Search Results - "Sohal, Rajindar S."

Caloric restriction and the aging process: a critique by Sohal, Rajindar S., Forster, Michael J.

“…The main objective of this review is to provide an appraisal of the current status of the relationship between energy intake and the life span of animals. The…”
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Pro-oxidant shift in glutathione redox state during aging by Rebrin, Igor, Sohal, Rajindar S.

“…The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an…”
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Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila by Radyuk, Svetlana N, Michalak, Katarzyna, Klichko, Vladimir I, Benes, Judith, Rebrin, Igor, Sohal, Rajindar S, Orr, William C

“…Peroxiredoxin 5 is a distinct isoform of the peroxiredoxin gene family. The antioxidative and anti-apoptotic functions of peroxiredoxin 5 have been extensively…”
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Age-associated perturbations in glutathione synthesis in mouse liver by Toroser, Dikran, Sohal, Rajindar S

“…The nature of the mechanisms underlying the age-related decline in glutathione (GSH) synthetic capacity is at present unclear. Steady-state kinetic parameters…”
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Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster by Ferguson, Melissa, Mockett, Robin J, Shen, Yi, Orr, William C, Sohal, Rajindar S

“…The principal objective of the present study was to identify specific alterations in mitochondrial respiratory functions during the aging process. Respiration…”
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Effects of age and caloric restriction on glutathione redox state in mice by Rebrin, Igor, Kamzalov, Sergey, Sohal, Rajindar S

“…The main purpose of this study was to determine whether the aging process in the mouse is associated with a pro-oxidizing shift in the redox state of…”
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Oxidative Stress, Caloric Restriction, and Aging by Sohal, Rajindar S., Weindruch, Richard

“…Under normal physiological conditions, the use of oxygen by cells of aerobic organisms generates potentially deleterious reactive oxygen metabolites. A chronic…”
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Overexpression of Glucose-6-phosphate Dehydrogenase Extends the Life Span of Drosophila melanogaster by Legan, Susan K., Rebrin, Igor, Mockett, Robin J., Radyuk, Svetlana N., Klichko, Vladimir I., Sohal, Rajindar S., Orr, William C.

“…The redox state of tissues tends to become progressively more prooxidizing during the aging process. The hypothesis tested in this study was that enhancement…”
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Association between life-span extension by caloric restriction and thiol redox state in two different strains of mice by Rebrin, Igor, Forster, Michael J., Sohal, Rajindar S.

“…The hypothesis that the life-extending effect of caloric restriction (CR) is associated with an attenuation of the age-related pro-oxidant shift in the thiol…”
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Genotype and age influence the effect of caloric intake on mortality in mice by Forster, Michael J., Morris, Paul, Sohal, Rajindar S.

“…ABSTRACT Long‐term caloric restriction (CR) has been repeatedly shown to increase life span and delay the onset of age‐associated pathologies in laboratory…”
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Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan by Klichko, Vladimir, Sohal, Barbara H, Radyuk, Svetlana N, Orr, William C, Sohal, Rajindar S

“…The phenotypic effects of under- and over-expression of CcO (cytochrome c oxidase) regulatory subunits IV and Vb were examined in Drosophila melanogaster in…”
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redox stress hypothesis of aging by Sohal, Rajindar S, Orr, William C

“…The main objective of this review is to examine the role of endogenous reactive oxygen/nitrogen species (ROS) in the aging process. Until relatively recently,…”
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Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 mice by Rebrin, Igor, Forster, Michael J, Sohal, Rajindar S

“…Abstract The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative…”
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Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster by Orr, William C., Mockett, Robin J., Benes, Judith J., Sohal, Rajindar S.

“…The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD), Mn-SOD, and catalase has previously been reported to extend life span in…”
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Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster by Ren, Jian-Ching, Rebrin, Igor, Klichko, Vladimir, Orr, William C., Sohal, Rajindar S.

“…► Cytochrome c oxidase loses catalytic activity during the aging process. ► Abundance of seven nuclear-encoded subunits of cytochrome c oxidase decreased with…”
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Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila by Bayne, Anne-Cécile V, Mockett, Robin J, Orr, William C, Sohal, Rajindar S

“…The generation of superoxide anion radicals (O2*-) and hydrogen peroxide (H2O2) during mitochondrial respiration has been widely postulated to be causally…”
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Mitochondrial Adenine Nucleotide Translocase is Modified Oxidatively during Aging by Yan, Liang-Jun, Sohal, Rajindar S.

“…The purpose of this study was to test the hypothesis that elevation in protein oxidative damage during the aging process is a targeted rather than a stochastic…”
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Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice by McDonald, Shelley R, Sohal, Rajindar S, Forster, Michael J

“…The main purpose of this study was to determine whether supplemental intake of coenzyme Q10 (CoQ) (ubiquinone-10) or alpha-tocopherol, either alone or…”
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Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat by Kwong, Linda K, Kamzalov, Sergey, Rebrin, Igor, Bayne, Anne-Cécile V, Jana, Chandan K, Morris, Paul, Forster, Michael J, Sohal, Rajindar S

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Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage by Yan, Liang-Jun, Christians, Elisabeth S., Liu, Li, Xiao, XianZhong, Sohal, Rajindar S., Benjamin, Ivor J.

“…In this study, using heat shock factor 1 (Hsf1) knockout mice as a model, we tested the hypothesis that HSF1‐dependent regulation of heat shock proteins (Hsps)…”
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