THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME

THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME

Short bowel syndrome is a harmful condition that needs experimental research. To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. Fifteen Wistar rats were equitable divided into: Control (...

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Bibliographic Details
Published in:Arquivos brasileiros de cirurgia digestiva : ABCD Vol. 32; no. 1; p. e1417
Main Authors: Soler, Wangles Vasconcellos, Lee, Andre Dong, D'Albuquerque, Eugênia Machado Carneiro, Capelozzi, Vera, Albuquerque, Luiz Carneiro, Capelhuchnick, Peretz, Lancelotti, Carmem Penteado, Galvão, Flavio Henrique Ferreira
Format: Journal Article
Language:English
Published: Brazil Colégio Brasileiro de Cirurgia Digestiva 01-01-2019
Subjects:
Animals
Biopsy
Body Weight
Colon - pathology
Colon - surgery
Disease Models, Animal
Ileocecal Valve - pathology
Ileocecal Valve - surgery
Intestinal mucosa
Intestinal Mucosa - pathology
Intestinal Mucosa - surgery
Intestine, Small - pathology
Intestine, Small - surgery
Jejunoileal Bypass - methods
Male
Original
Protein malnutrition
Random Allocation
Rats, Wistar
Reproducibility of Results
Short bowel syndrome
Short Bowel Syndrome - pathology
Short Bowel Syndrome - surgery
Time Factors
Treatment Outcome
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Summary:Short bowel syndrome is a harmful condition that needs experimental research. To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30th postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. This short bowel syndrome model is relevant and achieve 100% of survival. Animal's weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve.
Bibliography:Conflict of interest: none
ISSN:0102-6720
2317-6326
DOI:10.1590/0102-672020180001e1417