Search Results - "Sokol, Nicholas S."

Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function by Chawla, Geetanjali, Sokol, Nicholas S

“…Steroid hormones and their nuclear receptors drive developmental transitions in diverse organisms, including mammals. In this study, we show that the…”
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Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth by Sokol, Nicholas S, Ambros, Victor

“…Although hundreds of evolutionarily conserved microRNAs have been discovered, the functions of most remain unknown. Here, we describe the embryonic…”
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let-7-Complex MicroRNAs Regulate the Temporal Identity of Drosophila Mushroom Body Neurons via chinmo by Wu, Yen-Chi, Chen, Ching-Huan, Mercer, Adam, Sokol, Nicholas S.

“…Many neural lineages display a temporal pattern, but the mechanisms controlling the ordered production of neuronal subtypes remain unclear. Here, we show that…”
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Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis by Sokol, Nicholas S, Xu, Peizhang, Jan, Yuh-Nung, Ambros, Victor

“…The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the…”
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Canonical nucleators are dispensable for stress granule assembly in Drosophila intestinal progenitors by Buddika, Kasun, Ariyapala, Ishara S, Hazuga, Mary A, Riffert, Derek, Sokol, Nicholas S

“…Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Although SGs have been extensively…”
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A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila by Chawla, Geetanjali, Deosthale, Padmini, Childress, Sue, Wu, Yen-Chi, Sokol, Nicholas S

“…Messenger RNAs (mRNAs) often contain binding sites for multiple, different microRNAs (miRNAs). However, the biological significance of this feature is unclear,…”
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Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity by Buddika, Kasun, Huang, Yi-Ting, Ariyapala, Ishara S., Butrum-Griffith, Alex, Norrell, Sam A., O’Connor, Alex M., Patel, Viraj K., Rector, Samuel A., Slovan, Mark, Sokolowski, Mallory, Kato, Yasuko, Nakamura, Akira, Sokol, Nicholas S.

“…The role of processing bodies (P-bodies), key sites of post-transcriptional control, in adult stem cells remains poorly understood. Here, we report that adult…”
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Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development by Li, Hongde, Rai, Madhulika, Buddika, Kasun, Sterrett, Maria C, Luhur, Arthur, Mahmoudzadeh, Nader H, Julick, Cole R, Pletcher, Rose C, Chawla, Geetanjali, Gosney, Chelsea J, Burton, Anna K, Karty, Jonathan A, Montooth, Kristi L, Sokol, Nicholas S, Tennessen, Jason M

“…The dramatic growth that occurs during larval development requires rapid conversion of nutrients into biomass. Many larval tissues respond to these…”
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Molecular Dissection of a Conserved Cluster of miRNAs Identifies Critical Structural Determinants That Mediate Differential Processing by Pandey, Manish, Luhur, Arthur, Sokol, Nicholas S, Chawla, Geetanjali

“…Differential processing is a hallmark of clustered microRNAs (miRNAs) and the role of position and order of miRNAs in a cluster together with the contribution…”
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miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila by Pandey, Manish, Bansal, Sakshi, Bar, Sudipta, Yadav, Amit Kumar, Sokol, Nicholas S, Tennessen, Jason M, Kapahi, Pankaj, Chawla, Geetanjali

“…Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their…”
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The Role of MicroRNAs in Muscle Development by Sokol, Nicholas S.

“…MicroRNAs play essential roles during animal development, including in developing muscle. Many microRNAs are expressed during muscle development and some, like…”
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Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis by Luhur, Arthur, Chawla, Geetanjali, Wu, Yen-Chi, Li, Jing, Sokol, Nicholas S.

“…Cleavage of microRNAs and mRNAs by Drosha and its cofactor Pasha/DGCR8 is required for animal development, but whether these proteins also have independent…”
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Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila by Narbonne-Reveau, Karine, Lanet, Elodie, Dillard, Caroline, Foppolo, Sophie, Chen, Ching-Huan, Parrinello, Hugues, Rialle, Stéphanie, Sokol, Nicholas S, Maurange, Cédric

“…Pediatric neural tumors are often initiated during early development and can undergo very rapid transformation. However, the molecular basis of this early…”
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Identification and Characterization of Breakpoints and Mutations on Drosophila melanogaster Balancer Chromosomes by Miller, Danny E, Kahsai, Lily, Buddika, Kasun, Dixon, Michael J, Kim, Bernard Y, Calvi, Brian R, Sokol, Nicholas S, Hawley, R Scott, Cook, Kevin R

“…Abstract Balancers are rearranged chromosomes used in Drosophila melanogaster to maintain deleterious mutations in stable populations, preserve sets of linked…”
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Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity by Sempere, Lorenzo F, Sokol, Nicholas S, Dubrovsky, Edward B, Berger, Edward M, Ambros, Victor

“…lin-4 and let-7 are founding members of an extensive family of genes that produce small transcripts, termed microRNAs (miRNAs). In Caenorhabditis elegans,…”
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A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis by Mukherjee, Sromana, Paricio, Nuria, Sokol, Nicholas S.

“…Adult organisms must sense and adapt to environmental fluctuations. In high-turnover tissues such as the intestine, these adaptive responses require rapid…”
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Small temporal RNAs in animal development by Sokol, Nicholas S

“…The lin-4 / miR-125 and let-7 microRNAs are at the heart of the heterochronic pathway, which controls temporal cell fate determination during Caenorhabditis…”
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I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells by Buddika, Kasun, Xu, Jingjing, Ariyapala, Ishara S, Sokol, Nicholas S

“…The adult intestinal epithelium is a model system for stem cell biology, but its utility is limited by current biochemical methods that lack cell type…”
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ADAR mediates differential expression of polycistronic microRNAs by Chawla, Geetanjali, Sokol, Nicholas S.

“…Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural…”
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MicroRNA mediated regulation of the onset of enteroblast differentiation in the Drosophila adult intestine by Mukherjee, Sromana, Calvi, Brian R., Hundley, Heather A., Sokol, Nicholas S.

“…Somatic adult stem cell lineages in high-turnover tissues are under tight gene regulatory control. Like its mammalian counterpart, the Drosophila intestine…”
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