Search Results - "Soldato, P"

The hydrogen sulphide‐releasing derivative of diclofenac protects against ischaemia–reperfusion injury in the isolated rabbit heart by Rossoni, G, Sparatore, A, Tazzari, V, Manfredi, B, Soldato, P Del, Berti, F

“…Background and purpose: Hydrogen sulphide (H2S) is an endogenous gaseous mediator active in the multilevel regulation of pathophysiological functions in…”
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Modulation of angiogenesis by dithiolethione‐modified NSAIDs and valproic acid by Isenberg, J S, Jia, Y, Field, L, Ridnour, L A, Sparatore, A, Soldato, P, Sowers, A L, Yeh, G C, Moody, T W, Wink, D A, Ramchandran, R, Roberts, D D

“…Background and purpose: Angiogenesis involves multiple signaling pathways that must be considered when developing agents to modulate pathological angiogenesis…”
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Nitric-oxide releasing molecules: a new class of drugs with several major indications by Burgaud, J L, Riffaud, J P, Del Soldato, P

“…Nitric oxide (NO) deficiency has been implicated in many pathological and physiological processes within the mammalian body providing a plausible biologic…”
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Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity by Switzer, C H, Ridnour, L A, Cheng, R Y S, Sparatore, A, Del Soldato, P, Moody, T W, Vitek, M P, Roberts, D D, Wink, D A

“…The chemopreventative effects of dithiolethione compounds are attributed to their activation of antioxidant response elements (AREs) by reacting with the…”
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Hydrogen sulphide‐releasing diclofenac derivatives inhibit breast cancer‐induced osteoclastogenesis in vitro and prevent osteolysis ex vivo by Frantzias, J, Logan, JG, Mollat, P, Sparatore, A, Del Soldato, P, Ralston, SH, Idris, AI

“…BACKGROUND AND PURPOSE Hydrogen sulphide (H2S) and prostaglandins are both involved in inflammation, cancer and bone turnover, and non‐steroidal…”
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H2S RELEASING ASPIRIN PROTECTS AMYLOID BETA INDUCED CELL TOXICITY IN BV-2 MICROGLIAL CELLS by LIU, Y.-Y, SPARATORE, A, DEL SOLDATO, P, BIAN, J.-S

“…β-Amyloid (Aβ) plaques are characteristic hallmarks of Alzheimer's disease. In the present study, we examined the neuroprotective effects of S-aspirin, a…”
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Corrigendum to “H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells” [Neuroscience 193 (2011) 80–88] by Liu, Y.-Y, Sparatore, A, Del Soldato, P, Bian, J.-S

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Interaction of a Selective Cyclooxygenase-2 Inhibitor with Aspirin and NO-Releasing Aspirin in the Human Gastric Mucosa by Fiorucci, Stefano, Santucci, Luca, Wallace, John L., Sardina, Marco, Romano, Mario, del Soldato, Piero, Morelli, Antonio

“…In addition to inhibiting cyclooxygenase (COX)-1-derived prostanoid biosynthesis, aspirin acetylates COX-2, enabling the conversion of arachidonic acid to…”
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NO-aspirin: mechanism of action and gastrointestinal safety by Fiorucci, S, Del Soldato, P

“…Nitric oxide-releasing aspirins are new chemical entities obtained by adding a nitric oxide-releasing moiety to aspirin. NCX-4016 is the prototype of this…”
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IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs by Fiorucci, S, Santucci, L, Cirino, G, Mencarelli, A, Familiari, L, Soldato, P D, Morelli, A

“…Caspase-1, the IL-1beta converting enzyme (ICE), is required for intracellular processing/maturation of IL-1beta and IL-18. NO releasing nonsteroidal…”
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New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma by Wedel, S. A., Sparatore, A., Soldato, P. D., Al‐Batran, S.‐E., Atmaca, A., Juengel, E., Hudak, L., Jonas, D., Blaheta, R. A.

“…The anti‐epileptic drug valproic acid is also under trial as an anti‐cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the…”
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Identification of hydrogen sulfide releasing compounds as novel antiresorptive and antitumour agents by Idris, A.I, Frantzias, J, Mollat, P, Sparatore, A, Del Soldato, P, Ralston, S.H

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Gastrointestinal safety of nitric oxide–derived aspirin is related to inhibition of ICE-like cysteine proteases in rats by Fiorucci, Stefano, Antonelli, Elisabetta, Santucci, Luca, Morelli, Olivia, Miglietti, Maria, Federici, Barbara, Mannucci ‡, Roberta, Soldato §, Piero Del, Morelli, Antonio

“…Background & Aims: Caspases, a class of cysteine proteases, modulate apoptosis. Nitric oxide (NO)-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) are a…”
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Effects of non‐steroidal anti‐inflammatory drugs on cyclo‐oxygenase and lipoxygenase activity in whole blood from aspirin‐sensitive asthmatics vs healthy donors by Gray, P A, Warner, T D, Vojnovic, I, Del Soldato, P, Parikh, A, Scadding, G K, Mitchell, J A

“…Cyclo‐oxygenase (COX) and lipoxygenase (LO) share a common substrate, arachidonic acid. Aspirin and related drugs inhibit COX activity. In a subset of patients…”
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A comparison of the anti‐inflammatory and anti‐nociceptive activity of nitroaspirin and aspirin by Al‐Swayeh, O A, Clifford, R H, Del Soldato, P, Moore, P K

“…Nitroaspirin (2.5–50 mg kg−1, i.p. or 2.5–100 mg kg−1, p.o.) and aspirin (2.5–100 mg kg−1, i.p. or p.o.) exhibit anti‐inflammatory activity in the…”
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NO‐naproxen vs. naproxen: ulcerogenic, analgesic and anti‐inflammatory effects by DAVIES, N. M., RØSETH, A. G., APPLEYARD, C. B., MCKNIGHT, W., DEL SOLDATO, P., CALIGNANO, A., CIRINO, G., WALLACE, J. L.

“…Background: A novel class of nitric oxide‐releasing nonsteroidal anti‐inflammatory drug (NO‐NSAID) derivatives has recently been described which exert…”
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Nitric Oxide–Releasing Aspirin Derivative, NCX 4016, Promotes Reparative Angiogenesis and Prevents Apoptosis and Oxidative Stress in a Mouse Model of Peripheral Ischemia by Emanueli, Costanza, Van Linthout, Sophie, Salis, Maria Bonaria, Monopoli, Angela, Del Soldato, Piero, Ongini, Ennio, Madeddu, Paolo

“…BACKGROUND—Recently, nitric oxide (NO) donors have been developed that mimic the physiological intracellular release of NO. We evaluated whether one of these…”
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Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2 by Corazzi, Teresa, Leone, Mario, Roberti, Rita, Soldato, Piero Del, Gresele, Paolo

“…COX-2 is involved in inflammation and ischemic cardiovascular disease. As NO regulates COX activity in various cells, we investigated the effect of NO-donors…”
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Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats by Wallace, John L., Vergnolle, Nathalie, Muscará, Marcelo N., Asfaha, Samuel, Chapman, Kevin, McKnight, Webb, Soldato, Piero Del, Morelli, Antonio, Fiorucci, Stefano

“…Background & Aims: Nitric oxide (NO)-releasing derivatives of cyclooxygenase inhibitors exhibit enhanced anti-inflammatory activity and greatly reduced…”
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Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat by Fredduzzi, S., Mariucci, G., Tantucci, M., Del Soldato, P., Ambrosini, M.V.

“…The potential neuroprotective effects of the novel nitro-derivate of aspirin (NCX4016) on permanent focal cerebral ischemia in spontaneously hypertensive rats…”
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