Search Results - "Soifer, S J"

Thrombin receptor expression in normal and atherosclerotic human arteries by NELKEN, N. A, SOIFER, S. J, O'KEEFE, J, VU, T.-K. H, CHARO, I. F, COUGHLIN, S. R

“…Thrombin is a multifunctional serine protease generated at sites of vascular injury. A host of thrombin actions on vascular endothelial cells, smooth muscle…”
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N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs by Fineman, J R, Heymann, M A, Soifer, S J

“…To investigate the role of endothelium-derived relaxing factor (EDRF) in the regulation of resting pulmonary vascular tone and endothelium-dependent pulmonary…”
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Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs by BLACK, S. M, JOHENGEN, M. J, SOIFER, S. J

“…Ligation of the ductus arteriosus in utero produces fetal and neonatal pulmonary hypertension and alterations in the hemodynamic responses to nitric oxide and…”
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Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension by BLACK, S. M, BEKKER, J. M, JOHENGEN, M. J, PARRY, A. J, SOIFER, S. J, FINEMAN, J. R

“…Plasma concentrations of endothelin-1 (ET-1) are increased in children with congenital heart disease associated with increased pulmonary blood flow. However,…”
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Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb by Wong, J, Vanderford, P A, Fineman, J R, Chang, R, Soifer, S J

“…The vascular endothelium mediates, in part, pulmonary vascular tone. Because endothelin-1 (ET-1), a paracrine hormone produced by vascular endothelial cells,…”
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EDRF inhibition augments pulmonary hypertension in intact newborn lambs by Fineman, J R, Chang, R, Soifer, S J

“…There is increasing evidence that resting pulmonary vascular tone is mediated by the release of endothelium-derived relaxing factors (EDRF). However, the…”
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Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development by Soifer, SJ, Peters, KG, O'Keefe, J, Coughlin, SR

“…The protease thrombin is a potent agonist for platelet aggregation, mesenchymal cell proliferation, and endothelial production of growth factors and adhesion…”
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EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs by Moore, P, Velvis, H, Fineman, J R, Soifer, S J, Heymann, M A

“…At birth, pulmonary vasodilation occurs during rhythmic distension of the lungs and oxygenation. Inhibition of prostaglandin synthesis prevents pulmonary…”
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L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs by Fineman, J R, Chang, R, Soifer, S J

“…There is increasing evidence that resting pulmonary vascular tone is mediated in part by the release of endothelium-derived relaxing factors (EDRF). Because…”
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K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide by Chang, J K, Moore, P, Fineman, J R, Soifer, S J, Heymann, M A

“…To define the role and mechanism of action of K+ channels in regulating fetal pulmonary vascular tone, we studied the hemodynamic effects of pinacidil (a K+…”
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A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis by QUINN, Timothy P, SOIFER, Scott J, RAMER, Kevin, WILLIAMS, Lewis T, NAKAMURA, Mary C

“…Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates…”
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In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue by Fineman, J R, Crowley, M R, Heymann, M A, Soifer, S J

“…In vitro evidence suggests that resting pulmonary vascular tone and endothelium-dependent pulmonary vasodilation are mediated by changes in vascular smooth…”
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Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb by Wong, J, Vanderford, P A, Winters, J W, Chang, R, Soifer, S J, Fineman, J R

“…The mechanisms by which acute alveolar hypoxia induces pulmonary vasoconstriction remain unclear. Previous studies suggest that hypoxia-induced…”
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Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs by FINEMAN, J. R, WONG, J, SOIFER, S. J

“…Supplemental oxygen and alkalosis are the most effective treatments used to lower pulmonary arterial pressure in children with pulmonary hypertensive…”
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Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects by BROOK, M. M, FINEMAN, J. R, BOLINGER, A. M, WONG, A. F, HEYMANN, M. A, SOIFER, S. J

“…Pulmonary hypertension results in increased morbidity and mortality in children after surgical repair of congenital heart defects. Various vasodilators have…”
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Developmental effects of endothelin-1 on the pulmonary circulation in sheep by WONG, J, VANDERFORD, P. A, FINEMAN, J. R, SOIFER, S. J

“…Endothelin-1 (ET-1) is a polypeptide that has potent hemodynamic effects on the pulmonary circulation. To determine whether there are changes in these effects…”
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Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs by Fineman, J R, Crowley, M R, Soifer, S J

“…We investigated the effects of infusions of ATP-MgCl2 on the circulation in 11 spontaneously breathing newborn lambs during pulmonary hypertension induced…”
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Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs by Soifer, S J, Loitz, R D, Roman, C, Heymann, M A

“…The factors responsible for maintaining the normally low pulmonary blood flow and high pulmonary vascular resistance in the fetus are not well understood…”
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Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production by Frantz, E, Soifer, S J, Clyman, R I, Heymann, M A

“…Bradykinin produces pulmonary vasodilation and also stimulates production of other pulmonary vasodilators, including prostaglandin I2 (PGI2) and…”
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Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension by Black, S M, Fineman, J R, Steinhorn, R H, Bristow, J, Soifer, S J

“…Altered pulmonary vascular reactivity is a source of morbidity and mortality for children with congenital heart defects and increased pulmonary blood flow…”
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