Search Results - "Sodora, Donald L."

Oral Immunization with HIV-1 Envelope SOSIP trimers elicits systemic immune responses and cross-reactive anti-V1V2 antibodies in non-human primates by Fisher, Bridget S, Dambrauskas, Nicholas, Trakhimets, Olesya, Andrade, Daniela V, Smedley, Jeremy, Sodora, Donald L, Sather, D Noah

“…Development of a successful HIV vaccine is dependent upon a determination of the optimum antigen and adjuvant as well as choosing an optimal site for vaccine…”
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Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts by Silvestri, Guido, Sodora, Donald L, Allan, Jonathan S, Apetrei, Cristian, Brenchley, Jason M, Douek, Daniel C, Else, James G, Estes, Jacob D, Hahn, Beatrice H, Hirsch, Vanessa M, Kaur, Amitinder, Kirchhoff, Frank, Muller-Trutwin, Michaela, Pandrea, Ivona, Schmitz, Jörn E

“…The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine…”
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Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques by Harris, Levelle D, Tabb, Brian, Sodora, Donald L, Paiardini, Mirko, Klatt, Nichole R, Douek, Daniel C, Silvestri, Guido, Müller-Trutwin, Michaela, Vasile-Pandrea, Ivona, Apetrei, Cristian, Hirsch, Vanessa, Lifson, Jeffrey, Brenchley, Jason M, Estes, Jacob D

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Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques by Steele, Amanda K, Carrasco-Medina, Lorna, Sodora, Donald L, Crawley, Angela M

“…The use of interleukin-7 (IL-7) as an immunorestorative therapeutic has proven effective in HIV infection, cancer and bone marrow transplantation. Mediating…”
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Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta) by Smedley, Jeremy V., Bochart, Rachele M., Fischer, Miranda, Funderburgh, Heidi, Kelly, Vanessa, Crank, Hugh, Armantrout, Kim, Shiel, Oriene, Robertson‐LeVay, Mitchell, Sternberger, Nikki, Schmaling, Brian, Roberts, Sheila, Sekiguchi, Vicki, Reusz, Michael, Schwartz, Tiah, Meyer, Kimberly A., Webb, Gabriela, Gilbride, Roxanne M., Dambrauskas, Nicholas, Andrade, Daniela, Wood, Matthew, Labriola, Caralyn, Axthelm, Michael, Derby, Nina, Varco‐Merth, Ben, Fukazawa, Yoshinori, Hansen, Scott, Sacha, Jonah B., Sodora, Donald L., Sather, D. Noah

“…Background Identification of lymph nodes (LNs) draining a specific site or in obese macaques can be challenging. Methods Indocyanine Green (ICG) was…”
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Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques by Wood, Matthew P, Jones, Chloe I, Lippy, Adriana, Oliver, Brian G, Walund, Brynn, Fancher, Katherine A, Fisher, Bridget S, Wright, Piper J, Fuller, James T, Murapa, Patience, Habib, Jakob, Mavigner, Maud, Chahroudi, Ann, Sather, D Noah, Fuller, Deborah H, Sodora, Donald L

“…HIV-infected infants are at an increased risk of progressing rapidly to AIDS in the first weeks of life. Here, we evaluated immunological and virological…”
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SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo by Derby, Nina, Biswas, Sreya, Yusova, Sofiya, Luevano-Santos, Cristina, Pacheco, Maria Cristina, Meyer, Kimberly A, Johnson, Brooke I, Fischer, Miranda, Fancher, Katherine A, Fisher, Cole, Abraham, Yohannes M, McMahon, Conor J, Lutz, Savannah S, Smedley, Jeremy V, Burwitz, Benjamin J, Sodora, Donald L

“…Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a major cause of morbidity and mortality in HIV-infected individuals, even those receiving…”
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Simian Immunodeficiency virus-Induced Lymphatic Tissue Fibrosis Is Mediated by Transforming Growth Factor β1-positive Regulatory T Cells and Begins in Early Infection by Estes, Jacob D., Wietgrefe, Stephen, Schacker, Timothy, Southern, Peter, Beilman, Greg, Reilly, Cavan, Milush, Jeffrey M., Lifson, Jeffrey D., Sodora, Donald L., Carlis, John V., Haase, Ashley T.

“…In human immunodeficiency virus (HIV) infection, collagen deposition and fibrosis within the T cell zone disrupt the lymphatic tissue architecture,…”
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Liver Bacterial Dysbiosis With Non-Tuberculosis Mycobacteria Occurs in SIV-Infected Macaques and Persists During Antiretroviral Therapy by Fisher, Bridget S, Fancher, Katherine A, Gustin, Andrew T, Fisher, Cole, Wood, Matthew P, Gale, Jr, Michael, Burwitz, Benjamin J, Smedley, Jeremy, Klatt, Nichole R, Derby, Nina, Sodora, Donald L

“…Liver disease is a significant contributor to morbidity and mortality in HIV-infected individuals, even during successful viral suppression with combination…”
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Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART by Fisher, Bridget S, Green, Richard R, Brown, Rachel R, Wood, Matthew P, Hensley-McBain, Tiffany, Fisher, Cole, Chang, Jean, Miller, Andrew D, Bosche, William J, Lifson, Jeffrey D, Mavigner, Maud, Miller, Charlene J, Gale, Jr, Michael, Silvestri, Guido, Chahroudi, Ann, Klatt, Nichole R, Sodora, Donald L

“…Liver disease is a leading contributor to morbidity and mortality during HIV infection, despite the use of combination antiretroviral therapy (cART). The…”
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Nonpathogenic SIV Infection of Sooty Mangabeys Is Characterized by Limited Bystander Immunopathology Despite Chronic High-Level Viremia by Silvestri, Guido, Sodora, Donald L., Koup, Richard A., Paiardini, Mirko, O'Neil, Shawn P., McClure, Harold M., Staprans, Silvija I., Feinberg, Mark B.

“…HIV-infected humans and SIV-infected rhesus macaques who remain healthy despite long-term infection exhibit exceptionally low levels of virus replication and…”
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A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo by Riddick, Nadeene E, Hermann, Emilia A, Loftin, Lamorris M, Elliott, Sarah T, Wey, Winston C, Cervasi, Barbara, Taaffe, Jessica, Engram, Jessica C, Li, Bing, Else, James G, Li, Yingying, Hahn, Beatrice H, Derdeyn, Cynthia A, Sodora, Donald L, Apetrei, Cristian, Paiardini, Mirko, Silvestri, Guido, Collman, Ronald G

“…In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust…”
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Nonpathogenic SIV and Pathogenic HIV Infections Associate with Disparate Innate Cytokine Signatures in Response to Mycobacterium bovis BCG by Gasper, Melanie A, Biswas, Shameek P, Fisher, Bridget S, Ehnert, Stephanie C, Sherman, David R, Sodora, Donald L

“…Infections with mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis (M. bovis) BCG, are a leading cause of morbidity and mortality…”
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Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection by Sundaravaradan, Vasudha, Saleem, Ramsey, Micci, Luca, Gasper, Melanie A, Ortiz, Alexandra M, Else, James, Silvestri, Guido, Paiardini, Mirko, Aitchison, John D, Sodora, Donald L

“…Studying SIV infection of natural host monkey species, such as sooty mangabeys, has provided insights into the immune changes associated with these…”
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T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure by Wood, Lianna Frances, Wood, Matthew P, Fisher, Bridget S, Jaspan, Heather B, Sodora, Donald L

“…The introduction of non-breastmilk foods to HIV-infected infants is associated with increased levels of immune activation, which can impact the rate of HIV…”
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Evidence of Early B-Cell Dysregulation in Simian Immunodeficiency Virus Infection: Rapid Depletion of Naïve and Memory B-Cell Subsets with Delayed Reconstitution of the Naïve B-Cell Population by KUHRT, David, FAITH, Seth A, LEONE, Amanda, ROHANKEDKAR, Mukta, SODORA, Donald L, PIEKER, Louis J, STEFANO COLE, Kelly

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Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys by DURUDAS, Andre, MILUSH, Jeffrey M, CHEN, Hui-Ling, ENGRAM, Jessica C, SILVESTRI, Guido, SODORA, Donald L

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Alpha Interferon Induces Distinct Translational Control Programs To Suppress Hepatitis C Virus RNA Replication by Wang, Chunfu, Pflugheber, Jill, Sumpter, Jr, Rhea, Sodora, Donald L, Hui, Daniel, Sen, Ganes C, Gale, Jr, Michael

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Link between Primate Lentiviral Coreceptor Usage and Nef Function by Schmökel, Jan, Li, Hui, Shabir, Asma, Yu, Hangxing, Geyer, Matthias, Silvestri, Guido, Sodora, Donald L., Hahn, Beatrice H., Kirchhoff, Frank

“…Simian immunodeficiency virus (SIVsmm) infection of sooty mangabeys (Cercocebus atys) is characterized by stable CD4+ T cell counts despite high plasma levels…”
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Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys Is Not Associated with High Levels of Autologous Neutralizing Antibodies by Li, Bing, Stefano-Cole, Kelly, Kuhrt, David M, Gordon, Shari N, Else, James G, Mulenga, Joseph, Allen, Susan, Sodora, Donald L, Silvestri, Guido, Derdeyn, Cynthia A

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