Search Results - "Sohr, Reinhard"

Growth retardation and altered autonomic control in mice lacking brain serotonin by Alenina, Natalia, Kikic, Dana, Todiras, Mihail, Mosienko, Valentina, Qadri, Fatimunnisa, Plehm, Ralph, Boyé, Philipp, Vilianovitch, Larissa, Sohr, Reinhard, Tenner, Katja, Hörtnagl, Heide, Bader, Michael

“…Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2⁻/⁻)…”
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Exofocal Dopaminergic Degeneration as Antidepressant Target in Mouse Model of Poststroke Depression by Kronenberg, Golo, Balkaya, Mustafa, Prinz, Vincent, Gertz, Karen, Ji, Shengbo, Kirste, Imke, Heuser, Isabella, Kampmann, Björn, Hellmann-Regen, Julian, Gass, Peter, Sohr, Reinhard, Hellweg, Rainer, Waeber, Christian, Juckel, Georg, Hörtnagl, Heide, Stumm, Ralf, Endres, Matthias

“…Background Although poststroke depression (PSD) is a frequent chronic complication of stroke with high relevance for outcome and survival, underlying…”
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Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: Implications for genesis of neurodevelopmental disorders by Fatemi, S. Hossein, Reutiman, Teri J, Folsom, Timothy D, Huang, Hao, Oishi, Kenichi, Mori, Susumu, Smee, Donald F, Pearce, David A, Winter, Christine, Sohr, Reinhard, Juckel, Georg

“…Abstract Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection…”
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The Role of the Striatum in Compulsive Behavior in Intact and Orbitofrontal-Cortex-Lesioned Rats: Possible Involvement of the Serotonergic System by SCHILMAN, Eduardo A, KLAVIR, Oded, WINTER, Christine, SOHR, Reinhard, JOEL, Daphna

“…In the signal attenuation rat model of obsessive-compulsive disorder (OCD), 'compulsive' behavior is induced by attenuating a signal indicating that a…”
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Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans by Albert, Frank W., Shchepina, Olesya, Winter, Christine, Römpler, Holger, Teupser, Daniel, Palme, Rupert, Ceglarek, Uta, Kratzsch, Jürgen, Sohr, Reinhard, Trut, Lyudmila N., Thiery, Joachim, Morgenstern, Rudolf, Plyusnina, Irina Z., Schöneberg, Torsten, Pääbo, Svante

“…To better understand the biology of tameness, i.e. tolerance of human presence and handling, we analyzed two lines of wild-derived rats ( Rattus norvegicus)…”
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Folate Deficiency Induces Neurodegeneration and Brain Dysfunction in Mice Lacking Uracil DNA Glycosylase by Kronenberg, Golo, Harms, Christoph, Sobol, Robert W, Cardozo-Pelaez, Fernando, Linhart, Heinz, Winter, Benjamin, Balkaya, Mustafa, Gertz, Karen, Gay, Shanna B, Cox, David, Eckart, Sarah, Ahmadi, Michael, Juckel, Georg, Kempermann, Gerd, Hellweg, Rainer, Sohr, Reinhard, Hortnagl, Heide, Wilson, Samuel H, Jaenisch, Rudolf, Endres, Matthias

“…Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like…”
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Constitutive Genetic Deletion of the Growth Regulator Nogo-A Induces Schizophrenia-Related Endophenotypes by Willi, Roman, Weinmann, Oliver, Winter, Christine, Klein, Julia, Sohr, Reinhard, Schnell, Lisa, Yee, Benjamin K, Feldon, Joram, Schwab, Martin E

“…The membrane protein Nogo-A, which is predominantly expressed by oligodendrocytes in the adult CNS and by neurons mainly during development, is well known for…”
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The role of the subthalamic nucleus in 'compulsive' behavior in rats by Winter, Christine, Flash, Shira, Klavir, Oded, Klein, Julia, Sohr, Reinhard, Joel, Daphna

“…Different lines of evidence point to dysfunction of basal ganglia‐thalamocortical circuits in obsessive‐compulsive disorder (OCD). It has been hypothesized…”
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Anxious and Hyperactive Phenotype Following Brief Ischemic Episodes in Mice by Winter, Benjamin, Juckel, Georg, Viktorov, Ilya, Katchanov, Juri, Gietz, Andrea, Sohr, Reinhard, Balkaya, Mustafa, Hörtnagl, Heide, Endres, Matthias

“…Poststroke emotional and behavioral abnormalities have an impact on outcome but have scarcely been characterized in animal models. We tested whether brief…”
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Impact of Actin Filament Stabilization on Adult Hippocampal and Olfactory Bulb Neurogenesis by Kronenberg, Golo, Gertz, Karen, Baldinger, Tina, Kirste, Imke, Eckart, Sarah, Yildirim, Ferah, Ji, Shengbo, Heuser, Isabella, Schrock, Helmut, Hortnagl, Heide, Sohr, Reinhard, Djoufack, Pierre Chryso, Juttner, Rene, Glass, Rainer, Przesdzing, Ingo, Kumar, Jitender, Freyer, Dorette, Hellweg, Rainer, Kettenmann, Helmut, Fink, Klaus Benno, Endres, Matthias

“…Rearrangement of the actin cytoskeleton is essential for dynamic cellular processes. Decreased actin turnover and rigidity of cytoskeletal structures have been…”
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Identification and Quantitation of the N-Acetyl-L-cysteine S-Conjugates of Bendamustine and Its Sulfoxides in Human Bile after Administration of Bendamustine Hydrochloride by TEICHERT, Jens, SOHR, Reinhard, HENNIG, Lothar, BAUMANN, Frank, SCHOPPMEYER, Konrad, PATZAK, Ulrich, PREISS, Rainer

“…We recently reported the detection of mercapturic acid pathway metabolites of bendamustine, namely, cysteine S -conjugates in human bile, which are supposed to…”
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Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems by Tasaki, Takafumi, Sohr, Reinhard, Xia, Zanxian, Hellweg, Rainer, Hörtnagl, Heide, Varshavsky, Alexander, Kwon, Yong Tae

“…Our previous work identified E3 ubiquitin ligases, termed UBR1-UBR7, that contain the ∼70-residue UBR box, a motif important for the targeting of N-end rule…”
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Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats by Meissner, Wassilios, Harnack, Daniel, Paul, Gesine, Reum, Torsten, Sohr, Reinhard, Morgenstern, Rudolf, Kupsch, Andreas

“…Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson's disease (PD) symptoms. Although widely used, the mechanisms of action are…”
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SYNTHESIS AND CHARACTERIZATION OF SOME NEW PHASE II METABOLITES OF THE ALKYLATOR BENDAMUSTINE AND THEIR IDENTIFICATION IN HUMAN BILE, URINE, AND PLASMA FROM PATIENTS WITH CHOLANGIOCARCINOMA by TEICHERT, Jens, SOHR, Reinhard, BAUMANN, Frank, HENNIG, Lothar, MERKLE, Karlheinz, CACA, Karel, PREISS, Rainer

“…The alkylating agent bendamustine is currently in phase III clinical trials for the treatment of hematological malignancies and breast, lung, and…”
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Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats by Meissner, Wassilios, Reum, Torsten, Paul, Gesine, Harnack, Daniel, Sohr, Reinhard, Morgenstern, Rudolf, Kupsch, Andreas

“…Deep brain stimulation of the subthalamic nucleus is an established therapeutic strategy for patients with Parkinson's disease. Although the exact mechanisms…”
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Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia by Winter, Christine, Djodari-Irani, Anais, Sohr, Reinhard, Morgenstern, Rudolf, Feldon, Joram, Juckel, Georg, Meyer, Urs

“…Maternal infection during pregnancy enhances the offspring's risk for severe neuropsychiatric disorders in later life, including schizophrenia. Recent attempts…”
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Using a maternal immune stimulation model of schizophrenia to study behavioral and neurobiological alterations over the developmental course by Hadar, Ravit, Soto-Montenegro, M Luisa, Götz, Thomas, Wieske, Franziska, Sohr, Reinhard, Desco, Manuel, Hamani, Clement, Weiner, Ina, Pascau, Javier, Winter, Christine

“…Abstract A growing body of evidence sheds light on the neurodevelopmental nature of schizophrenia with symptoms typically emerging during late adolescence or…”
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Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder by Winter, Christine, Greene, Dana M., Mavrogiorgou, Paraskevi, Schaper, Helge, Sohr, Reinhard, Bult-Ito, Abel, Juckel, Georg

“…There is ample evidence that obsessive-compulsive disorder (OCD) is based on reduced serotonergic function. Replicated bidirectional selection for…”
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L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum by Porras, Gregory, De Deurwaerdere, Philippe, Li, Qin, Marti, Matteo, Morgenstern, Rudolf, Sohr, Reinhard, Bezard, Erwan, Morari, Michele, Meissner, Wassilios G.

“…L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID)…”
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A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice by Enard, Wolfgang, Gehre, Sabine, Hammerschmidt, Kurt, Hölter, Sabine M., Blass, Torsten, Somel, Mehmet, Brückner, Martina K., Schreiweis, Christiane, Winter, Christine, Sohr, Reinhard, Becker, Lore, Wiebe, Victor, Nickel, Birgit, Giger, Thomas, Müller, Uwe, Groszer, Matthias, Adler, Thure, Aguilar, Antonio, Bolle, Ines, Calzada-Wack, Julia, Dalke, Claudia, Ehrhardt, Nicole, Favor, Jack, Fuchs, Helmut, Gailus-Durner, Valérie, Hans, Wolfgang, Hölzlwimmer, Gabriele, Javaheri, Anahita, Kalaydjiev, Svetoslav, Kallnik, Magdalena, Kling, Eva, Kunder, Sandra, Moßbrugger, Ilona, Naton, Beatrix, Racz, Ildikó, Rathkolb, Birgit, Rozman, Jan, Schrewe, Anja, Busch, Dirk H., Graw, Jochen, Ivandic, Boris, Klingenspor, Martin, Klopstock, Thomas, Ollert, Markus, Quintanilla-Martinez, Leticia, Schulz, Holger, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Fisher, Simon E., Morgenstern, Rudolf, Arendt, Thomas, Hrabé de Angelis, Martin, Fischer, Julia, Schwarz, Johannes, Pääbo, Svante

“…It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on…”
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