Diet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a Possible Role of Neutrophilic Inflammation

Diet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a Possible Role of Neutrophilic Inflammation

Chicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary re...

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Bibliographic Details
Published in:Inflammation Vol. 42; no. 5; pp. 1886 - 1900
Main Authors: Vedova, M. C. Della, Soler Garcia, F. M., Muñoz, M. D., Fornes, M. W., Gomez Mejiba, Sandra E., Gómez, N. N., Ramirez, Dario C.
Format: Journal Article
Language:English
Published: New York Springer US 01-10-2019
Springer Nature B.V
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell activation
Diet
Diet, High-Fat - adverse effects
Drinking water
Fibrosis
Fibrosis - etiology
Food
Food additives
Food processing
Fructose
Immunology
Inflammation
Inflammation - etiology
Internal Medicine
Leukocytes (neutrophilic)
Low fat diet
Lung - metabolism
Lung diseases
Metabolic syndrome
Mice
Neutrophils - pathology
Nutrient deficiency
Original Article
Oxidation-Reduction
Oxidative Stress
Pathology
Peroxidase
Pharmacology/Toxicology
Pneumonia - etiology
Pneumonia - metabolism
Pneumonia - pathology
Rheumatology
metabolic syndrome
neutrophilic inflammation
incipient lung fibrosis
myeloperoxidase
diet
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Summary:Chicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes in the organ histophysiology. To test this hypothesis, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat and with or without 10% fructose in the drinking water. At the end of the feeding regimen, we measured redox and inflammatory changes in the lung with particular emphasis on neutrophil accumulation/activation and molecular-histological markers of fibrosis. Our results suggest that a diet supplemented with chicken fat and fructose causes additive effects on pulmonary oxidative stress, inflammation, and a pro-fibrotic status. Neutrophilic inflammation may play a critical role in pulmonary pathology associated with metabolic syndrome.
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ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-019-01051-9