Search Results - "Sohn, Ock Soon"

Hypomethylation and hypermethylation of DNA in Wilms tumors by EHRLICH, Melanie, GUANCHAO JIANG, CHINTAGUMPALA, Murali, CHAMPAGNE, Martin, PARHAM, David, GANGNING LIANG, MALIK, Karim, LAIRD, Peter W, FIALA, Emerich, DOME, Jeffrey S, YU, Mimi C, LONG, Tiffany I, BYUNGWOO YOUN, SOHN, Ock-Soon, WIDSCHWENDTER, Martin, TOMLINSON, Gail E

“…We quantitatively analysed hypermethylation at CpG islands in the 5' ends of 12 genes and one non-CpG island 5' region (MTHFR) in 31 Wilms tumors. We also…”
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Chemoprevention of cancer by organoselenium compounds by el-Bayoumy, K, Upadhyaya, P, Chae, Y H, Sohn, O S, Rao, C V, Fiala, E, Reddy, B S

“…A major research goal of our laboratories is the development of new organoselenium cancer chemopreventive agents with less toxicity compared to some of the…”
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Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol by OCK SOON SOHN, FIALA, Emerich S, REQUEIJO, Silvia P, WEISBURGER, John H, GONZALEZ, Frank J

“…Methylazoxymethanol (MAM) and its chemical and metabolic precursor, azoxymethane (AOM), both strong colon carcinogens in rodents, can be metabolically…”
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Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E by Fiala, Emerich S., Sohn, Ock Soon, Wang, Chung-Xiou, Seibert, Eleanore, Tsurutani, Junji, Dennis, Phillip A., El-Bayoumy, Karam, Sodum, Rama S., Desai, Dhimant, Reinhardt, Joel, Aliaga, Cesar

“…The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by the availability of suitable…”
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Effect of dietary benzylselenocyanate on azoxymethane-induced colon carcinogenesis in male F344 rats by Nayini, J R, Sugie, S, el-Bayoumy, K, Rao, C V, Rigotty, J, Sohn, O S, Reddy, B S

“…The effect of dietary benzylselenocyanate (BSC) and its analogue, benzylthiocyanate (BTC), and sodium selenite during the initiation and postinitiation phases…”
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Comparative effects of phenylenebis(methylene)selenocyanate isomers on xenobiotic metabolizing enzymes in organs of female CD rats by Sohn, Ock Soon, Fiala, Emerich S., Upadhyaya, Pramod, Chae, Young-Heum, El-Bayoumy, Karam

“…The cancer chemopreventive agent 1,4-phenylenebis-(methylene)selenocyanate (p-XSC) inhibits various chemically induced tumors in laboratory animals. We…”
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Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1 by Sohn, O S, Ishizaki, H, Yang, C S, Fiala, E S

“…The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a…”
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Synthesis and excretion profile of 1,4-[14C]phenylenebis(methylene)selenocyanate in the rat by EL-BAYOUMY, K, UPADHYAYA, P, SOHN, O.-S, ROSA, J. G, FIALA, E. S

“…1,4-Phenylenebis(methylene)selenocyanate (p-XSC) inhibits chemically induced tumors in several laboratory animal models. To understand its mode of action, we…”
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Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate by FIALA, E. S, OCK SOON SOHN, LI, H, EL-BAYOUMY, K, SODUM, R. S

“…We observed that pretreatment of male F344 rats with benzyl selenocyanate, a versatile organoselenium chemopreventive agent in several animal model systems,…”
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Activation of the Liver Carcinogen 2-Nitropropane by Aryl Sulfotransferase by Sodum, Rama S, Sohn, Ock Soon, Nie, Guo, Fiala, Emerich S

“…8-Aminoguanine had previously been identified as one of the nucleic acid base modifications produced in livers of rats by treatment with the hepatocarcinogen…”
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Effects of chronic dietary ethanol on in vivo and in vitro metabolism of methylazoxymethanol and on methylazoxymethanol-induced DNA methylation in rat colon and liver by FIALA, E. S, OCK SOON SOHN, HAMILTON, S. R

“…We examined the metabolism of 14C-labeled methylazoxymethanol (MAM) in male F344 rats pair-fed for 21.0 days either a liquid control diet, an isocaloric liquid…”
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Effects of dietary restriction and fasting on selected rat liver enzymes of xenobiotic metabolism and on AOM-induced DNA guanine methylation in rat liver and colon by Sohn, O S, Fiala, E S

“…Using five- to eight-week-old male F344 rats and a high-fat (23.5% corn oil) modified AIN-76A diet, we examined the effects of dietary restriction (a 3-wk 30%…”
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2-Nitropropane-induced liver DNA and RNA base modifications: differences between Sprague-Dawley rats and New Zealand white rabbits by Fiala, E S, Nie, G, Sodum, R, Conaway, C C, Sohn, O S

“…2-Nitropropane (2-NP), a hepatocarcinogen in male Sprague-Dawley rats but not, under the same conditions, in male New Zealand White rabbits, induces…”
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Metabolism of [14C]benzyl selenocyanate in the F344 rat by El-Bayoumy, Karam, Upadhyaya, Pramod, Date, Vandana, Sohn, Ock Soon, Fiala, Emerich S, Reddy, Bandaru

“…Benzyl selenocyanate (BSC), a synthetic organoselenium compound, has been shown to inhibit chemically induced tumors in several animal model systems. However,…”
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Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate by PROKOPCZYK, Bogdan, ROSA, José G, DESAI, Dhimant, AMIN, Shantu, SOHN, Ock Soon, FIALA, Emerich S, EL-BAYOUMY, Karam

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Inhibition by dietary ethanol of experimental colonic carcinogenesis induced by high-dose azoxymethane in F344 rats by HAMILTON, S. R, OCK SOON SOHN, FIALA, E. S

“…Epidemiological studies have shown an association between consumption of alcoholic beverages and increased occurrence of large bowel carcinoma, but studies in…”
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Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate by Prokopczyk, B, Rosa, J G, Desai, D, Amin, S, Sohn, O S, Fiala, E S, El-Bayoumy, K

“…We evaluated the chemopreventive efficacy of the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate (p-XSC) against the development of tumors of…”
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Separation of morpholine and some of its metabolites by high-performance liquid chromatography by Sohn, O S, Fiala, E S, Conaway, C C, Weisburger, J H

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Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate by Sohn, Ock Soon, Desai, Dhimant H., Das, Arunangshu, Rodriguez, Jose G., Amin, Shantu G., El-Bayoumy, Karam

“…In a previous preliminary investigation, we reported on the excretion, tissue disposition and metabolism of the chemopreventive agent…”
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Mechanisms of organoselenium compounds in chemoprevention: Effects on transcription factor-DNA binding: Selenium and cancer: Larry C. Clark memorial issue by YOUN, B. Woo, FIALA, Emerich S, OCK SOON SOHN

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