Search Results - "Soddu, S"

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist by Ubertini, V, Norelli, G, D'Arcangelo, D, Gurtner, A, Cesareo, E, Baldari, S, Gentileschi, M P, Piaggio, G, Nisticò, P, Soddu, S, Facchiano, A, Bossi, G

“…The TP53 tumor-suppressor gene is frequently mutated in human cancer. Missense mutations can add novel functions (gain-of-function, GOF) that promote tumor…”
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Covid-19 in Philadelphia-negative myeloproliferative neoplasms: a GIMEMA survey on incidence, clinical management and vaccine by Breccia, M., Piciocchi, A., Messina, M., Soddu, S., De Stefano, V., Bellini, M., Iurlo, A., Martino, B., Siragusa, S., Albano, F., Mora, B., Fazi, P., Vignetti, M., Guglielmelli, P., Palandri, F.

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MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response by Mancini, F, Pieroni, L, Monteleone, V, Lucà, R, Fici, L, Luca, E, Urbani, A, Xiong, S, Soddu, S, Masetti, R, Lozano, G, Pontecorvi, A, Moretti, F

“…The p53 inhibitor, MDM4 (MDMX) is a cytoplasmic protein with p53-activating function under DNA damage conditions. Particularly, MDM4 promotes phosphorylation…”
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Pax8 has a critical role in epithelial cell survival and proliferation by Di Palma, T, Filippone, M G, Pierantoni, G M, Fusco, A, Soddu, S, Zannini, M

“…The transcription factor Pax8, a member of the Paired-box gene family, is a critical regulator required for proper development and differentiation of thyroid…”
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hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells by Trono, P, Di Modugno, F, Circo, R, Spada, S, Di Benedetto, A, Melchionna, R, Palermo, B, Matteoni, S, Soddu, S, Mottolese, M, De Maria, R, Nisticò, P

“…Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in…”
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HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage by Lazzari, C, Prodosmo, A, Siepi, F, Rinaldo, C, Galli, F, Gentileschi, M, Bartolazzi, A, Costanzo, A, Sacchi, A, Guerrini, L, Soddu, S

“…Homeodomain-interacting protein kinase 2 (HIPK2) is an emerging player in cell response to genotoxic agents that senses damage intensity and contributes to the…”
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HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation by De Nicola, F, Catena, V, Rinaldo, C, Bruno, T, Iezzi, S, Sorino, C, Desantis, A, Camerini, S, Crescenzi, M, Floridi, A, Passananti, C, Soddu, S, Fanciulli, M

“…Che-1/AATF is an RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in…”
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High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity by Pierantoni, G M, Rinaldo, C, Esposito, F, Mottolese, M, Soddu, S, Fusco, A

“…HMGA gene overexpression and rearrangements are frequent in several tumours, but their oncogenic function is still unclear. Here we report of a physical and…”
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p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation by Tritarelli, A, Oricchio, E, Ciciarello, M, Mangiacasale, R, Palena, A, Lavia, P, Soddu, S, Cundari, E

“…We recently demonstrated that the p53 oncosuppressor associates to centrosomes in mitosis and this association is disrupted by treatments with…”
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IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study by Soddu, S, Di Felice, E, Cabras, S, Castellanos, M E, Atzori, L, Faa, G, Pilloni, L

“…The protein insulin-like growth factor II mRNA binding protein 3 (IMP3) is an important factor for cell migration and adhesion in malignancies. Recent studies…”
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HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage by Iacovelli, S., Ciuffini, L., Lazzari, C., Bracaglia, G., Rinaldo, C., Prodosmo, A., Bartolazzi, A., Sacchi, A., Soddu, S.

“…Introduction/objectives:  The serine/threonine kinase homeodomain‐interacting protein kinase 2 (HIPK2) is a co‐regulator of an increasing number of…”
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467 HIPK2 in the Control of Chromosomal Instability – a New Mechanism in Tumorigenesis by Valente, D, Moncada, A, Bossi, G, Magi, F, Conte, A, Gerlini, R, Pierantoni, G.M, Soddu, S, Rinaldo, C

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p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2 MAPK by Marchetti, A, Cecchinelli, B, D'Angelo, M, D'Orazi, G, Crescenzi, M, Sacchi, A, Soddu, S

“…Stimulation of the Ras/MAPK cascade can either activate p53 and promote replicative senescence and apoptosis, or degrade p53 and promote cell survival. Here we…”
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W239 PLACENTAL GROWTH FACTOR (PLGF): CORRELATIONS WITH PLACENTAL FUNCTION by Atzeni, I., Paoletti, A.M., Deiana, S.F., Meloni, A., Guerriero, S., Parodo, G., Faa, G., Soddu, S., Cabiddu, E., Tocco, S.

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Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis by Cecchinelli, B, Porrello, A, Lazzari, C, Gradi, A, Bossi, G, D'Angelo, M, Sacchi, A, Soddu, S

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Serum anti-p53 antibodies as a useful marker for prognosis of gastric carcinoma by MATTIONI, M, SODDU, S, PORRELLO, A, D'ALESSANDRO, R, SPILA, A, GUADAGNI, F

“…Mutations in the TP53 gene are the most common genetic alterations in cancer. Accumulation of mutated protein may induce circulating anti-p53 antibodies…”
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p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts by Cerone, M A, Marchetti, A, Bossi, G, Blandino, G, Sacchi, A, Soddu, S

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Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation by RIZZO, M. G, ZEPPARONI, A, CRISTOFANELLI, B, SCARDIGLI, R, CRESCENZI, M, BLANDINO, G, GIULIACCI, S, FERRARI, S, SODDU, S, SACCHI, A

“…Recent studies support the potential application of the wt-p53 gene in cancer therapy. Expression of exogenous wt-p53 suppresses a variety of leukaemia…”
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Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule by BIROCCIO, A, DEL BUFALO, D, RICCA, A, D'ANGELO, C, D'ORAZI, G, SACCHI, A, SODDU, S, ZUPI, G

“…In this article, we investigated the effect induced by the reintroduction of wild-type p53 (wt-p53) protein on BCNU sensitivity in the ADF glioblastoma line…”
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Expression of exogenous wt-p53 does not affect normal hematopoiesis : implications for bone marrow purging by SCARDIGLI, R, BOSSI, G, BLANDINO, C, CRESCENZI, M, SODDU, S, SACCHI, A

“…Some gene therapy approaches for cancer treatment attempt to transduce onco-suppressor genes into tumor cells. A central problem of this strategy is the…”
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