Search Results - "Sokolov, Nikolay N."

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions by Pokrovskaya, Marina V, Pokrovsky, Vadim S, Aleksandrova, Svetlana S, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different…”
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Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from Rhodospirillum rubrum by Conjugation with Chitosan-Based Cationic Polyelectrolytes by Dobryakova, Natalia V, Zhdanov, Dmitry D, Sokolov, Nikolay N, Aleksandrova, Svetlana S, Pokrovskaya, Marina V, Kudryashova, Elena V

“…L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from (RrA) has a…”
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Correction: Plyasova et al. Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase. Pharmaceuticals 2020, 13 , 286 by Plyasova, Anna A, Pokrovskaya, Marina V, Lisitsyna, Olga M, Pokrovsky, Vadim S, Alexandrova, Svetlana S, Hilal, Abdullah, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…In the original publication [...]…”
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Rhodospirillum rubrum L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of Leukemia by Dobryakova, Natalia V., Zhdanov, Dmitry D., Sokolov, Nikolay N., Aleksandrova, Svetlana S., Pokrovskaya, Marina V., Kudryashova, Elena V.

“…L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic…”
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Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase by Plyasova, Anna A, Pokrovskaya, Marina V, Lisitsyna, Olga M, Pokrovsky, Vadim S, Alexandrova, Svetlana S, Hilal, Abdullah, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell…”
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FTIR-based L-asparaginase activity assay enables continuous measurements in optically dense media including blood plasma by Kudryashova, Elena V., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Vinogradov, Alexander A., Sokolov, Nikolay N.

“…Complex heterogeneous systems, such as micelles or blood plasma, represent a particularly challenging environment to measure the catalytic parameters of some…”
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Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase–Carbonic Anhydrase Dual-Hybrid Inhibitors by Plyasova, Anna A, Berrino, Emanuela, Khan, Irina I, Veselovsky, Alexander V, Pokrovsky, Vadim S, Angeli, Andrea, Ferraroni, Marta, Supuran, Claudiu T, Pokrovskaya, Marina V, Alexandrova, Svetlana S, Gladilina, Yulia A, Sokolov, Nikolay N, Hilal, Abdullah, Carta, Fabrizio, Zhdanov, Dmitry D

“…Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3′ ends of chromosomes…”
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Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of human CD4+ T lymphocytes by Zhdanov, Dmitry D., Plyasova, Anna A., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Lobaeva, Tatiana A., Sokolov, Nikolay N.

“…Telomerase activity is regulated at the mRNA level by alternative splicing (AS) of its catalytic subunit hTERT. The aim of this study was to define the ability…”
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Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of normal human CD4+ T-lymphocytes by Zhdanov, Dmitry D., Plyasova, Anna A., Pokrovsky, Vadim S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Gladilina, Yulia A., Sokolov, Nikolay N.

“…The nuclease activity of deoxyribonuclease 1 (DNase I) is regulated by alternative splicing (AS) of its mRNA. The aim of this study was to define the ability…”
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Murine regulatory T cells induce death of effector T, B, and NK lymphocytes through a contact-independent mechanism involving telomerase suppression and telomere-associated senescence by Zhdanov, Dmitry D., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Sokolov, Nikolay N.

“…•Tregs induce death of effector lymphocytes through a contact-independent mechanism.•The death of effector cells is promoted by telomere-dependent…”
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Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis by Zhdanov, Dmitry D., Gladilina, Yulia A., Pokrovsky, Vadim S., Grishin, Dmitry V., Grachev, Vladimir A., Orlova, Valentina S., Pokrovskaya, Marina V., Alexandrova, Svetlana S., Plyasova, Anna A., Sokolov, Nikolay N.

“…Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential…”
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Structural and functional insights into Erwinia carotovora l-asparaginase by Papageorgiou, Anastassios C, Posypanova, Galina A, Andersson, Charlotta S, Sokolov, Nikolay N, Krasotkina, Julya

“…Bacterial l-asparaginases are enzymes that catalyze the hydrolysis of l-asparagine to aspartic acid. For the past 30 years, these enzymes have been used as…”
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One-step purification and kinetic properties of the recombinant l-asparaginase from Erwinia carotovora by Krasotkina, Julya, Borisova, Anna A., Gervaziev, Yuri V., Sokolov, Nikolay N.

“…ECAR‐LANS, the recombinant l‐asparaginase from Erwinia carotovora, is a prospective therapeutic enzyme for leukaemia treatment. An efficient and economical…”
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IRhodospirillum rubrum/I L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of Leukemia by Dobryakova, Natalia V, Zhdanov, Dmitry D, Sokolov, Nikolay N, Aleksandrova, Svetlana S, Pokrovskaya, Marina V, Kudryashova, Elena V

“…L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic…”
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Crystallization and preliminary crystallographic analysis of l-asparaginase from Erwinia carotovora by Wikman, Linnea E. K., Krasotkina, Julya, Kuchumova, Anastasia, Sokolov, Nikolay N., Papageorgiou, Anastassios C.

“…Bacterial l‐asparaginases have been used as therapeutic agents in the treatment of acute childhood lymphoblastic leukaemia for over 30 y. However, their use is…”
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Structural and functional insights into Erwiniacarotovoral-asparaginase by Papageorgiou, Anastassios C, Posypanova, Galina A, Andersson, Charlotta S, Sokolov, Nikolay N, Krasotkina, Julya

“…Bacterial l-asparaginases are enzymes that catalyze the hydrolysis of l-asparagine to aspartic acid. For the past 30years, these enzymes have been used as…”
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One-step purification and kinetic properties of the recombinant L-asparaginase from Erwinia carotovora by KRASOTKINA, Julya, BORISOVA, Anna A, GERVAZIEV, Yuri V, SOKOLOV, Nikolay N

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