Search Results - "Sodani, Kamlesh"

Revisiting the ABCs of multidrug resistance in cancer chemotherapy by Tiwari, Amit K, Sodani, Kamlesh, Dai, Chun-Ling, Ashby, Jr, Charles R, Chen, Zhe-Sheng

“…The adenosine tri-phosphate binding cassette (ABC) transporters are one of the largest transmembrane gene families in humans. The ABC transporters are present…”
Get more information

Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models by Tiwari, Amit K, Sodani, Kamlesh, Dai, Chun-ling, Abuznait, Alaa H, Singh, Satyakam, Xiao, Zhi-Jie, Patel, Atish, Talele, Tanaji T, Fu, Liwu, Kaddoumi, Amal, Gallo, James M, Chen, Zhe-Sheng

“…Highlights ► Nilotinib compared to panel of tyrosine kinase inhibitors most potently reverse ABCB1, ABCG2 and ABCC10 transporters mediated drug resistance. ►…”
Get full text

GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance by Sodani, Kamlesh, Tiwari, Amit K., Singh, Satyakam, Patel, Atish, Xiao, Zhi-Jie, Chen, Jun-Jiang, Sun, Yue-Li, Talele, Tanaji T., Chen, Zhe-Sheng

“…The overexpression of ATP binding cassette (ABC) transporters often leads to the development of multidrug resistance (MDR) and results in a suboptimal response…”
Get full text

Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar by Sun, Yue-Li, Chen, Jun-Jiang, Kumar, Priyank, Chen, Kang, Sodani, Kamlesh, Patel, Atish, Chen, Yang-Lu, Chen, Si-Dong, Jiang, Wen-Qi, Chen, Zhe-Sheng

“…Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable of conferring…”
Get full text

PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP‐binding Cassette C10) transporter by Chen, Jun‐Jiang, Sun, Yue‐Li, Tiwari, Amit K., Xiao, Zhi‐Jie, Sodani, Kamlesh, Yang, Dong‐Hua, Vispute, Saraubh G., Jiang, Wen‐Qi, Chen, Si‐Dong, Chen, Zhe‐Sheng

“…Phosphodiesterase type 5 (PDE5) inhibitors are widely used in the treatment of male erectile dysfunction and pulmonary hypertension. Recently, several groups…”
Get full text

WHI‐P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2‐overexpressing cells by Zhang, Hui, Zhang, Yun‐Kai, Wang, Yi‐Jun, Kathawala, Rishil J., Patel, Atish, Zhu, Hua, Sodani, Kamlesh, Talele, Tanaji T., Ambudkar, Suresh V., Chen, Zhe‐Sheng, Fu, Li‐Wu

“…ATP‐binding cassette (ABC) transmembrane proteins evidently decrease the intracellular accumulation of substrate chemotherapeutic drugs by extruding them…”
Get full text

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion by Whitt, Jason D, Keeton, Adam B, Gary, Bernard D, Sklar, Larry A, Sodani, Kamlesh, Chen, Zhe-Sheng, Piazza, Gary A

“…ATP-binding cassette（ABC） transporters ABCC1（MRP1）,ABCB1（P-gp）,and ABCG2（BCRP） contribute to chemotherapy failure.The primary goals of this study were to…”
Get full text

bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10) by Chen, Jun-Jiang, Patel, Atish, Sodani, Kamlesh, Xiao, Zhi-Jie, Tiwari, Amit K, Zhang, Dong-Mei, Li, Ying-Jie, Yang, Dong-Hua, Ye, Wen-Cai, Chen, Si-Dong, Chen, Zhe-Sheng

“…Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic…”
Get full text

Multidrug resistance associated proteins in multidrug resistance by Sodani, Kamlesh, Patel, Atish, Kathawala, Rishil J, Chen, Zhe-Sheng

“…Multidrug resistance proteins （MRPs） are members of the C family of a group of proteins named ATP- binding cassette （ABC） transporters. These ABC transporters…”
Get full text

PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR by Anreddy, Nagaraju, Patel, Atish, Sodani, Kamlesh, Kathawala, Rishil J, Chen, Eugenie P, Wurpel, John N D, Chen, Zhe-Sheng

“…Multidrug resistance protein 7 (MRP7, ABCC10) is a recently identified member of the ATP-binding cassette (ABC) transporter family, which adequately confers…”
Get full text

Nilotinib (AMN107, Tasigna ®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters by Tiwari, Amit K., Sodani, Kamlesh, Wang, Si-Rong, Kuang, Ye-Hong, Ashby, Charles R., Chen, Xiang, Chen, Zhe-Sheng

“…Nilotinib, a BCR-Abl tyrosine kinase inhibitor (TKI), was developed to surmount resistance or intolerance to imatinib in patients with Philadelphia positive…”
Get full text

Correction to “BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo” by Zhang, Dong-Mei, Shu, Chang, Chen, Jun-Jiang, Sodani, Kamlesh, Wang, Jiao, Bhatnagar, Jaya, Lan, Ping, Ruan, Zhi-Xiong, Xiao, Zhi-Jie, Ambudkar, Suresh V., Chen, Wei-Min, Chen, Zhe-Sheng, Ye, Wen-Cai

Get full text

Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo by Sodani, Kamlesh, Patel, Atish, Anreddy, Nagaraju, Singh, Satyakam, Yang, Dong-Hua, Kathawala, Rishil J., Kumar, Priyank, Talele, Tanaji T., Chen, Zhe-Sheng

“…[Display omitted] Multidrug resistance (MDR) is a phenomenon where cancer cells become simultaneously resistant to anticancer drugs with different structures…”
Get full text

Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport by Patel, Atish, Li, Tian-Wen, Anreddy, Nagaraju, Wang, De-Shen, Sodani, Kamlesh, Gadhia, Sanket, Kathawala, Rishil, Yang, Dong-Hua, Cheng, Changmei, Chen, Zhe-Sheng

“…[Display omitted] Cancer is a disease whose treatment is often limited due to the development of a phenomenon known as multidrug resistance (MDR). There is an…”
Get full text

PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells by Patel, Atish, Tiwari, Amit K., Chufan, Eduardo E., Sodani, Kamlesh, Anreddy, Nagaraju, Singh, Satyakam, Ambudkar, Suresh V., Stephani, Ralph, Chen, Zhe-Sheng

“…Purpose Specific tyrosine kinase inhibitors were recently reported to modulate the activity of ABC transporters, leading to an increase in the intracellular…”
Get full text

Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance by Kuang, Ye-Hong, Shen, Tong, Chen, Xiang, Sodani, Kamlesh, Hopper-Borge, Elizabeth, Tiwari, Amit K., Lee, Jeferson W.K.K., Fu, Li-Wu, Chen, Zhe-Sheng

“…In recent years, a number of TKIs (tyrosine kinase inhibitors) targeting epidermal growth factor receptor (EGFR) family have been synthesized and some have…”
Get full text

Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study by Kathawala, Rishil J, Sodani, Kamlesh, Chen, Kang, Patel, Atish, Abuznait, Alaa H, Anreddy, Nagaraju, Sun, Yue-Li, Kaddoumi, Amal, Ashby, Jr, Charles R, Chen, Zhe-Sheng

“…Paclitaxel displays clinical activity against a wide variety of solid tumors. However, resistance to paclitaxel significantly attenuates the response to…”
Get full text

β-elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter by GUO, HUI-QIN, ZHANG, GUAN-NAN, WANG, YI-JUN, ZHANG, YUN-KAI, SODANI, KAMLESH, TALELE, TANAJI T, ASHBY, CHARLES R, CHEN, ZHE-SHENG

“…In the present in vitro study, we examined the effect of the compound β-elemene on the response of KB-C2 cells overexpressing the ABCB1 transporter to specific…”
Get full text

Saracatinib (AZD0530) is a potent modulator of ABCB1‐mediated multidrug resistance in vitro and in vivo by Liu, Ke‐Jun, He, Jie‐Hua, Su, Xiao‐Dong, Sim, Hong‐May, Xie, Jing‐Dun, Chen, Xing‐Gui, Wang, Fang, Liang, Yong‐Ju, Singh, Satyakam, Sodani, Kamlesh, Talele, Tanaji T., Ambudkar, Suresh V., Chen, Zhe‐Sheng, Wu, Hai‐Ying, Fu, Li‐Wu

“…Saracatinib, a highly selective, dual Src/Abl kinase inhibitor, is currently in a Phase II clinical trial for the treatment of ovarian cancer. In our study, we…”
Get full text

BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo by Zhang, Dong-Mei, Shu, Chang, Chen, Jun-Jiang, Sodani, Kamlesh, Wang, Jiao, Bhatnagar, Jaya, Lan, Ping, Ruan, Zhi-Xiong, Xiao, Zhi-Jie, Ambudkar, Suresh V, Chen, Wei-Min, Chen, Zhe-Sheng, Ye, Wen-Cai

“…23-O-(1,4′-Bipiperidine-1-carbonyl)betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic acid (23-HBA), shows a reversal effect on multidrug…”
Get full text