Search Results - "Solberg, Leah C"

Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder by Fitzpatrick, Mackenzie, Solberg Woods, Leah C

“…Obesity and major depressive disorder (MDD) are both significant health issues that have been increasing in prevalence and are associated with multiple…”
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Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces by Nagpal, Ravinder, Wang, Shaohua, Solberg Woods, Leah C, Seshie, Osborne, Chung, Stephanie T, Shively, Carol A, Register, Thomas C, Craft, Suzanne, McClain, Donald A, Yadav, Hariom

“…Gut microbiome plays a fundamental role in several aspects of host health and diseases. There has been an exponential surge in the use of animal models that…”
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Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections by Bukowy, John D, Dayton, Alex, Cloutier, Dustin, Manis, Anna D, Staruschenko, Alexander, Lombard, Julian H, Solberg Woods, Leah C, Beard, Daniel A, Cowley, Jr, Allen W

“…Histologic examination of fixed renal tissue is widely used to assess morphology and the progression of disease. Commonly reported metrics include glomerular…”
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Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA–GABA transmission in highly addicted rats by Kallupi, Marsida, Carrette, Lieselot L. G., Kononoff, Jenni, Woods, Leah C. Solberg, Palmer, Abraham A., Schweitzer, Paul, George, Olivier, de Guglielmo, Giordano

“…Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the…”
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The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats by Munro, Daniel, Wang, Tengfei, Chitre, Apurva S, Polesskaya, Oksana, Ehsan, Nava, Gao, Jianjun, Gusev, Alexander, Woods, Leah C Solberg, Saba, Laura M, Chen, Hao, Palmer, Abraham A, Mohammadi, Pejman

“…Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological…”
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QTL mapping in outbred populations: successes and challenges by Solberg Woods, Leah C

“…Quantitative trait locus (QTL) mapping in animal populations has been a successful strategy for identifying genomic regions that play a role in complex…”
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Genome‐Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose by Chitre, Apurva S., Polesskaya, Oksana, Holl, Katie, Gao, Jianjun, Cheng, Riyan, Bimschleger, Hannah, Garcia Martinez, Angel, George, Tony, Gileta, Alexander F., Han, Wenyan, Horvath, Aidan, Hughson, Alesa, Ishiwari, Keita, King, Christopher P., Lamparelli, Alexander, Versaggi, Cassandra L., Martin, Connor, St. Pierre, Celine L., Tripi, Jordan A., Wang, Tengfei, Chen, Hao, Flagel, Shelly B., Meyer, Paul, Richards, Jerry, Robinson, Terry E., Palmer, Abraham A., Solberg Woods, Leah C.

“…Objective Obesity is influenced by genetic and environmental factors. Despite the success of human genome‐wide association studies, the specific genes that…”
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The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats by Campus, Paolo, Covelo, Ignacio R, Kim, Youngsoo, Parsegian, Aram, Kuhn, Brittany N, Lopez, Sofia A, Neumaier, John F, Ferguson, Susan M, Solberg Woods, Leah C, Sarter, Martin, Flagel, Shelly B

“…Cues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture…”
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Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats by Hong-Le, Thu, Crouse, Wesley L, Keele, Gregory R, Holl, Katie, Seshie, Osborne, Tschannen, Michael, Craddock, Ann, Das, Swapan K, Szalanczy, Alexandria M, McDonald, Bailey, Grzybowski, Michael, Klotz, Jason, Sharma, Neeraj K, Geurts, Aron M, Key, Chia-Chi Chuang, Hawkins, Gregory, Valdar, William, Mott, Richard, Solberg Woods, Leah C

“…Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous…”
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Genetic Fine‐Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats by Keele, Gregory R., Prokop, Jeremy W., He, Hong, Holl, Katie, Littrell, John, Deal, Aaron, Francic, Sanja, Cui, Leilei, Gatti, Daniel M., Broman, Karl W., Tschannen, Michael, Tsaih, Shirng‐Wern, Zagloul, Maie, Kim, Yunjung, Baur, Brittany, Fox, Joseph, Robinson, Melanie, Levy, Shawn, Flister, Michael J., Mott, Richard, Valdar, William, Solberg Woods, Leah C.

“…Objective Obesity is a major risk factor for multiple diseases and is in part heritable, yet the majority of causative genetic variants that drive excessive…”
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Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3 by Szalanczy, Alexandria M, Giorgio, Gina, Goff, Emily, Seshie, Osborne, Grzybowski, Michael, Klotz, Jason, Geurts, Aron M, Redei, Eva E, Solberg Woods, Leah C

“…We previously identified keratinocyte-associated protein 3, , as an obesity-related gene in female rats where a whole body knockout (KO) led to increased…”
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Incentive salience attribution, “sensation-seeking” and “novelty-seeking” are independent traits in a large sample of male and female heterogeneous stock rats by Hughson, Alesa R., Horvath, Aidan P., Holl, Katie, Palmer, Abraham A., Solberg Woods, Leah C., Robinson, Terry E., Flagel, Shelly B.

“…There are a number of traits that are thought to increase susceptibility to addiction, and some of these are modeled in preclinical studies. For example,…”
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Individual variation in the propensity to attribute incentive salience to a food cue: Influence of sex by Pitchers, Kyle K., Flagel, Shelly B., O’Donnell, Elizabeth G., Solberg Woods, Leah C., Sarter, Martin, Robinson, Terry E.

“…•Two different outbred strains: Sprague-Dawley and Heterogeneous Stock.•Motivational value of the cue was assessed by two measures.•Female SD rats acquired PCA…”
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Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity by Crouse, Wesley L, Das, Swapan K, Le, Thu, Keele, Gregory, Holl, Katie, Seshie, Osborne, Craddock, Ann L, Sharma, Neeraj K, Comeau, Mary E, Langefeld, Carl D, Hawkins, Gregory A, Mott, Richard, Valdar, William, Solberg Woods, Leah C

“…Transcriptomic analysis in metabolically active tissues allows a systems genetics approach to identify causal genes and networks involved in metabolic disease…”
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Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model by Keele, Gregory R., Prokop, Jeremy W., He, Hong, Holl, Katie, Littrell, John, Deal, Aaron W., Kim, Yunjung, Kyle, Patrick B., Attipoe, Esinam, Johnson, Ashley C., Uhl, Katie L., Sirpilla, Olivia L., Jahanbakhsh, Seyedehameneh, Robinson, Melanie, Levy, Shawn, Valdar, William, Garrett, Michael R., Solberg Woods, Leah C.

“…Chronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome…”
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Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats by King, Christopher P., Tripi, Jordan A., Hughson, Alesa R., Horvath, Aidan P., Lamparelli, Alexander C., Holl, Katie L., Chitre, Apurva S., Polesskaya, Oksana, Ishiwari, Keita, Solberg Woods, Leah C., Palmer, Abraham A., Robinson, Terry E., Flagel, Shelly B., Meyer, Paul J.

“…Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that…”
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Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats by King, Christopher P., Palmer, Abraham A., Woods, Leah C. Solberg, Hawk, Larry W., Richards, Jerry B., Meyer, Paul J.

“…Rationale Disorders of behavioral regulation, including attention deficit hyperactivity disorder (ADHD) and drug addiction, are in part due to poor inhibitory…”
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Genome-wide genetic association of complex traits in heterogeneous stock mice by Mott, Richard, Flint, Jonathan, Valdar, William, Solberg, Leah C, Gauguier, Dominique, Burnett, Stephanie, Klenerman, Paul, Cookson, William O, Taylor, Martin S, Rawlins, J Nicholas P

“…Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we…”
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Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics by Parker, Clarissa C., Chen, Hao, Flagel, Shelly B., Geurts, Aron M., Richards, Jerry B., Robinson, Terry E., Solberg Woods, Leah C., Palmer, Abraham A.

“…Due in part to their rich behavioral repertoire rats have been widely used in behavioral studies of drug abuse-related traits for decades. However, the mouse…”
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Heterogeneous Stock Populations for Analysis of Complex Traits by Woods, Leah C Solberg, Mott, Richard

“…Heterogeneous Stock (HS) populations allow for fine-resolution genetic mapping of a variety of complex traits. HS mice and rats were created from breeding…”
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