Search Results - "Solchaga, Luis A"

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips and tricks by Solchaga, Luis A, Penick, Kitsie J, Welter, Jean F

“…It is well known that adult cartilage lacks the ability to repair itself; this makes articular cartilage a very attractive target for tissue engineering. The…”
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Human Mesenchymal Stromal Cells Attenuate Graft‐Versus‐Host Disease and Maintain Graft‐Versus‐Leukemia Activity Following Experimental Allogeneic Bone Marrow Transplantation by Auletta, Jeffery J., Eid, Saada K., Wuttisarnwattana, Patiwet, Silva, Ines, Metheny, Leland, Keller, Matthew D., Guardia‐Wolff, Rocio, Liu, Chen, Wang, Fangjing, Bowen, Theodore, Lee, Zhenghong, Solchaga, Luis A., Ganguly, Sudipto, Tyler, Megan, Wilson, David L., Cooke, Kenneth R.

“…We sought to define the effects and underlying mechanisms of human, marrow‐derived mesenchymal stromal cells (hMSCs) on graft‐versus‐host disease (GvHD) and…”
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The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration by Friedlaender, Gary E, Lin, Sheldon, Solchaga, Luis A, Snel, Leo B, Lynch, Samuel E

“…Recombinant human PDGF BB homodimer (rhPDGF-BB) is a potent recruiter of, and strong mitogenic factor for, cells crucial to musculoskeletal tissue repair,…”
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Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells by Solchaga, Luis A, Penick, Kitsie, Goldberg, Victor M, Caplan, Arnold I, Welter, Jean F

“…We compared human mesenchymal stem cells (hMSCs), expanded long term with and without fibroblast growth factor (FGF) supplementation, with respect to…”
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FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells by Solchaga, Luis A., Penick, Kitsie, Porter, John D., Goldberg, Victor M., Caplan, Arnold I., Welter, Jean F.

“…Human mesenchymal stem cells (hMSCs) expanded with and without fibroblast growth factor (FGF) supplementation were compared with respect to their proliferation…”
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Comparison of the effect of intra-tendon applications of recombinant human platelet-derived growth factor-BB, platelet-rich plasma, steroids in a rat achilles tendon collagenase model by Solchaga, Luis A., Bendele, Alison, Shah, Vivek, Snel, Leo B., Kestler, Hans K., Dines, Joshua S., Hee, Christopher K.

“…ABSTRACT This study compared the effect of intra‐tendon (IT) delivery of recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB), platelet‐rich plasma…”
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High-throughput aggregate culture system to assess the chondrogenic potential of mesenchymal stem cells by Penick, Kitsie J, Solchaga, Luis A, Welter, Jean F

“…We have developed an improved method for preparing cell aggregates for in vitro chondrogenesis studies. This method is a modification of a previously developed…”
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Safety of recombinant human platelet-derived growth factor-BB in Augment® Bone Graft by Solchaga, Luis A, Hee, Christopher K, Roach, Stephen, Snel, Leo B

“…This article discusses nonclinical and clinical data regarding the safety of recombinant human platelet-derived growth factor-BB as a component of the Augment®…”
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Bioreactors mediate the effectiveness of tissue engineering scaffolds by Pei, Ming, Solchaga, Luis A., Seidel, Joachim, Zeng, Li, Vunjak‐Novakovic, Gordana, Caplan, Arnold I., Freed, Lisa E.

“…ABSTRACT We hypothesized that the mechanically active environment present in rotating bioreactors mediates the effectiveness of three‐dimensional (3D)…”
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Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage by Solchaga, L A, Dennis, J E, Goldberg, V M, Caplan, A I

“…Culture-expanded bone marrow-derived mesenchymal progenitor cells differentiate into chondrocytes or osteoblasts when implanted subcutaneously in vivo in…”
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High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow by Woost, Philip G., Solchaga, Luis A., Meyerson, Howard J., Shankey, T. Vincent, Goolsby, Charles L., Jacobberger, James W.

“…Cytokine-mediated phosphorylation of Erk (pErk), ribosomal S6 (pS6), and Stat5 (pStat5) in CD34+/CD117+ blast cells in normal bone marrow from 9 healthy adult…”
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Simplification of aggregate culture of human mesenchymal stem cells as a chondrogenic screening assay by Welter, Jean F, Solchaga, Luis A, Penick, Kitsie J

“…Aggregate culture provides a three-dimensional (3-D) environment for differentiating or differentiated cells; it is particularly useful to study in vitro…”
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Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential by Solchaga, Luis A., Welter, Jean F., Zale, Elizabeth A., Auletta, Jeffery J.

“…Allogeneic hematopoietic stem cell transplantation is the main curative therapy for many hematologic malignancies. Its potential relies on graft-versus-tumor…”
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Assessing Adipogenic Potential of Mesenchymal Stem Cells: A Rapid Three-Dimensional Culture Screening Technique by Welter, Jean F., Penick, Kitsie J., Solchaga, Luis A.

“…Bone-marrow-derived mesenchymal stem cells (MSCs) have the potential to differentiate into a number of phenotypes, including adipocytes. Adipogenic…”
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Hyaluronan-based polymers in the treatment of osteochondral defects by Solchaga, L A, Yoo, J U, Lundberg, M, Dennis, J E, Huibregtse, B A, Goldberg, V M, Caplan, A I

“…Articular cartilage in adults has limited ability for self-repair. Some methods devised to augment the natural healing response stimulate some regeneration,…”
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A novel serum-free medium for the expansion of human mesenchymal stem cells by Chase, Lucas G, Lakshmipathy, Uma, Solchaga, Luis A, Rao, Mahendra S, Vemuri, Mohan C

“…Human multipotent mesenchymal stem cell (MSC) therapies are being tested clinically for a variety of disorders, including Crohn's disease, multiple sclerosis,…”
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Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor by Lennon, Donald, Solchaga, Luis A, Somoza, Rodrigo A, Schluchter, Mark D, Margevicius, Seunghee, Caplan, Arnold I

“…Tissue engineering requires large numbers of cells with enhanced differentiation properties. Thus, the effect of expansion conditions must be explored. Human…”
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A rapid seeding technique for the assembly of large cell/scaffold composite constructs by Solchaga, Luis A, Tognana, Enrico, Penick, Kitsie, Baskaran, Harihara, Goldberg, Victor M, Caplan, Arnold I, Welter, Jean F

“…These studies address critical technical issues involved in creating human mesenchymal stem cell (hMSC)/ scaffold implants for cartilage repair. These issues…”
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Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds by Solchaga, Luis A., Temenoff, Johnna S., Gao, Jizong, Mikos, Antonios G., Caplan, Arnold I., Goldberg, Victor M.

“…The natural repair of osteochondral defects can be enhanced with biocompatible, biodegradable materials that support the repair process. It is our hypothesis…”
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Augment bone graft products compare favorably with autologous bone graft in an ovine model of lumbar interbody spine fusion by Solchaga, Luis A, Hee, Christopher K, Aguiar, Dean J, Ratliff, Jack, Turner, A Simon, Seim, 3rd, Howard B, Hollinger, Jeffrey O, Snel, Leo B, Lynch, Samuel E

“…This study was designed to determine whether Augment Bone Graft (Augment, Biomimetic Therapeutics, Inc., Franklin, TN) and Augment Injectable Bone Graft…”
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