Search Results - "Sohn, D‐R"

Pharmacokinetic and Pharmacodynamic Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 Genetic Polymorphism in Healthy Subjects by Chung, J‐Y, Cho, J‐Y, Yu, K‐S, Kim, J‐R, Lim, KS, Sohn, D‐R, Shin, S‐G, Jang, I‐J

“…Pharmacokinetic and pharmacodynamic profiles of lorazepam and valproate were analyzed according to uridine 5′‐diphosphate‐glucuronosyltransferase (UGT)2B7…”
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Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population by Kim, H-K, Joo, J-S, Lee, H-Y, Kwon, J-T, Sohn, D-R, Hong, S-J, Kim, H-J

“…Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures…”
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Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone by Yoo, H. H., Kim, N. S., Lee, J., Sohn, D. R., Jin, C., Kim, D. H.

“…Eperisone is a centrally acting muscle relaxant widely used for the therapeutic treatment of spastic patients to relieve muscle stiffness and back pain. The…”
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Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population by Sohn, D R, Kobayashi, K, Chiba, K, Lee, K H, Shin, S G, Ishizaki, T

“…To explore the relationship between omeprazole disposition and genetically determined S-mephenytoin 4'-hydroxylation phenotype status, we examined the kinetic…”
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Metabolic disposition of lansoprazole in relation to the S‐mephenytoin 4′‐hydroxylation phenotype status by Sohn, Dong‐Ryul, Kwon, Jun‐Tack, Kim, Hyung‐Kee, Ishizaki, Takashi

“…Objective To assess the possible involvement of CYP2C19 in the metabolism of lansoprazole in vivo. Methods Sixteen male Korean subjects, who had been…”
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Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals by Ishizaki, T, Sohn, D R, Kobayashi, K, Chiba, K, Lee, K H, Shin, S G, Andersson, T, Regårdh, C G, Lou, Y C, Zhang, Y

“…Two independent studies showed that the 5-hydroxylation, but not the sulfoxidation, of omeprazole is more rapid in extensive metabolizers (EMs) than in poor…”
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Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes by Koyama, E, Sohn, D R, Shin, S G, Chiba, K, Shin, J G, Kim, Y H, Echizen, H, Ishizaki, T

“…We studied the metabolic disposition of imipramine by measuring imipramine and its metabolites in plasma and urine simultaneously after a single oral dose of…”
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Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics by Sohn, D R, Kusaka, M, Ishizaki, T, Shin, S G, Jang, I J, Shin, J G, Chiba, K

“…We studied the genetically determined hydroxylation polymorphism of S-mephenytoin in a Korean population (N = 206) and the pharmacokinetics of diazepam and…”
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Erythrocyte thiopurine methyltransferase activity in a Korean population by JANG, I. J, SHIN, S. G, LEE, K. H, YIM, D. S, LEE, M. S, KOO, H. H, KIM, H. K, SOHN, D. R

“…Thiopurine methyltransferase (TPMT) is the enzyme responsible for the S-methylation of thiopurine drugs. The enzyme, present in human red blood cells (RBC), is…”
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Dihydropyrimidine dehydrogenase activity in a Korean population by SOHN, D.-R, MOO SIK CHO, CHUNG, P.-J

“…Dihydropyrimidine dehydrogenase (DPD) is the major metabolic enzyme in the catabolism of 5-fluorouracil, and the activity in normal tissues shows a wide…”
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Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations by Sohn, D R, Kusaka, M, Shin, S G, Jang, I J, Chiba, K, Ishizaki, T

“…We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type…”
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Nicotine metabolism and CYP2A6 allele frequencies in Koreans by KWON, Jun-Tack, NAKAJIMA, Miki, SEOK CHAI, YOM, Yoon-Ki, KIM, Hyung-Kee, YAMAZAKI, Hiroshi, SOHN, Dong-Ryul, YAMAMOTO, Toshinori, KUROIWA, Yukio, YOKOI, Tsuyoshi

“…CYP2A6 is a major catalyst of nicotine metabolism to cotinine. Previously, we demonstrated that the interindividual difference in nicotine metabolism is…”
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The pharmacokinetics of omeprazole in relation to the genotypes of the S‐mephenytoin hydroxylase by Chai, S., Kwon, J.‐T., Yang, D.‐G., Kim, H.‐K., Sohn, D.‐R.

“…Clinical Pharmacology & Therapeutics (1999) 65, 127–127; doi:…”
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Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations by Sohn, DR, Shin, SG, Park, CW, Kusaka, M, Chiba, K, Ishizaki, T

“…We examined metoprolol oxidation capacity in 218 unrelated, healthy Korean subjects using the 8 h urinary metabolic ratio (MR) of metoprolol to…”
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Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed-phase high-performance liquid chromatography with an alkaline-resistant polymer-coated C18 column by Kobayashi, K, Chiba, K, Sohn, D R, Kato, Y, Ishizaki, T

“…Omeprazole (OPZ) is a proton pump inhibitor in gastric parietal cells. A reversed-phase high-performance liquid chromatographic method was developed that…”
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The genetic polymorphism of angiotensin-converting enzyme in a Korean population by Sohn, D R, Kwon, J T, Kim, H K

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Pharmacokinetic and Pharmacodynamic Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 Genetic Polymorphism in Healthy Subjects: Addictions by CHUNG, J.-Y, CHO, J.-Y, YU, K.-S, KIM, J.-R, LIM, K. S, SOHN, D.-R, SHIN, S.-G, JANG, I.-J

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Endothelial potentiation of relaxation response to ascorbic acid in rat and guinea pig thoracic aorta by Chang, K C, Chong, W S, Sohn, D R, Kwon, B H, Lee, I J, Kim, C Y, Yang, J S, Joo, J I

“…The role of the endothelium was evaluated in the relaxation of rat and guinea pig aortic rings induced by ascorbic acid. Ascorbic acid relaxed rat and guinea…”
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The Gene Polymorphism of Angiotensinconverting Enzyme in Patients With Ischemic Stroke by Kwon, J.‐T, Kim, H.‐K, Chai, S., Yang, D.‐G., Bang, C.‐O., Park, H.‐K., Shin, H.‐K., Seong, K.‐B, Sohn, D.‐R.

“…Clinical Pharmacology & Therapeutics (1999) 65, 166–166; doi:…”
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Erythrocyte thiopurine methyltransferase activity in a Korean population by JANG, I. J., SHIN, S. G., LEE, K. H., YIM, D. S., LEE, M. S., KOO, H. H., KIM, H. K., SOHN, D. R.

“…Thiopurine methyltransferase (TPMT) is the enzyme responsible for the S‐methylation of thiopurine drugs. The enzyme, present in human red blood cells (RBC), is…”
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