Search Results - "Solesio, María E"
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Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity
Published in Aging cell (01-08-2018)“…Summary Mounting evidence suggests that mitochondrial dysfunction plays a causal role in the etiology and progression of Alzheimer's disease (AD). We recently…”
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The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease
Published in Biochimica et biophysica acta (01-01-2013)“…Parkinson's disease (PD) is a neurodegenerative disorder for which available treatments provide symptom relief but do not stop disease progression…”
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3
Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder
Published in Pharmacological research (01-02-2023)“…Fetal alcohol spectrum disorder (FASD) includes neuropsychiatric disturbances related to gestational and lactational ethanol exposure. Available treatments are…”
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Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine
Published in Neurobiology of aging (01-02-2012)“…Abstract The role of CB2 cannabinoid receptors in the behavioral and neurochemical changes induced by intracaudate administration of 6-hydroxydopamine (6-OHDA)…”
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Methadone induces CAD degradation and AIF-mediated necrotic-like cell death in neuroblastoma cells
Published in Pharmacological research (01-04-2011)“…Methadone ( d, l-methadone hydrochloride) is a full-opioid agonist, originally developed as a substitution for heroin or other opiates abusers. Nowadays…”
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ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore
Published in Cell reports (Cambridge) (02-01-2019)“…Permeability transition (PT) is an increase in mitochondrial inner membrane permeability that can lead to a disruption of mitochondrial function and cell…”
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ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer's Disease
Published in International journal of molecular sciences (17-10-2021)“…Alzheimer's Disease (AD) is the most common neurodegenerative disorder in our society, as the population ages, its incidence is expected to increase in the…”
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The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain
Published in Neurobiology of disease (01-02-2016)“…Abstract Mitochondrial dysfunction has been recognized as an early event in Alzheimer's disease (AD) pathology, preceding and inducing neurodegeneration and…”
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Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice
Published in Journal of bone and mineral research (01-01-2019)“…ABSTRACT Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRKO) mice exhibit severe skeletal impairment. The…”
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Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics
Published in International journal of molecular sciences (01-09-2023)“…Inorganic polyphosphate (polyP) is an evolutionarily conserved and ubiquitous polymer that is present in all studied organisms. PolyP consists of…”
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Mitochondrial inorganic polyphosphate (polyP): the missing link of mammalian bioenergetics
Published in Neural regeneration research (01-11-2021)Get full text
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Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore
Published in Biochemical Society transactions (15-02-2016)“…Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological…”
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Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection
Published in Pharmacological research (01-11-2024)“…The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent decades as the population ages, and this trend is not expected to…”
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Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?
Published in Pharmacological research (01-01-2021)“…[Display omitted] Mitochondrial dysfunction – including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional…”
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The Glacier Ice Worm, Mesenchytraeus solifugus , Elevates Mitochondrial Inorganic Polyphosphate (PolyP) Levels in Response to Stress
Published in Biology (Basel, Switzerland) (06-12-2022)“…The inorganic polymer, polyphosphate (polyP), is present in all organisms examined to date with putative functions ranging from the maintenance of…”
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From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore
Published in Cell death & disease (04-12-2017)Get full text
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Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells
Published in Antioxidants (31-03-2022)“…Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows…”
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Impact of Aldosterone on the Failing Myocardium: Insights from Mitochondria and Adrenergic Receptors Signaling and Function
Published in Cells (Basel, Switzerland) (19-06-2021)“…The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but it also adversely modulates the structure and function of the…”
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Mitochondrial Inorganic Polyphosphate (polyP) Is a Potent Regulator of Mammalian Bioenergetics in SH-SY5Y Cells: A Proteomics and Metabolomics Study
Published in Frontiers in cell and developmental biology (17-02-2022)“…Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer which is present in all the studied organisms. It is formed by individual…”
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Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle
Published in Frontiers in cell and developmental biology (10-07-2024)“…The existing literature points towards the presence of robust mitochondrial mechanisms aimed at mitigating protein dyshomeostasis within the organelle…”
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