Search Results - "Sohn, Mi Jin"
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Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action
Published in PloS one (28-11-2013)“…Bacterial enoyl-acyl carrier protein reductase (FabI) is a promising novel antibacterial target. We isolated a new class of FabI inhibitor from Penicillium…”
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Chalcomoracin and Moracin C, New Inhibitors of Staphylococcus aureus Enoyl-Acyl Carrier Protein Reductase from Morus alba
Published in Biological & pharmaceutical bulletin (01-05-2012)“…Bacterial enoyl-acyl carrier protein (ACP) reductase has been confirmed as a novel target for antibacterial drug development. In the screening of inhibitors of…”
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Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson’s Disease
Published in Journal of natural products (Washington, D.C.) (24-06-2016)“…Nurr1 is an orphan nuclear receptor that is essential for the differentiation and maintenance of dopaminergic neurons in the brain, and it is a therapeutic…”
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The Lactone Form of Stachybotrydial: A New Inhibitor of Dihydrofolate Reductase from Stachybotrys sp. FN298
Published in Biological & pharmaceutical bulletin (01-08-2014)“…Dihydrofolate reductase (DHFR) has been confirmed to be a novel target for antibacterial drug development. In this study, we determined that a fungal…”
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AN483, a new anti-MRSA compound from Streptomyces sp
Published in Journal of antibiotics (01-10-2016)Get full text
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One-chip electronic detection of DNA hybridization using precision impedance-based CMOS array sensor
Published in Biosensors & bioelectronics (15-12-2010)“…This paper describes a label-free and fully electronic detection method of DNA hybridization, which is achieved through the use of a 16 × 8 microarray sensor…”
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Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus
Published in Bioorganic & medicinal chemistry letters (15-03-2011)“…A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was…”
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Vinaxanthone, a new FabI inhibitor from Penicillium sp
Published in Journal of antimicrobial chemotherapy (01-05-2009)“…Objectives Bacterial enoyl-ACP reductase (FabI) has been validated as a novel antibacterial target for tackling infections caused by multidrug-resistant…”
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Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae
Published in Journal of antibiotics (01-12-2006)“…Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of…”
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Cephalochromin, a FabI-directed antibacterial of microbial origin
Published in Biochemical and biophysical research communications (03-11-2007)“…Microorganisms produce many kinds of antibiotics which function in an antagonistic capacity in nature where they have much competition. Bacterial enoyl-acyl…”
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Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28
Published in Journal of antibiotics (01-11-2008)“…In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound…”
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Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611
Published in Journal of antibiotics (01-02-2011)Get full text
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Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the dimerization of inducible nitric oxide synthase
Published in Biochemical pharmacology (15-02-2008)“…Dimerization of inducible NOS has been known to be a potential therapeutic target for iNOS-mediated pathologies. Cyclic dipeptides are among the simplest…”
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Isolation and identification of pentagalloylglucose with broad-spectrum antibacterial activity from Rhus trichocarpa Miquel
Published in Food chemistry (15-11-2010)“…Rhus trichocarpa Miquel has been utilised both as a food and for medicinal purposes. In this study, we determined that the methanol extracts of the stem and…”
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Verrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375
Published in Bioorganic & medicinal chemistry letters (01-01-2014)“…An highly quaternary and unprecedented dispiro compound, verrulactone C, with the known compound, altenuisol, were isolated from a culture broth of the fungal…”
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Flavimycins A and B, Dimeric 1,3-Dihydroisobenzofurans with Peptide Deformylase Inhibitory Activity from Aspergillus flavipes
Published in Journal of natural products (Washington, D.C.) (24-02-2012)“…Flavimycins A (1) and B (2), novel dimeric 1,3-dihydroisobenzofurans, were isolated as inhibitors of peptide deformylase from cultures of Aspergillus flavipes…”
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Fumimycin: A Peptide Deformylase Inhibitor with an Unusual Skeleton Produced by Aspergillus fumisynnematus
Published in Organic letters (21-06-2007)“…Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was…”
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Novel optical absorbance-based multi-analytes detection module using a tri-chromatic LED, PDs and plastic optical fibers and its application to a palm-sized urine test strip reader
Published in 2010 IEEE Sensors (01-11-2010)“…We have designed, fabricated and characterized a new palm-sized urine test strip reader (9.5 × 6.5 × 1.8 cm 3 ) using a novel optical absorbance-based…”
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Conference Proceeding -
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Panosialins, Inhibitors of Enoyl-ACP Reductase from Streptomyces sp. AN1761
Published in Journal of microbiology and biotechnology (28-02-2013)“…In the continued search for inhibitors of enoyl-acyl carrier protein (ACP) reductase, we found that four acylbenzenediol sulfate metabolites from Streptomyces…”
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