Search Results - "Soh, Thomas I P"
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Correlation of aldo‐ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients
Published in British journal of clinical pharmacology (01-06-2013)“…Aims Aldo‐ketoreductases have been implicated in the metabolism of doxorubicin. We sought to assess the influence of AKR1C3 genetic variants on doxorubicin…”
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Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer
Published in Oncotarget (27-09-2016)“…Prolonged anti-angiogenic therapy destroys tumor vasculature, whereas vascular-normalizing doses may enhance intra-tumoral drug delivery. We hypothesize that…”
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Germline genetic testing to predict drug response and toxicity in oncology--reality or fiction?
Published in Annals of the Academy of Medicine, Singapore (01-08-2011)“…In addition to 6-mercaptopurine, 5-fluorouracil and irinotecan, the United States Food and Drug Administration (US FDA) has recently recommended label change…”
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