, Solesio, Maria E.

“…[Display omitted] Mitochondrial dysfunction – including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional…”
Get full text

The Glacier Ice Worm, Mesenchytraeus solifugus , Elevates Mitochondrial Inorganic Polyphosphate (PolyP) Levels in Response to Stress by Osorio, Teresa, Scoma, Ernest R, Shain, Daniel H, Melissaratos, Diana S, Riggs, Lindsey M, Hambardikar, Vedangi, Solesio, Maria E

“…The inorganic polymer, polyphosphate (polyP), is present in all organisms examined to date with putative functions ranging from the maintenance of…”
Get full text

From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore by Amodeo, Giuseppe Federico, Solesio, Maria E., Pavlov, Evgeny V.

Get full text

Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells by Hambardikar, Vedangi, Guitart-Mampel, Mariona, Scoma, Ernest R, Urquiza, Pedro, Nagana, Gowda G A, Raftery, Daniel, Collins, John A, Solesio, Maria E

“…Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows…”
Get full text

Impact of Aldosterone on the Failing Myocardium: Insights from Mitochondria and Adrenergic Receptors Signaling and Function by Guitart-Mampel, Mariona, Urquiza, Pedro, Borges, Jordana I., Lymperopoulos, Anastasios, Solesio, Maria E.

“…The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but it also adversely modulates the structure and function of the…”
Get full text

Mitochondrial Inorganic Polyphosphate (polyP) Is a Potent Regulator of Mammalian Bioenergetics in SH-SY5Y Cells: A Proteomics and Metabolomics Study by Guitart-Mampel, Mariona, Urquiza, Pedro, Carnevale Neto, Fausto, Anderson, James R, Hambardikar, Vedangi, Scoma, Ernest R, Merrihew, Gennifer E, Wang, Lu, MacCoss, Michael J, Raftery, Daniel, Peffers, Mandy J, Solesio, Maria E

“…Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer which is present in all the studied organisms. It is formed by individual…”
Get full text

Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle by Da Costa, Renata T, Urquiza, Pedro, Perez, Matheus M, Du, YunGuang, Khong, Mei Li, Zheng, Haiyan, Guitart-Mampel, Mariona, Elustondo, Pia A, Scoma, Ernest R, Hambardikar, Vedangi, Ueberheide, Beatrix, Tanner, Julian A, Cohen, Alejandro, Pavlov, Evgeny V, Haynes, Cole M, Solesio, Maria E

“…The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle…”
Get full text

Toolkit for cellular studies of mammalian mitochondrial inorganic polyphosphate by Hambardikar, Vedangi, Akosah, Yaw A, Scoma, Ernest R, Guitart-Mampel, Mariona, Urquiza, Pedro, Da Costa, Renata T, Perez, Matheus M, Riggs, Lindsey M, Patel, Rajesh, Solesio, Maria E

“…Inorganic polyphosphate (polyP) is an ancient polymer which is extremely well-conserved throughout evolution, and found in every studied organism. PolyP is…”
Get full text

Role of inorganic polyphosphates in the activation of AMPK in models of Alzheimer's disease by Riggs, Lindsey M., Torregrosa, Maria E. Solesio

Get full text

Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury by Castro, Cristina M., Corciulo, Carmen, Solesio, Maria E., Liang, Fengxia, Pavlov, Evgeny V., Cronstein, Bruce N.

“…In OA chondrocytes, there is diminished mitochondrial production of ATP and diminished extracellular adenosine resulting in diminished adenosine A2A receptor…”
Get full text

Inorganic polyphosphate and the regulation of mitochondrial physiology by Da Costa, Renata T, Riggs, Lindsey M, Solesio, Maria E

“…Inorganic polyphosphate (polyP) is an ancient polymer that is well-conserved throughout evolution. It is formed by multiple subunits of orthophosphates linked…”
Get more information

Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria‐mediated cell death by Perez‐Alvarez, Sergio, Solesio, Maria E, Manzanares, Jorge, Jordán, Joaquín, Galindo, María F

“…Background and purpose:  The proteasome inhibitor model of Parkinson's disease (PD) appears to reproduce many of the important behavioural, imaging,…”
Get full text