Antioxidant and anti-proliferative activity of free, conjugates and bound phenolic compounds from tomato and industrial tomato by-product

Antioxidant and anti-proliferative activity of free, conjugates and bound phenolic compounds from tomato and industrial tomato by-product

The aim of this study was to evaluate the antioxidant and anti-proliferative activity of different fractions of phenolic compounds from tomato and tomato by-product. Soluble free phenolics and bound phenolics (BP) fractions from saladette tomato and industrial tomato by-product as well as, conjugate...

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Bibliographic Details
Published in:Journal of food science and technology Vol. 59; no. 6; pp. 2361 - 2369
Main Authors: Perea-Domínguez, Xiomara Patricia, Mendoza-Espinoza, José Alberto, Solano González, Jesús Martin, Leyva-Morales, José Belisario, Espinosa-Alonso, Laura Gabriela, Valdez-Morales, Maribel
Format: Journal Article
Language:English
Published: New Delhi Springer India 01-06-2022
Springer Nature B.V
Subjects:
Anions
Antioxidants
Antiproliferatives
Breast cancer
Byproducts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cytotoxicity
Food Science
Grapes
Hydroxyl radicals
Myoglobins
NADH
Nicotinamide adenine dinucleotide
Nutrition
Original
Original Article
Oxidation
Phenolic compounds
Phenols
Scavenging
Superoxide anions
Tomatoes
Toxicity
Antioxidant capacity
Superoxide anion
Tomato by-product
MCF-7 cell line
Phenolic compounds
Myoglobin protection
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Summary:The aim of this study was to evaluate the antioxidant and anti-proliferative activity of different fractions of phenolic compounds from tomato and tomato by-product. Soluble free phenolics and bound phenolics (BP) fractions from saladette tomato and industrial tomato by-product as well as, conjugated acid-hydrolysable phenolics (AHP) and alkaline-hydrolysable phenolics (AKHP) from saladette tomato, grape tomato and industrial tomato by-product, were tested. The scavenging effects of phenolic fractions on superoxide anion were determined using the PMS-NADH-NBT system. The myoglobin protection ratios of samples against hydroxyl radical were evaluated and the anti-proliferative effects in the MCF-7 breast cancer cell line were determined. AHP fraction from tomato by-product and AKHP fraction from grape and saladette tomato showed the highest inhibitory capacity of the superoxide anion ( p ≤ 0.05). All samples had a myoglobin protection ratio from 30 to 50%. Regarding to cytotoxicity assays, all phenolic fractions from tomato by-product, as well as, BP, AHP, AKHP from saladette tomato and AHP from grape tomato showed important anti-proliferative activity against MCF-7 breast cancer cell line (IC 50 < 20 μg/mL). From the results, we can conclude that tomato and tomato by-product are a good source of natural compound with important antioxidant and anti-proliferative activity.
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ISSN:0022-1155
0975-8402
DOI:10.1007/s13197-021-05252-9