Search Results - "Soko, D"

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control by HIGGINS, Guy A, SILENIEKS, Leo B, ROSSMANN, Anne, RIZOS, Zoe, NOBLE, Kevin, SOKO, Ashlie D, FLETCHER, Paul J

“…Lorcaserin ((1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine HCl) is a selective 5-HT(2C) receptor agonist with clinical efficacy in phase-III…”
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Impulsive action in the 5-choice serial reaction time test in 5-HT2C receptor null mutant mice by Fletcher, Paul J., Soko, Ashlie D., Higgins, Guy A.

“…Rationale Depletion of brain serotonin (5-HT) results in impulsive behaviour as measured by increased premature responding in the five-choice serial reaction…”
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A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics by Soko, Nyarai D, Masimirembwa, Collen, Dandara, Collet

“…This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism SLCO1B1 c.1929A>C in genomic DNA samples. The…”
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Pharmacogenomics of Rosuvastatin: A Glocal (Global+Local) African Perspective and Expert Review on a Statin Drug by Soko, Nyarai D, Masimirembwa, Collen, Dandara, Collet

“…The incidence of cardiovascular diseases (CVDs) in African populations residing in the African continent is on the rise fueled by both a steady increase in CVD…”
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Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans by Katsukunya, Jonathan N., Soko, Nyarai D., Naidoo, Jashira, Rayner, Brian, Blom, Dirk, Sinxadi, Phumla, Chimusa, Emile R., Dandara, Michelle, Dzobo, Kevin, Jones, Erika, Dandara, Collet

“…In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD)…”
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Microbiology of chronic suppurative otitis media at Queen Elizabeth Central Hospital, Blantyre, Malawi: A cross-sectional descriptive study by Chirwa, M, Mulwafu, W, Aswani, J M, Masinde, P W, Mkakosya, R, Soko, D

“…Chronic suppurative otitis media (CSOM) is still a significant health problem in developing countries. Therefore, it was pertinent to determine the local…”
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The COVID-19 Pandemic and Explaining Outcomes in Africa: Could Genomic Variation Add to the Debate? by Soko, Nyarai D, Dlamini, Sipho, Ntsekhe, Mpiko, Dandara, Collet

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, emanated from the Wuhan Province in China and rapidly spread…”
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Priority setting in otolaryngology practices in Zimbabwe by Chidziva, Clemence, Soko, Nyarai D

“…This article describes priority setting in otorhinolaryngology healthcare services in Zimbabwe. It aims to initiate discussion on priority setting among…”
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HIV and AIDS workplace interventions; gaps between policy and practice at the College of Medicine by Soko, D, Umar, E, Noniwa, T, Lakudzala, A

“…This study set out to identify gaps between policy and practice of HIV and AIDS workplace interventions in the University of Malawi, in particular College of…”
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Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release by Zeeb, Fiona D, Soko, Ashlie D, Ji, Xiaodong, Fletcher, Paul J

“…Poor impulse control is associated with an increased propensity to develop an addiction and may contribute to relapse as high impulsive subjects appear to…”
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Bacteraemia and mortality among adult medical admissions in Malawi: Predominance of non-typhi salmonellae and Streptococcus pneumoniae by GORDON, M. A, WALSH, A. L, CHAPONDA, M, SOKO, D, MBVWINJI, M, MOLYNEUX, M. E, GORDON, S. B

“…The high seroprevalence of HIV in Malawi might be expected to alter the pattern of pathogens isolated from bacteraemic patients. We aimed to describe the…”
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Major Genetic Drivers of Statin Treatment Response in African Populations and Pharmacogenetics of Dyslipidemia Through a One Health Lens by Lusiki, Zizo, Blom, Dirk, Soko, Nyarai D, Malema, Smangele, Jones, Erika, Rayner, Brian, Blackburn, Jonathan, Sinxadi, Phumla, Dandara, Michelle T, Dandara, Collet

“…A One Health lens is increasingly significant to address the intertwined challenges in planetary health concerned with the health of humans, nonhuman animals,…”
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Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes by Muyambo, Sarudzai, Ndadza, Arinao, Soko, Nyarai D, Kruger, Bianca, Kadzirange, Gerard, Chimusa, Emile, Masimirembwa, Collen M, Ntsekhe, Mpiko, Nhachi, Charles F B, Dandara, Collet

“…Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet needs further development in resource-limited countries. While there is an…”
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Genetic Variation in ABCB1 , ADRB1 , CYP3A4 , CYP3A5 , NEDD4L and NR3C2 Confers Differential Susceptibility to Resistant Hypertension among South Africans by Katsukunya, Jonathan N, Jones, Erika, Soko, Nyarai D, Blom, Dirk, Sinxadi, Phumla, Rayner, Brian, Dandara, Collet

“…Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role of genetic variation on RHTN among Africans. We…”
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Aetiology of neonatal sepsis in Blantyre, Malawi: 1996-2001 by Milledge, J., Calis, J. C. J., Graham, S. M., Phiri, A., Wilson, L. K., Soko, D., Mbvwinji, M., Walsh, A. L., Rogerson, S. R., Molyneux, E. M.

“…Aim: The aim of this retrospective study was to report causes, antibiotic resistance and outcome of neonatal sepsis (often fatal in developing countries) in…”
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Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement by Fletcher, Paul J., Rizos, Zoë, Noble, Kevin, Soko, Ashlie D., Silenieks, Leo B., Lê, Anh Dzung, Higgins, Guy A.

“…The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT2A and 5-HT2C receptors, modulates dopamine…”
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Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate by Fletcher, Paul J., Zeeb, Fiona D., Browne, Caleb J., Higgins, Guy A., Soko, Ashlie D.

“…Objectives These experiments examined the effects of selective 5-HT 1A , 5-HT 2A and 5-HT 2C receptor ligands on responding for a conditioned reinforcer (CRf)…”
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Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe by Matinhira, Naboth, Soko, Nyarai D., Bandason, Tsitsi, Jenson, Ramon G., Dzongodza, Titus, von Buchwald, Christian, Chidziva, Clemence

“…Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent…”
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Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans by Mpeta, Bafokeng, Kampira, Elizabeth, Castel, Sandra, Mpye, Keleabetswe L, Soko, Nyarai D, Wiesner, Lubbe, Smith, Peter, Skelton, Michelle, Lacerda, Miguel, Dandara, Collet

“…Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants…”
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Responding for conditioned reinforcement in C57BL/6 and CD-1 mice, and Sprague-Dawley rats: Effects of methylphenidate and amphetamine by Browne, J. D. Caleb, Soko, Ashlie D., Fletcher, Paul J.

“…Rationale Characterization of responding for conditioned reinforcement in mice is important to implement genetic tools in examining the neurobiological…”
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