Search Results - "Soldner, Emma L. B."

P‑gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy by Hartz, Anika M. S, Pekcec, Anton, Soldner, Emma L. B, Zhong, Yu, Schlichtiger, Juli, Bauer, Bjoern

“…A cure for epilepsy is currently not available, and seizure genesis, seizure recurrence, and resistance to antiseizure drugs remain serious clinical problems…”
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Amyloid-β Contributes to Blood―Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy by HARTZ, Anika M. S, BAUER, Björn, SCHLACHETZKI, Felix, SOLDNER, Emma L. B, WOLF, Andrea, BOY, Sandra, BACKHAUS, Roland, MIHALJEVIC, Ivan, BOGDAHN, Ulrich, KLÜNEMANN, Hans H, SCHUIERER, Gerhard

“…Cerebral amyloid angiopathy (CAA) is a degenerative disorder characterized by amyloid-β (Aβ) deposition in the blood-brain barrier (BBB). CAA contributes to…”
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Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy by Rempe, Ralf G, Hartz, Anika M S, Soldner, Emma L B, Sokola, Brent S, Alluri, Satya R, Abner, Erin L, Kryscio, Richard J, Pekcec, Anton, Schlichtiger, Juli, Bauer, Björn

“…The blood-brain barrier is dysfunctional in epilepsy, thereby contributing to seizure genesis and resistance to antiseizure drugs. Previously, several groups…”
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Inhibition of human microsomal PGE2 synthase‐1 reduces seizure‐induced increases of P‐glycoprotein expression and activity at the blood‐brain barrier by Soldner, Emma L. B., Hartz, Anika M. S., Akanuma, Shin‐Ichi, Pekcec, Anton, Doods, Henri, Kryscio, Richard J., Hosoya, Ken‐Ichi, Bauer, Björn

“…The cause of antiseizure drug (ASD) resistance in epilepsy is poorly understood. Here, we focus on the transporter P‐glycoprotein (P‐gp) that is partly…”
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Chronic placental ischemia alters amniotic fluid milieu and results in impaired glucose tolerance, insulin resistance and hyperleptinemia in young rats by Heltemes, Alaina, Gingery, Anne, Soldner, Emma L B, Bozadjieva, Nadejda, Jahr, Kristen N, Johnson, Britt K, Gilbert, Jeffrey S

“…Although small size at birth is associated with hypertension and associated co-morbidities such as insulin resistance and type II diabetes mellitus, many of…”
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Cytosolic phospholipase A2 is a key regulator of blood‐brain barrier function in epilepsy by Hartz, Anika M. S., Rempe, Ralf G., Soldner, Emma L. B., Pekcec, Anton, Schlichtiger, Juli, Kryscio, Richard, Bauer, Bjoern

“…Blood‐brain barrier dysfunction in epilepsy contributes to seizures and resistance to antiseizure drugs. Reports show that seizures increase brain glutamate…”
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Developmental programming of the kidney: does sex matter? by Gingery, Anne, Soldner, Emma L. B., Heltemes, Alaina, Nelson, Adam, Bozadjieva, Nadejda

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Soluble endoglin inhibits breast cancer cell proliferation by Gingery, Anne, Nelson, Adam M, Soldner, Emma L B, Gilbert, Jeffrey S

“…While recent studies indicate preeclampsia may be associated with reduced incidence of breast cancer, the exact mechanisms underlying this observation remain…”
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Chronic placental ischemia decreases insulin‐like growth factor‐1 during late gestation in the rat by Bozadjieva, Nadejda Ivanova, Soldner, Emma L B, Heltemes, Alaina, Gingery, Anne, Gilbert, Jeffrey S

“…Preeclampsia and other pregnancy related hypertensive disorders affect ~ 8 % of all pregnancies and are a major source of maternal and neonatal morbidity and…”
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Hyperleptinemia and glucose intolerance in rat offspring with long‐term placental insufficiency by Heltemes, Alaina, Soldner, Emma L. B., Bozadjieva, Nedejda, Gingery, Anne, Gilbert, Jeffrey S

“…Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR) in western societies and is associated with the development of chronic…”
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Vascular endothelial growth factor antagonism inhibits breast cancer proliferation via Akt and Erk signaling by Nelson, Adam Michael, Gingery, Anne, Soldner, Emma L B, Gilbert, Jeffrey S

“…While recent epidemiological studies report preeclampsia has long‐term protective effects against breast cancer, the mechanisms and the factors responsible for…”
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