Search Results - "Sokar, Samia"

Combined carvacrol and cilostazol ameliorate ethanol-induced liver fibrosis in rats: Possible role of SIRT1/Nrf2/HO-1 pathway by Abu-Risha, Sally E., Sokar, Samia S., Elbohoty, Heba R., Elsisi, Alaa E.

“…[Display omitted] •Liver fibrosis is one of the most widespread hepatic diseases in the world.•Carvacrol or cilostazol ameliorate alcoholic liver fibrosis…”
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Donepezil and quercetin alleviate valproate-induced testicular oxidative stress, inflammation and apoptosis: Imperative roles of AMPK/SIRT1/ PGC-1α and p38-MAPK/NF-κB/ IL-1β signaling cascades by Abu-Risha, Sally E., Sokar, Samia S., Elzorkany, Kawthar E., Elsisi, Alaa E.

“…•VPA administration negatively impacts the overall testicular function.•Donepezil or quercetin effectively mitigates VPA-induced testicular toxicity.•The…”
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Dexamethasone and losartan combination treatment protected cigarette smoke-induced COPD in rats by Sokar, Samia S, Afify, Esraa H, Osman, Enass Y

“…Chronic Obstructive Pulmonary Disease (COPD) is a dangerous prevalent smoking-related disease characterized by abnormal inflammation and oxidative stress and…”
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Cilostazol protects against gastric ulcers by regulating PPAR-γ, HO-1, PECAM-1, pErk-1, NF-κB, Bcl-2, and cleaved caspase-3 protein expression by El-Shitany, Nagla A., EL-saidy, Eman A., EL-Naggar, Mostafa E., Sokar, Samia S.

“…Millions of individuals worldwide, across all age groups, suffer from the widespread health issue of gastric ulcers. In many experiments, cilostazol (Cls), a…”
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Enhanced anticancer activity of combined treatment of imatinib and dipyridamole in solid Ehrlich carcinoma-bearing mice by El-Sisi, Alaa E., Sokar, Samia S., Ibrahim, Hanaa A., Abu-Risha, Sally E.

“…The current study was designed to evaluate potential enhancement of the anticancer activity of imatinib mesylate (IM) with dipyridamole (DIP) and to…”
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Oxamate potentiates taxol chemotherapeutic efficacy in experimentally-induced solid ehrlich carcinoma (SEC) in mice by El-Sisi, Alaa E., Sokar, Samia S., Abu-Risha, Sally E., El-Mahrouk, Sara R.

“…Several human cancers including the breast display elevated expression of Lactate dehydrogenase-A (LDH-A), the enzyme that converts pyruvate to lactate and…”
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Combination of tadalafil and diltiazem attenuates renal ischemia reperfusion-induced acute renal failure in rats by El-Sisi, Alaa E, Sokar, Samia S, Abu-Risha, Sally E, Ibrahim, Hanaa A

“…Abstract Life threatening conditions characterized by renal ischemia/reperfusion (RIR) such as kidney transplantation, partial nephrectomy, renal artery…”
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The potential beneficial effects of sildenafil and diosmin in experimentally-induced gastric ulcer in rats by El-Sisi, Alaa E., Sokar, Samia S., Abu-Risha, Sally E., Khira, Doaa Y.

“…research in the treatment of gastric ulcer has involved the investigation of protective drugs. These drugs may be used as adjacent therapy with the traditional…”
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Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats by Salem Sokar, Samia, Elsayed Elsayad, Mageda, Sabri Ali, Hend

“…Research in the treatment of gastric ulcer has involved the investigation of new alternatives, such as anti-depressant drugs. The present study was designed to…”
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PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone by El-Sisi, Alaa E, Sokar, Samia S, Salem, Tarek A, Abu Risha, Sally E

“…Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess…”
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Role of cysteinyl leukotriene receptor-1 antagonists in treatment of experimentally induced mammary tumor: Does montelukast modulate antitumor and immunosuppressant effects of doxorubicin? by El-Sisi, Alaa El-Din E, Sokar, Samia S, Salem, Tarek A, Abu Risha, Sally E

“…It has been reported that a leukotriene (LT)-D4 receptor (i.e. cysteinyl LT1 receptor; CysLT1R) has an important role in carcinogenesis. The current study was…”
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Targeting SRD5A1 and MMP-2/NLRP3/TGF-β1 axis alleviates the amlodipine-induced gingival hyperplasia in rats: Emerging role of saw palmetto and folic acid by El Tabaa, Manar Mohammed, Aboud, Mahmoud Moustafa, Anis, Anis, Rashad, Eman, Sokar, Samia Salem

“…Saw palmetto (SAW), the herbal drug used to treat prostatic hyperplasia, exerts its antiproliferative effects by blocking steroid 5 alpha-reductase (SRD5A1)…”
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Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury by El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Mohamed, Dina Zakaria, Abu-Risha, Sally El-Sayed

“…The Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB)/NLRP3 inflammasome signaling pathway is essential in the pathogenesis of hepatic ischemia/…”
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Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats by Mohamed, Dina Zakaria, El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Abu-Risha, Sally El-Sayed

“…Hepatic ischemia-reperfusion (HIR) injury is a common pathophysiological process in many clinical settings. This study was designed to compare the protective…”
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Hepatoprotective effects of carvedilol and crocin against leflunomide-induced liver injury by Sokar, Samia Salem, Alkabbani, Mahmoud Abdelrahman, Akool, El-Sayed, Abu-Risha, Sally El-Sayed

“…•Leflunomide induces liver injury via different mechanisms like TLR4 activation, ER stress, and mitochondrial dysfunction.•The risk of leflunomide-induced…”
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Combination of Sitagliptin and Silymarin ameliorates liver fibrosis induced by carbon tetrachloride in rats by Sokar, Samia Salem, El-Sayad, Magda El-Sayed, Ghoneim, Mai El-Sayed, Shebl, Abdelhadi Mohamed

“…Abstract Liver fibrosis is a common pathological condition that occurs in most conditions associated with chronic liver injury. Silymarin is a herbal product…”
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Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4 - induced liver fibrosis in mice by Elmahdy, Nageh Ahmed, Sokar, Samia Salem, Salem, Mohamed Labib, Sarhan, Naglaa Ibrahim, Abou-Elela, Sherin Hamed

“…Abstract Liver fibrosis is the consequence of hepatocyte injury that leads to the activation of hepatic stellate cells (HSC). The treatment of choice is Liver…”
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Antifibrotic effect of diethylcarbamazine combined with hesperidin against ethanol induced liver fibrosis in rats by El-Sisi, Alaa El-Din El-Sayed, Sokar, Samia Salim, Shebl, Abdelhadi Mohamed, Mohamed, Dina Zakaria

“…Abstract Chronic alcohol consumption leads to extracellular matrix hyperplasia and liver fibrosis with a great role of hepatic stellate cell (HSC) activation…”
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Metformin potentiates the chemotherapeutic effects of doxorubicin on 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5b] pyridine‐induced Mammary Carcinoma in rats by Salim, Elsayed, El‐Sisi, Alaa El‐Din, Sokar, Samia, EL‐Sayad, Magda, Moussa, Ethar

“…This study was carried out to evaluate the antitumor activity of Metformin (Met) and its impending utility to potentiate the chemotherapeutic action of…”
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Poster #M236 THE POTENTIAL BENEFICIAL EFFECTS OF CELECOXIB OR OMEGA-3 AS ADJUVANT THERAPY IN SCHIZOPHRENIA INDUCED IN EXPERIMENTAL ANIMALS by Osman, Enass Y, Elsisy, Alaa ElDin, Sokar, Samia, Elsayad, Magda, Ramadan, Ehab

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